CAS: 98-92-0; 3-(Aminocarbonyl)Pyridine

• 英文名称3-(Aminocarbonyl)Pyridine
• 中文名称烟酰胺
• IUPAC名称nicotinamide
• 其它别名3-Pyridinecarboxamide; Niacinamide
• CAS编号98-92-0
• MFCD编号:MFCD00006395
• EINECS号:202-713-4
• 分子式:C6H6N2O
• 分子量:122.12
• 产品CID: 2028348
• 产品分类原料药 → 维生素类与矿物质类药 → 维生素B类药

• 相似结构搜索
• 产品信息参考;;;;
• InChIKey: DFPAKSUCGFBDDF-UHFFFAOYSA-N
• InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)…
• 计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数1.0

物理性质

• 熔点128-131 °C(文献)
• 沸点150-160 °C
• 闪点182 °C
• 密度360kg/m3
• PH:6.0-7.5 (50g/l, H2O, 20°C)
• pKa:3.3(at 20°C)
• PSA:55.98
• LogP:-0.38 at 21°C
• 折射率1.4660 (估算)
• 蒸汽压0Pa at 25°C
• 溶解性691G/l
• 敏感性An amine and amide. Acts as a weak base in solution. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
• 外观形态白色粉末
• 储存条件2-8°C
• 产品应用烟酰胺和烟酸在大多数声合下通用,烟酸在动物体内也生成烟酰胺.体内缺乏烟酸和烟酰胺时,会得糙皮病.因此它们可预防糙皮病.它们在蛋白质和糖的新陈代谢中起作用,可改善人类和动物的营养.除用作医药外,还大量用作食品和饲料添加剂.全世界的生产能力已超过3万吨.在日本,烟酰胺用于医药占40,饲料添加剂占50.食品添加剂占10.烟酸和烟酰胺无毒,在自然介多含于动物肝脏,肾脏,酵母和米糖中,烟酰胺对大鼠皮下注射LD50为1.7克/公斤.指标名称指标含量≥99熔点128.0-131.0°CPH值5.5-7.5(10水
• 性质描述白色针状结晶或粉末.熔点129-131°C.该品1克溶于1毫升水,1.5毫升醇及10毫升甘油,不溶于醚.味苦.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别严重眼刺激 类别2
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  皮肤致敏 类别1
  急性毒性 类别4(经口)
  严重眼刺激 类别2A
  严重眼刺激 类别2B
• 警示词Warning(警告)
• 危险描述H319 |造成严重眼刺激.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H317 |可能引起皮肤过敏反应.
  H336 |可能引起嗜睡或头晕.
  H302 |吞咽有害.
• 防范说明P264-P280-P305+P351+P338-P337+P313
• UN编号UN1230 - class 3 - PG 2 - Methanol, solution
• 危险品标志Xi,T,F
• 安全声明26-36-37/39-45-36/37-16-7
• 危险类别码36/37/38-39/23/24/25-23/24/25-11
• WGK Germany1

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 Nicotinamide 主要起始原料 2-Chloro-N,N-Dimethyl-3-Pyridinecarboxamide
• 53-57-6 = 98-92-0 + 1273577-05-1 + 1252804-06-0 + 53-84-9 + 20762-30-5
  反应条件:1.1S:H2O,16 H,50°C2.1S:H2O,16 H,50°C
  标题:Factors Influencing The Operational Stability Of Nadph-Dependent Alcohol Dehydrogenase And An Nadh-Dependent Variant Thereof In Gas/solid Reactors
  作者:By Kulishova,Liliya Et Al
  参考文献:Journal Of Molecular Catalysis B: Enzymatic 日期:2010 卷标:67(3-4) 页码:271-283]
  
  53-57-6 = 98-92-0 + 53595-18-9 + 3805-37-6 + 58-68-4 + 4457-01-6
  反应条件:1.1S:H2O,16 H,50°C
  标题:Factors Influencing The Operational Stability Of Nadph-Dependent Alcohol Dehydrogenase And An Nadh-Dependent Variant Thereof In Gas/solid Reactors
  作者:By Kulishova,Liliya Et Al
  参考文献:Journal Of Molecular Catalysis B: Enzymatic 日期:2010 卷标:67(3-4) 页码:271-283]
  
  53-57-6 = 98-92-0 + 53595-18-9 + 53-59-8 + 1273577-02-8 + 60-92-4 + 3805-37-6 + 58-68-4 + 4457-01-6 + 130-49-4
  反应条件:1.116 H,95°C
  标题:Factors Influencing The Operational Stability Of Nadph-Dependent Alcohol Dehydrogenase And An Nadh-Dependent Variant Thereof In Gas/solid Reactors
  作者:By Kulishova,Liliya Et Al
  参考文献:Journal Of Molecular Catalysis B: Enzymatic 日期:2010 卷标:67(3-4) 页码:271-283

海关参考信息

• 2912110000-甲醛
  2933310010-吡啶
  2939800000-其他生物碱
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管