CAS: 1166227-08-2; (S)-N1-(2-(Tert-Butyl)-4'-Methyl-[4,5'-Bithiazol]-2'-yl)Pyrrolidine-1,2-Dicarboxamide

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imidazole-1-carboxylic acid (2-tert-butyl-4'-methyl-[4,5']bithiazolyl-2'-yl)-amide L-prolinamide 5-acetyl-2-(N-acetylamino)-4-methylthiazole 1,1'-carbonyldiimidazole

N-(5-Acetyl-4-Methylthiazol-2-yl)Acetamide置于盐酸,溴体系中,用 1,4-二氧六环,乙醇 用作溶剂,化学反应 93.0H,反应生成A 66; (2S)-N1-(2-叔丁基-4'-甲基[4,5'-联噻唑]-2'-基)-1,2-吡咯烷二甲酰胺
参考文献:Identification And Optimisation Of A 4',5-Bisthiazole Series Of Selective Phosphatidylinositol-3 Kinase Alpha Inhibitors
标题:Identification And Optimisation Of A 4',5-Bisthiazole Series Of Selective Phosphatidylinositol-3 Kinase Alpha Inhibitors
摘要:Exploring The Affinity-Pocket Binding Moiety Of A 2-Aminothiazole (S)-Proline-Amide-Urea Series Of Selective Pi3K Alpha Inhibitors Using A Parallel-Synthesis Approach Led To The Identification Of A Novel 4',5-Bisthiazole Sub-Series. The Synthesis And Optimisation Of Both The Affinity Pocket And (S)-Proline Amide Moieties Within This 4',5-Bisthiazole Sub-Series Are Described. From This Work A Number Of Analogues,Including 14 (A66) And 24,Were Identified As Potent And Selective Pi3K Alpha Inhibitor In Vitro Tool Compounds. (C) 2015 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2015.06.078