CAS: 14173-39-8; 4-Chloro-L-Phenylalanine

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7424-00-2 14091-08-8 142994-19-2

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CAS号14091-10-2 2-ACETYLAMINO-3... | CAS号1615-02-7 4-氯肉桂酸 | CAS号127273-12-5 3-(4-chlorophen... | CAS号7424-00-2 DL-4-氯苯基丙氨酸 | CAS号4251-65-4 对氯苯乙醛 | CAS号104-83-6 4-氯氯苄 | CAS号1428149-31-8 4-chloro-(RS)-p... | CAS号14173-40-1 4-氯-DL-苯丙氨酸甲酯盐酸盐 | CAS号123052-81-3 (2S,5S)-tert-bu... | CAS号14091-10-2 2-ACETYLAMINO-3... | CAS号201864-00-8 2-Amino-3-(4-ch... | CAS号14173-40-1 4-氯-DL-苯丙氨酸甲酯盐酸盐 | CAS号3617-01-4 3-(4-氯苯基)-2-羟基-丙烯酸 | CAS号57213-16-8 3-氨基-L-苯丙氨酸

📜对氯肉桂酸置于氨基甲酸铵,Aromatic Ammonia-lyase From Loktanella Atrilutea体系中,用93 %的收率获得l-4-氯苯丙氨酸
参考文献:Loktanella Atrirudea 芳香氨裂解酶的生物催化潜力
标题:Loktanella Atrirudea 芳香氨裂解酶的生物催化潜力
摘要:来自loktanella Atrirudea ( La Aal) 的芳香氨裂解酶对 3,4-二甲氧基反式肉桂酸表现出高活性,而对天然 Aal 底物的活性却出人意料地降低.在最佳反应条件下,La Aal 表现出多种肉桂酸转化的多功能性.虽然la Aal 可能被归类为酪氨酸氨裂解酶(tal,Ec 4.3.1.23),但其强烈独特的属性表明其在非天然苯丙氨酸的转化中发挥着重要作用.
Doi:10.1002/cbic.202400011

专利信息

专利号:US-7230101-B1
优先权日:2002-08-28
标 题:Synthesis of methotrexate-containing heterodimeric molecules
发明人：MURTHI KRISHNA K; SMITH CHASE C
权利人:GPC BIOTECH INC
摘要:The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:

专利号:US-9938509-B2
优先权日:2010-12-08
标 题 :Biocatalysts and methods for the synthesis of armodafinil
发明人：ANG EE LUI; ALVIZO OSCAR; BEHROUZIAN BEHNAZ; CLAY MICHAEL D; COLLIER STEVEN J; EBERHARD ELLEN D; FAN FU; SONG SHIWEI; SMITH DEREK J; WIDEGREN MAGNUS; WILSON ROBERT; XU JUNYE; ZHU JUN
权利人:CODEXIS INC
摘要:The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.

专利号:US-5554753-A
优先权日:1993-08-25
标 题:Catalytic enantioselective synthesis of α-amino acid derivatives by phase-transfer catalysis
发明人：O'DONNELL MARTIN J; WU SHENGDE; ESIKOVA IRENA; MI AIQIAO
权利人:INDIANA UNIVERSITY FOUNDATION
摘要:Described are improved processes for the enantioselective synthesis of α-amino acids which involve combinations of solvents, highly-mixed and low-temperature reaction conditions, and novel catalysts. Also described are novel catalysts and precursors to α-amino acid derivatives.

专利号:US-7122628-B2
优先权日:2000-12-22
标 题:Process for the synthesis of a peptide having a Trp residue
发明人：JACKSON STEVEN ALLEN
权利人:IPSEN MFG IRELAND LTD
摘要:A process for the solid phase synthesis of a peptide having at least one thyptophan residue, wherein said method comprises temporarily protecting the indole ring of said tryptophan residue with a side chain protecting group which is labile to a base wherein said protecting group is removed during cleavage of said peptide from the solid support.

专利号:US-2023212788-A1
优先权日:2020-03-26
标 题:New method for automated on-demand biomolecular array synthesis
发明人：ZHANG YIXIN; LIN WEILIN
权利人:UNIV DRESDEN TECH
摘要:The invention provides an amphiphilic coating for the direct and rapid synthesis of an array of peptides and small molecular compounds on a planar surface of a solid support, comprising a hydrophilic chemical structure and a lipophilic group, wherein said peptides and small molecular compounds differ from spot to spot from each other in the chemical structure, characterized in that said amphiphilic coating possesses low wettability to polar aprotic solvents used in the array synthesis; said amphiphilic coating possessing low wettability is designed that it can be converted to a coating possessing high wettability by hydrolysis of the lipophilic group; and said amphiphilic coating comprises an amino group for the reaction with an electrophilic reagent. The invention further provides a solid support comprising said amphiphilic coating and a method for method for the direct and rapid synthesis of an array of peptides and small molecular compounds on a planar surface of a solid support, wherein said planar surface of a solid support comprises said amphiphilic coating. Said method includes the enhancing of the wettability of a glass surface to organic solvents to realize automated on-demand biomolecular array synthesis comprising both, peptides and small molecular compounds. The amphiphilic surface can be switched to a hydrophilic surface, resulting in high density arrays suitable for protein- and cell-based screening.

专利号:US-6117974-A
优先权日:1991-10-02
标题:Libraries of backbone-cyclized peptidomimetics
发明人：GILON CHAIM; HORNIK VERED
权利人:PEPTOR LTD; YISSUM RES DEV CO
摘要:Libraries of novel backbone-cyclized peptide analogs are formed by means of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building units used in the synthesis of these backbone-cyclized peptide analogs are N(((-functionalized) amino acids constructed to include a spacer and a terminal functional group. One or more of these N(((-functionalized) amino acids are incorporated into a library of peptide sequences, preferably during solid phase peptide synthesis. The reactive terminal functional groups are protected by specific protecting groups that can be selectively removed to effect either backbone-to-backbone or backbone-to-side chain cyclizations. The invention is exemplified by libraries of backbone-cyclized bradykinin analogs, somatostatin analogs, BPI analogs and Substance P analogs having biological activity. Further embodiments of the invention are Interleukin-6 receptor derived peptides having ring structures involving backbone cyclization.