专利号:US-4769445-A 优先权日:1985-03-04 标 题:Process for the solid phase synthesis of peptides which contain sulfated tyrosine 发明人:COMSTOCK JEANNE; ROSAMOND JAMES D 权利人:PENNWALT CORP 摘要:Peptides and Peptide amides such as cholecystokinin (CCK-8) are synthesized in improved yields and purity by a solid phase process. The requisite protected peptide is elaborated and sulfated on a solid support, deprotected, and cleaved from the solid support to give the total synthesis of CCK-8 on a solid support. Thereafter, the peptide is purified in a single step by ion exchange chromatography to provide analytically pure CCK-8.
专利号:US-6217901-B1 优先权日:1999-05-25 标题:Liposome-assisted synthesis of polymeric nanoparticles 发明人:PERROTT MICHAEL G; BARRY STEPHEN E 权利人:ALNIS LLC 摘要:Synthetic polymer complements (SPCs) are provided, as well as methods for their synthesis and use. The SPCs range in size from about 20 to about 1000 nm. The SPCs have surfaces that are complementary to surface sites of target molecules, resulting in the ability of the SPCs to selectively bind to molecular targets. The molecular recognition capability of these particles enables their use in diagnostic, therapeutic, and separation applications. The SPC is formed by contacting a target template molecule with a set of building blocks solubilized in the interior of a liposome, which building blocks are then polymerized into a network to form the synthetic polymer complement in the interior of the liposome. The target templates are removed to produce complementary sites in a SPC that map the surface of the target, resulting in a water-soluble SPC nanoparticle of similar dimensions as the interior of the liposome that originally supported it and capable of molecular recognition.
专利号:US-10040964-B2 优先权日:2014-02-12 标题:Use of tristyrylphenol alkoxylate sulfosuccinates in emulsion polymerization and coatings 发明人:LUEBKE GARY; RESCHAK KEITH; LUKA RENEE; KALTENBACH JARROD 权利人:STEPAN CO 摘要:Disclosed are the use of novel surfactants for the synthesis of emulsion polymer latexes, particularly those used in paints, coatings, and pressure sensitive adhesives. The surfactant compositions for emulsion polymer latexes comprise sterically bulky surfactants whose composition comprises at least one alkoxylated polyaryl substituted aromatic sulfosuccinate compound. The novel surfactants provide for the production of stable, small particle size distribution emulsion polymer latexes. The resulting latexes, when formulated into latex paint, impart improvements in water resistance as measured by film opacity, blister resistance and improved leveling characteristics, and when formulated into pressure sensitive adhesives, provide improved water resistance characteristics as measured by film opacity.
专利号:US-7846656-B2 优先权日:2001-10-16 标 题:Composition for polymerizing immobilization of biological molecules and method for producing said composition 发明人:MIRZABEKOV ANDREI DARIEVICH; RUBINA ALLA JURIEVNA; PANKOV SERGEI VASILIEVICH 权利人:INST MOLEKULYARNOI BIOLOG IM V 摘要:The invention refers to the field of molecular biology and bio-organic chemistry and deals with a composition for immobilization in polymer carriers of oligonucleotides, proteins, nucleic acids or any other molecules, which structure comprises active groups, including amino- or sulfhydryl groups, as well as a method for immobilization of various molecules including oligonucleotides, proteins, nucleic acids or any other molecules which structure comprises active groups, including amino- or sulfhydryl groups, consisting of a porous polymer being obtained on the basis of the composition claimed under conditions of addition or substitution reaction (radical, nucleophilic, or electrophilic nature, etc.) during synthesis of polymer by photo- and chemical initiated polymerization. n The composition claimed, as well as the method of immobilization of molecules in a polymer carrier using these compositions, may be used in various applications including microchips manufacturing that use is made of molecular biology on DNA sequencing and mapping, on detection of mutations and a whole range of medical applications.
专利号:US-9534062-B2 优先权日:2014-07-02 标 题:Synthesis of an acrylate polymer in flow reactor 发明人:HE MINGQIAN; HORN CLEMENS RUDOLF; HU JIEYU; JEAN PATRICK; NIU WEIJUN; SCHISSEL DAVID NEAL; WINNINGHAM MICHAEL JAMES 权利人:CORNING INC 摘要:An improved process for synthesizing acrylic polymers, which is highly controllable to achieve high molecular weight, high conversion rate, and low polydispersity involves continuously introducing initiator(s), acrylic monomer(s), and optionally other monomers capable of polymerizing with the acrylic monomer(s), into a microchannel of a microreactor having an integral micromixer and an integral heat exchanger.
专利号:WO-2022038386-A1 优先权日:2020-08-21 标 题:Polyacrilamide type solid-supported nucleic acid synthesis 发明人:OST TOBIAS WILLIAM BARR; MCINROY GORDON ROSS; GABER ZACHARY BEYER; SWERDLOW HAROLD; TOGNOLONI CECILIA 权利人:NUCLERA NUCLEICS LTD 摘要:The invention relates to improved methods of enzymatic solid-supported nucleic acid synthesis that make use of terminal deoxynucleotidyl transferase (TdT) enzymes or modified terminal deoxynucleotidyl transferase (TdT) enzymes on polyacrylamide type supports. The invention further relates to the use of kits comprising said enzymes in a method of solid-supported nucleic acid synthesis.
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合成参考文献
摘要:Compound: Tris(hydroxymethyl)acrylamidomethane homopolymer 摘要:Manyem, S.; Sibi, M. P., Science of Synthesis, (2005) 21, 585.