CAS: 144735-57-9; 4-(5-(3-Hydroxypropyl)-7-Methoxybenzofuran-2-yl)-2-Methoxyphenol

该化合物是一种从苯并呋喃衍生的苯酚化合物,可能用于制药和生化研究,其结构特征,包括氢丙基和甲氧代基替代成分,有助于其独特的再活性和溶性特征.该化合物的苯并呋喃核心,加上苯丙胺功能,表明其在合成有机化学中作为中间体或作为生物活性分子开发的搭配体具有实用性.其双甲氧基混合物组会增强稳定性,而氢丙基化合物的侧链则可能提高与极溶剂的兼容性.该化合物对于涉及抗氧化性特性,酶抑制性或作为更复杂的循环系统的前体的研究具有兴趣.建议在惰性条件下进行适当处理和储存,以维护其完整性.

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上下游产品

furan5-((2-methoxycarbonyl)ethyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran 4-benzyloxy-3-methoxyacetophenone vanillin 5-bromo-4-hydroxy-3-methoxybenzaldehyde furan-4-carbaldehyde5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran-4-carbaldehyde furan5-(3-hydroxypropyl)-7-methoxy-3-methyl-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran 5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzo[b]furan-carbaldehyde 2-(4-hydroxy-3-methoxyphenyl)-5-(3-acetoxypropyl)-7-methoxybenzofuran bis(pinacol)diborane 5-bromo-2-(4-morpholinyl)pyridine 5-bromo-2-chloropyridine 6-(4-ethoxy-3-methoxy-phenyl)-2-methyl-3-(6-morpholin-4-yl-pyridin-3-yl)-imidazo[1,2-b]pyridazine 6-(4'-methoxy-biphenyl-4-yl)-2-methyl-3-(6-morpholin-4-yl-pyridin-3-yl)-imidazo[1,2-b]pyridazine 4-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-6-(6-morpholin-4-yl-pyridin-3-yl)-pyridazin-3-ylamine 4-(5-(4-((2R,5R)-2,5-bis(4-chloro-3-nitrophenyl)pyrrolidin-1-yl)phenyl)pyridin-2-yl)morpholine

合成工艺路线路线简述

    📜5-溴香兰素置于palladium On Activated Charcoal 四氢吡咯,吡啶,Ammonium Hydroxide,Lithium Aluminium Tetrahydride,盐酸羟胺,氢气,Copper(II) Sulfate体系中,用 四氢呋喃,吡啶 用作溶剂,化学反应 40.0H,反应生成2-(4-羟基-3-甲氧基苯基)-7-甲氧基-5-苯并呋喃丙醇
    参考文献:Compounds From Danshen. Part 7. Regioselective Introduction Of Carbon-3 Substituents To 5-Alkyl-7-Methoxy-2-Phenylbenzo[b]Furans: Synthesis Of A Novel Adenosine A1 Receptor Ligand And Its Derivatives
    标题:Compounds From Danshen. Part 7. Regioselective Introduction Of Carbon-3 Substituents To 5-Alkyl-7-Methoxy-2-Phenylbenzo[b]Furans: Synthesis Of A Novel Adenosine A1 Receptor Ligand And Its Derivatives
    摘要:By Maintaining The Balance Between The Electronic Requirements,The Stereochemical Restrictions As Well As The Kinetic And Thermodynamic Factors,The Unprecedented Regioselective Electrophilic Aromatic Substitution Of Formyl And Nitro Groups To Carbon-3 Of 5-Alkyl-7-Methoxy-2-Phenylbenzo[b]Furans Have Been Achieved. Subsequent Transformation Of The Resulting Formyl Group Into Methyl,Hydroxymethyl,1-Hydroxyethyl,And Cyano Groups Are Also Described.
    Doi:10.1021/jo00052A046

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    主要参考文献

    参考标题:An Alternate Method For The Synthesis Of 2-Aryl/alkyl-5-Bromo-7-Methoxy Benzofurans; Application To The Synthesis Of Egonol, Homoegonol, And Analogs Via Heck Reaction
    作者:Kishor R. More,R.S. Mali |发布日期:2016.11
    摘要:We Herein Report The General, Versatile, And Convenient Method For The Synthesis Of 2-Arly/alkyl-5-Bromo-7-Methoxy Benzofurans From Easily Available O-Vanillin In Five Steps. These Benzofurans Was Successfully Converted Into Biological Active Natural Products Egonol, Homoegonol, And Analogous On Applying Heck Reaction Using Ethyl/methyl Acrylate In The Presence Of Palladium Catalyst.

    合成参考文献


    参考文献:10.1016/j.cbi.2010.09.017
    摘要:Sung HY, Jun JG, Kang SW, Kim HS, Shin D, Kang IJ, Kang YH. Novel Danshen methoxybenzo[b]furan derivative antagonizing adipogenic differentiation and production of inflammatory adipokines. Chem Biol Interact. 2010 Dec 05;188(3):457–66. doi: 10.1016/j.cbi.2010.09.017.
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