CAS: 699-02-5; 2-(P-Tolyl)Ethanol

该化合物是一种多用途芳香醇,其分子式为C9H12O,其特征是附于一个合成甲基代苯环的氢氧化甲基组,该化合物通常用作有机合成的中间体,特别是在香料,药品和特殊化学品的生产中,其结构在氢氧和芳香位置上都具有回活动性,使适应性应用能够发挥功能.该亚甲基组在保持回活动的同时增强稳定性,使其成为精细化学合成的有益构件.可提供高纯度以满足严格的工业要求,确保合成工艺的性能一致.建议进行适当的处理和储存,因为对氧化敏感.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

oxirane 4-methylphenylmagnesium iodide toluene para-methylphenylmagnesium bromide chloromethyl-(4-methyl-phenethyl)-ether 3,4-dihydro-7-methyl-1H-is°Chromene 1-ethenyl-4-methylbenzene 2-(4-methylphenyl)ethyl bromide

合成工艺路线路线简述

    对苯二甲醇置于dicobalt octacarbonyl,一氧化碳,氢气体系中,化学反应生成 2-(4-甲基苯基)乙醇
    参考文献:Chemistry Of The Oxo And Related Reactions. Vi. Experiments With Meta-And Para-Substituted Benzyl Alcohols
    标题:Chemistry Of The Oxo And Related Reactions. Vi. Experiments With Meta-And Para-Substituted Benzyl Alcohols
    摘要:
    DOI:10.1021/ja01136A032

    海关参考信息

    专利信息


    专利号:US-4381400-A
    优先权日:1981-02-27
    标 题 :Process for the synthesis of isosorbide mononitrates
    发明人:EMEURY JEAN-MARIE; WIMMER ERIC
    权利人:POUDRES & EXPLOSIFS STE NALE
    摘要:The invention relates to the synthesis of isosorbide mononitrates. n The process according to the invention consists in reacting a hydrazine derivative with isosorbide dinitrate, in a polar solvent medium. The reaction is preferably carried out at the reflux temperature of the solvent medium, with an excess of the hydrazine derivative. A preferred solvent medium is a mixture of tetrahydrofuran and methanol. The process leads to the preferential formation of isosorbitol-2-mononitrate, which is a coronary vasodilator.

    专利号:US-8647823-B2
    优先权日:2005-07-22
    标 题 :Polynucleotide synthesis on a modified surface
    发明人:PARK JOON-WON; HONG BONG-JIN
    权利人:PARK JOON-WON; HONG BONG-JIN; POSTECH FOUNDATION; POSCO
    摘要:The present invention relates to a method for the synthesis of a polynucleotide on a modified surface of a substrate, wherein the modified surface is obtained by chemically modifying with macromolecules in which a plurality of termini of the branched region are bound to the surface and a terminus of the linear region is functionalized.

    专利号:US-6194612-B1
    优先权日:1995-10-17
    标 题:Template for solution phase synthesis of combination libraries
    发明人:BOGER DALE L; CHENG SOAN; MYERS PETER L
    权利人:SCRIPPS RESEARCH INST; COMBICHEM INC
    摘要:This invention features a template for synthesizing combinatorial libraries, methods of synthesizing combiatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this invention.

    专利号:US-4217452-A
    优先权日:1974-02-09
    标 题:Synthesis for the preparation of tetracyclic compounds
    发明人:OLIVIE JACQUES
    权利人:AKZONA INC
    摘要:The invention relates to a new synthesis for the preparation of tetracyclic compounds of the general formula: ##STR1## as well as the pharmaceutically acceptable salts thereof, in which: n is the number 1 or 2, n m is the number 1, if n=2 and the number 2, if n=1, n R 1 and R 2 stand for hydrogen, hydroxy, halogen, lower alkyl (1-4 C), lower alkoxy (1-4 C) or trifluoromethyl and n R 3 represents hydrogen, alkyl (1-6 C), aralkyl (7-10 C) or an amino alkyl group (1-6 C), in which the nitrogen atom has been substituted by two alkyl groups (1-4 C), or the nitrogen atom forms part of a heterocyclic 5- or 6-membered ring, n having valuable biological properties.

    专利号:US-2009018325-A1
    优先权日:2006-03-15
    标 题:Process for preparing l-nucleic acid derivatives and intermediates thereof
    发明人:CERCUS JACQUES; FOULKES MICHAEL; HEINZ THOMAS; NIEDERER DANIEL; SCHMITZ BEAT
    权利人:CERCUS JACQUES; FOULKES MICHAEL; HEINZ THOMAS; NIEDERER DANIEL; SCHMITZ BEAT
    摘要:A novel method has been found to produce 2,2′-anhydro-1-(β-L-arabinofuranosyl)thymine as a novel useful intermediate compound. A novel method has been further found to produce thymidine from 2,2′-anhydro-1-(β-L-arabinofuranosyl)thymine. According to these methods, synthesis of various L-nucleic acid derivatives, synthesis of which has been difficult till now, is possible.

    专利号:US-4254031-A
    优先权日:1974-02-09
    标 题:Synthesis for the preparation of tetracyclic compounds
    发明人:OLIVIE JACQUES
    权利人:AKZONA INC
    摘要:The invention relates to a new synthesis for the preparation of tetracyclic compounds of the general formula ##STR1## as well as the pharmaceutically acceptable salts thereof, in which: n is the number 1 or 2, n m is the number 1, if n=2 and the number 2, if n=1, n R 1 and R 2 stand for hydrogen, hydroxy, halogen, lower alkyl (1-4 C), lower alkoxy (1-4 C) or trifluoromethyl and n R 3 represents hydrogen, alkyl (1-6 C), aralkyl (7-10 C) or an amino alkyl group (1-6 C), in which the nitrogen atom has been substituted by two alkyl groups (1-4 C), or the nitrogen atom forms part of a heterocyclic 5- or 6-membered ring, n having valuable biological properties.
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    主要参考文献

    [参考文献]: Kuo-Ching Wen, Et Al. Tyrosol And Its Analogues Inhibit Alpha-Melanocyte-Stimulating Hormone Induced Melanogenesis. Int J Mol Sci. 2013 Nov 28;14(12):23420-40.

    合成参考文献


    摘要:Molander, G. A.; Ryu, D., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 2, 45.
    摘要:Ilari, A.; Bonamore, A.; Boffi, A., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 166.
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