CAS: 1255529-24-8; N1-(5-Chloropyridin-2-yl)-N2-((1R,2R,4R)-4-(Dimethylcarbamoyl)-2-(5-Methyl-4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridine-2-Carboxamido)Cyclohexyl)Oxalamide
该化合物是一个复杂的有机化合物,其特征是多功能结构,包括乙二酰基和有助于其生物活动的各种替代物. 氯基和环的存在表明有可能与生物目标发生相互作用,从而使生物目标对医药化学感兴趣.二甲基氨基和基动物在提高溶性与生物活性方面可能发挥作用.该化合物可能会表现出特定的药性特性,有可能在生物化学途径中起到抑制或调节作用.其结构复杂性意味着它可能受制于多种代谢过程,影响其功效和安全特征.与许多化合物一样,在这种性质下,它具有关键性,包括治疗性,稳定性,再性环境.
- 英文名称N1-(5-Chloropyridin-2-yl)-N2-((1R,2R,4R)-4-(Dimethylcarbamoyl)-2-(5-Methyl-4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridine-2-Carboxamido)Cyclohexyl)Oxalamide
- 中文名称依度沙班杂质RRR
- IUPAC名称N1-(5-chloropyridin-2-yl)-N2-((1R,2R,4R)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide
- 其它别名Ethanediamide, N1-(5-Chloro-2-Pyridinyl)-N2-[(1R,2R,4R)-4-[(Dimethylamino)Carbonyl]-2-[[(4,5,6,7-Tetrahydro-5-Methylthiazolo[5,4-C]Pyridin-2-yl)Carbonyl]Amino]Cyclohexyl]-; N1-(5-Chloropyridin-2-yl)-N2-((1R,2R,4R)-4-(Dimethylcarbamoyl)-2-(5-Methyl-4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridine-2-Carboxamido)Cyclohexyl)Oxalamide; N-(5-Chloro-2-Pyridyl)-N'-[(1R,2R,4R)-4-(Dimethylcarbamoyl)-2-[(5-Methyl-6,7-Dihydro-4H-Thiazo; Edoxaban (Rrr)-Isomer; Edoxaban Impurity 25; N-(5-Chloro-2-Pyridyl)-N'-[(1R,2R,4R)-4-(Dimethylcarbamoyl)-2-[(5-Methyl-6,7-Dihydro-4H-Thiazolo[5,4-C]Pyridine-2-Carbonyl)Amino]Cyclohexyl]Oxamide; Edoxaban Isomer (Rrr); Enantiomer(Rrr)
- CAS编号1255529-24-8
- MFCD编号:MFCD27987166
- 分子式:C24H30ClN7O4S分子量:548.07
- 产品CID: 379530
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2912110000-甲醛
2912120000-乙醛
2921211000-乙二胺
2924191000-二甲基甲酰胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
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主要参考文献
1: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Available from http://www.ncbi.nlm.nih.gov/books/NBK548805/ doi: 10.1080/14779072.2019.1598263. Epub 2019 Mar 27. Review. Available from http://www.ncbi.nlm.nih.gov/books/NBK535088/ No abstract available. Available from http://www.ncbi.nlm.nih.gov/books/NBK534995/ Available from http://www.ncbi.nlm.nih.gov/books/NBK535077/ Available from http://www.ncbi.nlm.nih.gov/books/NBK500740/ doi: 10.1136/bmjebm-2018-111007. Epub 2018 Jun 29. Review. Available from http://www.ncbi.nlm.nih.gov/books/NBK475920/ Available from http://www.ncbi.nlm.nih.gov/books/NBK458399/ doi: 10.1080/14740338.2017.1372418. Epub 2017 Sep 18. Review. doi: 10.1080/17425255.2017.1338274. Epub 2017 Jun 13. Review. doi: 10.1016/j.amjmed.2017.02.048. Epub 2017 Apr 6. Review. Review. French. doi: 10.1007/s10354-017-0548-4. Epub 2017 Feb 24. Review. German. doi: 10.4317/jced.53431. eCollection 2017 Feb. Review.
16: De Caterina R, Ageno W, Boriani G, Colonna P, Ghirarduzzi A, Patti G, Rossini R, Rubboli A, Schinco P, Agnelli G. Edoxaban in Atrial Fibrillation and Venous Thromboembolism-Ten Key Questions and Answers: A Practical Guide. Adv Ther. 2017 Mar;34(3):620-637. doi: 10.1007/s12325-017-0488-9. Epub 2017 Feb 13. Review.
17: Poulakos M, Walker JN, Baig U, David T. Edoxaban: A direct oral anticoagulant. Am J Health Syst Pharm. 2017 Feb 1;74(3):117-129. doi: 10.2146/ajhp150821. Review. Epub 2016 Nov 18. Review. doi: 10.1080/17512433.2016.1258301. Epub 2016 Nov 17. Review. Erratum in: Expert Rev Clin Pharmacol. 2017 Jan;10 (1):1. doi: 10.1177/1074248416675732. Epub 2016 Nov 2. Review.
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