CAS: 43229-01-2; 1-(4-(Benzyloxy)-3-Nitrophenyl)-2-Bromoethanone

上下游产品

CAS号14347-05-8 4-苄氧基-3-硝基苯乙酮 | CAS号6322-56-1 4'-羟基-3'-硝基苯乙酮 | CAS号99-93-4 对羟基苯乙酮 | CAS号100-44-7 氯化苄 | CAS号100-39-0 溴化苄 | CAS号51582-41-3 1-(4-苄氧基-3-硝基)苯基环氧乙烷 | CAS号188730-94-1 (R)-2-(4-(苄氧基)-... | CAS号201677-59-0 (R)-N-(2-(苄氧基)-... | CAS号193761-53-4 (S)-1-(4-苄氧基-3-... | CAS号188690-82-6 (R)-1-(4-苄氧基-3-... | CAS号515152-69-9 4-ethenyl-2-nit...

氯化苄置于溴,Potassium Carbonate体系中,用 水,溶剂黄146,丙酮 作为反应溶剂,化学反应生成 3'-硝基-4'-苄氧基-2-溴苯乙酮
参考文献:Design,Synthesis And Evaluation Of Dual Pharmacology β2-Adrenoceptor Agonists And Pde4 Inhibitors
标题:Design,Synthesis And Evaluation Of Dual Pharmacology β2-Adrenoceptor Agonists And Pde4 Inhibitors
摘要:A Novel Series Of Formoterol-Phthalazinone Hybrids Were Synthesised And Evaluated As Dual Pharmacology Beta(2)-Adrenoceptor Agonists And Pde4 Inhibitors. Most Of The Hybrids Displayed High Beta(2)-Adrenoceptor Agonist And Moderate Pde4 Inhibitory Activities. The Most Potent Compound,(R,R)-11C,Exhibited Agonist (Ec50 = 1.05 Nm,Pec(50) = 9.0) And Potent Pde4B2 Inhibitory Activities (Ic50 = 0.092 Mu M). (C) 2013 Published By Elsevier Ltd.
DOI:10.1016/j.Bmcl.2013.11.028

专利信息

专利号:US-9029421-B2
优先权日:2008-06-02
标 题 :Process for the synthesis of arformoterol
发明人：HALDAVANEKAR VAISHALI VAMAN; PRABHU MANGESH; RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO
权利人:HALDAVANEKAR VAISHALI VAMAN; PRABHU MANGESH; RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; CIPLA LTD
摘要:The present invention provides a process for preparing a compound of formula (VI) or a salt thereof, the process comprising: (i) reacting 4-methoxyphenyl acetone with an amine of formula (VIII) under conditions of reductive amination to produce a compound of formula (II) or a salt thereof, wherein there is no isolation of an imine intermediate formed during the reductive amination; (ii) condensing the compound (II) or the acid addition salt thereof with an α-haloketone of formula (III) to produce the compound of formula (IV); (iii) reducing the compound (IV) to a compound of formula (V); and (iv) reducing the compound (V) to the compound of formula (VI), wherein the reduction is carried out in the presence of either (1) a hydrogen donating compound in the presence of a hydrogen transfer catalyst; or (2) ammonium formate using a hydrogenation catalyst, wherein R 1 and R 2 are independently optionally substituted arylalkyl, and Hal is selected from chloro or bromo.

专利号:US-2015210629-A1
优先权日:2008-06-02
标题 :Process for the Synthesis of Arformoterol

专利号:KR-20110015449-A
优先权日:2008-06-02
标题:Process for the synthesis of arformoterol

专利号:EP-2285770-B1
优先权日:2008-06-02
标 题 :Process for the synthesis of arformoterol

专利号:EP-2285770-A1
优先权日:2008-06-02
标 题 :Process for the synthesis of arformoterol

专利号:WO-2009147383-A1
优先权日:2008-06-02
标 题 :Process for the synthesis of arformoterol