CAS: 5411-22-3; Benzphetamine Hydrochloride

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CAS号156-08-1 苄非他明 | CAS号100-44-7 氯化苄 | CAS号51-57-0 盐酸脱氧麻黄碱 | CAS号537-46-2 晶体,晶粒,结晶 | CAS号345-78-8 盐酸伪麻黄碱

📜在 盐酸,Potassium Carbonate体系中,用 水,乙酸乙酯 作为反应溶剂,化学反应 40.5H,反应生成 盐酸苄非他明
参考文献:An Efficient,Scalable Process For Benzphetamine Hydrochloride
标题:An Efficient,Scalable Process For Benzphetamine Hydrochloride
摘要:Commercial Manufacturing Of Benzphetamine Hydrochloride Along With Its Impurity Profiling Is Disclosed. Deoxygenation Of Pseudoephedrine Is Reported With Similar To 100% Retention By Shielding The Amine Group As Its Tert-Butyl Carbamate,Which Is Very Straightforward To Eliminate At The End. Four Unknown Process-Related Impurities Are Isolated From The Samples Of Final Api And Characterized On The Basis Of Their NMR And Mass Spectral Analysis. Structures Of The Isolated Impurities Are Confirmed By Independent Syntheses And Coinjecting With The Isolated One.
DOI:10.1021/op400313Y

专利信息

专利号:US-2011040105-A1
优先权日:2008-04-16
标题 :Processes useful for the synthesis of (r)-1--2-methyl-pyrrolidine
发明人：HUBER CHRISTIAN H; KHULMAN YOUNG MI; TANDEL SAGUN K; JOHANNSEN STEPHEN R; WANG TINGMIN; ANGELL PAUL
权利人:ARENA PHARM INC
摘要:Processes useful for making a pharmaceutically useful compound according to Formula (I), forms of such a compound, and intermediates useful in such processes are described.

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:CN-102066319-A
优先权日:2008-04-16
标 题 :Processes useful for the synthesis of (R)-1-{2-[4'-(3-methoxypropane-1-sulfonyl)-biphenyl-4-yl]-ethyl}-2-methyl-pyrrolidine

专利号:EP-2282992-A1
优先权日:2008-04-16
标 题 :Processes useful for the synthesis of (r)-1-{2-ý4'-(3-methoxypropane-1-sulfonyl)-biphenyl-4-yl¨-ethyl}-2-methyl-pyrrolidine

专利号:WO-2009128907-A1
优先权日:2008-04-16
标 题 :Processes useful for the synthesis of (r)-1-{2-[4'-(3-methoxypropane-1-sulfonyl)-biphenyl-4-yl]-ethyl}-2-methyl-pyrrolidine

专利号:US-9550795-B2
优先权日:2011-08-31
标 题:Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
发明人：BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; HELAL CHRISTOPHER JOHN; O'NEILL BRIAN THOMAS
权利人:BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; HELAL CHRISTOPHER JOHN; O'NEILL BRIAN THOMAS; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I, n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.