专利号:US-6531477-B1 优先权日:1998-10-13 标 题:6-substituted pyrazolo [3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors 发明人:MARKWALDER JAY A; SEITZ STEVEN P; SHERK SUSAN R 权利人:DU PONT PHARM CO 摘要:The present invention relates to the synthesis of a novel class of pyrazolo[3,4-d]pyrimidin-4-ones of formula (I), alternatively represented by the tautomer (II):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cyclin dependent kinase 1-8 and their regulatory subunits know as cyclins A-H, K, N, and T.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
专利号:US-6559152-B2 优先权日:1998-10-13 标 题 :6-substituted pyrazolo[3,4-d]pyrimidin-4-ones useful as cyclin dependent kinase inhibitors 发明人:MARKWALDER JAY A; SEITZ STEVEN P; SHERK SUSAN R 权利人:DU PONT PHARM CO 摘要:The present invention relates to the synthesis of a novel class of pyrazolo[3,4-d]pyrimidin-4-ones of formula (I), alternatively represented by the tautomer (II):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cyclin dependent kinase 1-8 and their regulatory subunits know as cyclins A-H, K, N, and T.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
专利号:US-4066690-A 优先权日:1973-11-19 标题 :Process for the preparing α-chloroacrylic acid chlorides 发明人:REUSCHLING DIETER-BERND; JENSEN HARALD 权利人:HOECHST AG 摘要:α-Chloroacrylic acid chloride is obtained in a high yield by splitting off HCl from α,β-dichloropropionic acid chloride at an increased temperature and under reduced pressure in the presence of a tertiary phosphine, a quaternary phosphonium salt or a tertiary phosphine oxide, sulfide, halide or imine. α-Chloroacrylic acid chloride is important as a starting and intermediate material for further syntheses, especially as the starting material for the total synthesis of prostaglandins according to Corey.
专利号:US-3940439-A 优先权日:1973-11-14 标 题:Acid chloride synthesis 发明人:HARROW TERENCE ALFRED 权利人:SEARLE & CO 摘要:α,β-Unsaturated carboxylic acid chlorides are advantageously produced in high yields and with minimal formation of by-products by reaction of the corresponding carboxylic acid with oxalyl chloride.
专利号:CN-117881673-A 优先权日:2021-08-11 标 题 :Synthesis of bilirubin