CAS: 7623-13-4; 2,3-Dichloropropionylchloride

该化合物是有机化合物,其特征为乙基氯功能组,对高反应性,特别是水,形成盐酸和水解时相应的碳酸;该化合物具有两个与三碳丙基丙基碳链第二和第三碳原子相连的氯原子,有助于其再活动及有机合成中的潜在应用;它通常用作制作各种化学中间体,包括制药和农用化学物的碳化剂;由于它具有反应性,2,3-二氯丙基氯化物应谨慎处理,因为它可严重刺激皮肤,眼睛和呼吸系统;在与该化合物合作时,适当的安全防范措施,包括使用个人防护设备,并在通风良好区域或烟雾罩中工作,至关重要.

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CAS号79-00-5 1,1,2-三氯乙烷 | CAS号565-64-0 2,3-二氯丙酸 | CAS号2567-14-8 1,1,3-三氯丙烯 | CAS号2233-00-3 三氯丙烯-1 | CAS号107-94-8 3-氯丙酸 | CAS号473-81-4 DL-甘油酸 | CAS号110-88-3 三聚甲醛 | CAS号7446-70-0 氯化铝 | CAS号79-01-6 三氯乙烯 | CAS号50-00-0 甲醛 | CAS号565-64-0 2,3-二氯丙酸 | CAS号19433-84-2 2,3-二氯丙酰胺 | CAS号21369-76-6 α-Chloroacrylic... | CAS号3674-09-7 2,3-二氯乙酰丙酸甲酯 | CAS号7078-85-5 2,3-dichloro-N-... | CAS号6628-21-3 2,3-二氯丙酸乙酯 | CAS号50277-65-1 丙炔酰氯

合成工艺路线路线简述

  • 合成目标产物 2,3-Dichloropropionyl Chloride 主要起始原料 2,3-Dichloropropionic Acid
  • (文献来源)合成步骤主要原料 2,3-Dichloropropionic Acid
📜3-氯丙酸 反应生成 2,3-二氯丙酰氯
参考文献:Efficient .Alpha.-Halogenation Of Acyl Chlorides By N-Bromosuccinimide,N-Chlorosuccinimide,And Molecular Iodine
标题:Efficient .Alpha.-Halogenation Of Acyl Chlorides By N-Bromosuccinimide,N-Chlorosuccinimide,And Molecular Iodine
摘要:
DOI:10.1021/jo00911A026

海关参考信息

专利信息


专利号:US-6531477-B1
优先权日:1998-10-13
标 题:6-substituted pyrazolo [3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors
发明人:MARKWALDER JAY A; SEITZ STEVEN P; SHERK SUSAN R
权利人:DU PONT PHARM CO
摘要:The present invention relates to the synthesis of a novel class of pyrazolo[3,4-d]pyrimidin-4-ones of formula (I), alternatively represented by the tautomer (II):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cyclin dependent kinase 1-8 and their regulatory subunits know as cyclins A-H, K, N, and T.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-6559152-B2
优先权日:1998-10-13
标 题 :6-substituted pyrazolo[3,4-d]pyrimidin-4-ones useful as cyclin dependent kinase inhibitors
发明人:MARKWALDER JAY A; SEITZ STEVEN P; SHERK SUSAN R
权利人:DU PONT PHARM CO
摘要:The present invention relates to the synthesis of a novel class of pyrazolo[3,4-d]pyrimidin-4-ones of formula (I), alternatively represented by the tautomer (II):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cyclin dependent kinase 1-8 and their regulatory subunits know as cyclins A-H, K, N, and T.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-4066690-A
优先权日:1973-11-19
标题 :Process for the preparing α-chloroacrylic acid chlorides
发明人:REUSCHLING DIETER-BERND; JENSEN HARALD
权利人:HOECHST AG
摘要:α-Chloroacrylic acid chloride is obtained in a high yield by splitting off HCl from α,β-dichloropropionic acid chloride at an increased temperature and under reduced pressure in the presence of a tertiary phosphine, a quaternary phosphonium salt or a tertiary phosphine oxide, sulfide, halide or imine. α-Chloroacrylic acid chloride is important as a starting and intermediate material for further syntheses, especially as the starting material for the total synthesis of prostaglandins according to Corey.

专利号:US-3940439-A
优先权日:1973-11-14
标 题:Acid chloride synthesis
发明人:HARROW TERENCE ALFRED
权利人:SEARLE & CO
摘要:α,β-Unsaturated carboxylic acid chlorides are advantageously produced in high yields and with minimal formation of by-products by reaction of the corresponding carboxylic acid with oxalyl chloride.

专利号:CN-117881673-A
优先权日:2021-08-11
标 题 :Synthesis of bilirubin

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📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


参考文献:10.1007/bf00844092
摘要:Vasil'eva TT, Kost VN. Action of diethylamine on polychlorofluoropropenes of structure CH2=CXFn C13-n. Russian Chemical Bulletin. 1963 Sep;12(9):1449–52. doi: 10.1007/bf00844092.
参考文献:10.1007/bf00530306
参考文献:10.1023/b:cohc.0000046689.59548.e0
摘要:Martirosyan AO, Hovhanesyan VE, Gasparyan SP, Karapetyan AA, Panosyan GA, Martirosyan VO. Synthesis of Ethyl cis- and trans-4-Chloro-5-oxo-1,2-diphenylpyrrolidine-2-carboxylate. Chemistry of Heterocyclic Compounds. 2004 Aug;40(8):1007–8. doi: 10.1023/b:cohc.0000046689.59548.e0.
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