CAS: 9007-49-2; 5-Amino-2-(((((5-Amino-2-(Hydroxymethyl)Tetrahydrofuran-3-yl)Oxy)(Hydroxy)Phosphoryl)Oxy)Methyl)Tetrahydrofuran-3-Yl ((5-Amino-3-Hydroxytetrahydrofuran-2-yl)Methyl) Hydrogen Phosphate

该化合物是一种生物聚合物,在大多数活生物体中是一种遗传物质;它由两根长的线条组成,形成双螺旋,每条线由核素组成;每一核素由磷酸组组成,一种脱氧核糖,四个氮基基组成之一:腺素,甲胺,细胞素或甘纳;这些基底的顺序是基因信息,对生物体的发育,功能和繁殖至关重要;DNA的特点是具有复制能力,能够将遗传信息从一代传到下一代;它还参与通过转录和翻译过程合成蛋白质;双螺旋结构的稳定性可归因于补充基底对子和基底体间防水的相互作用之间的氢联结;DNA通常见于尿细胞的核心和人造细胞的细胞表层,在生物技术和遗传工程应用中发挥着至关重要的作用.

结构式图片

合成工艺路线路线简述

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    专利信息


    专利号:US-2019031650-A1
    优先权日:2016-01-29
    标 题 :Dna alkylation and cross-linking agents as compounds and payloads for targeted therapies
    发明人:HERZON SETH; HEALY ALAN; CRAWFORD JASON; VIZCAINO MARIA; NIKOLAYEVSKIY HERMAN
    权利人:UNIV YALE
    摘要:The present invention is directed to compounds related to precolibactin pharmaceutical compositions based upon these compounds and methods of synthesis which are employed to provide intermediates and final compounds, which are principally alkylating agents and anticancer compounds. The chemical synthetic approach disclosed facilitates the synthesis of numerous precolibactin analogs which can be used in the treatment of cancer.

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    ✅ COA系统入驻 | 共享模式

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    摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118
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