CAS: 35081-45-9; 4'-(Benzyloxy)-2-Bromopropiophenone

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CAS号4495-66-3 4'-苄氧基苯丙酮 | CAS号70-70-2 4-羟基苯丙酮; 对羟基苯丙酮 | CAS号637-27-4 丙酸苯酯 | CAS号100-39-0 溴化苄 | CAS号198479-82-2 ethyl 2-[4-[[3-... | CAS号198479-63-9 3-甲基-5-苄氧基-2-(4... | CAS号198481-32-2 1-[[4-[2-(氮杂环庚烷... | CAS号35133-39-2 1-[4-(phenylmet... | CAS号198480-21-6 1-[4-(2-(氮杂环庚烷-... | CAS号62634-51-9 2-(benzylamino)... | CAS号52446-73-8 2-[[2-(4-羟基苯基)乙...

溴甲苯置于溴,Potassium Carbonate,溶剂黄146体系中,用 丙酮 作为反应溶剂,化学反应 19.0H,反应生成 4'-苯甲氧基-2-溴苯丙酮
参考文献:3-甲基-2-苯基-1H-吲哚的合成,抗增殖作用和拓扑异构酶ii抑制活性.
标题:3-甲基-2-苯基-1H-吲哚的合成,抗增殖作用和拓扑异构酶ii抑制活性.
摘要:制备了一系列3-甲基-2-苯基-1H-吲哚,并研究了其对三种人类肿瘤细胞hela,A2780和msto-211H的抗增殖活性,并绘制了一些构效关系.在所有测试的细胞系中,最有效的化合物(32和33)的gi50值均低于5μm.对于生物学上最相关的衍生物,研究了其对人dna拓扑异构酶ii松弛活性的影响,突出了抗增殖作用与拓扑异构酶ii抑制之间的非常好相关性.已显示最有效的衍生物32诱导凋亡途径.所获得的结果突出了3-甲基-2-苯基-1H-吲哚作为有前途的支架,用于进一步优化具有有效的抗增殖和抗拓扑异构酶ii活性的化合物.
DOI:10.1021/acsmedchemlett.9B00557

专利信息

专利号:US-7968732-B1
优先权日:2010-09-07
标 题 :Process for the preparation of 5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1H-indole
发明人：DIVI MURALI KRISHNA PRASAD; RAO BOLINENI NAGESWARA; SURESH DANDU VENKATA
权利人:DIVIS LAB LTD
摘要:The present invention is related to a process for the preparation of 5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1H-Indole (formula-1, a useful intermediate for the synthesis of bazedoxifene) using 4-benzyloxy propiophenone and 4-benzyloxy phenyl hydrazine hydrochloride.

专利号:US-10844047-B2
优先权日:2018-06-21
标题:Process for the preparation of bazedoxifene
发明人：FERRARI MASSIMO; ZANI DANIELE DE; VEZZOSI STEFANO; BELOTTI PAOLO
权利人:ERREGIERRE SPA
摘要:The invention relates to a process for preparation of the compound 3-methyl-5-benzyloxy-2-(4-benzyloxyphenyl)-1H-indole 5, an intermediate for the synthesis of bazedoxifene and bazedoxifene acetate.

专利号:EP-1025077-B1
优先权日:1997-10-15
标题 :Novel aryloxy-alkyl-dialkylamines
发明人：RAVEENDRANATH PANOLIL; ZELDIS JOSEPH; VID GALINA; POTOSKI JOHN RICHARD; REN JIANXIN
权利人:WYETH CORP
摘要:The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having formula (I) wherein: R?1 and R2¿ are, independently, selected from H; C¿1?-C12 alkyl or C1-C6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R?3, R4, R5, and R6¿ are independently selected from H, halogen, -NO¿2?, alkyl, alkoxy, C1-C6 perfluorinated alkyl, OH or the C1-C4 esters or alkyl ethers thereof, -CN, -O-R?1¿, -O-Ar, -S-R1, -S-Ar, -SO-R1, -SO-Ar, -SO¿2?-R?1, -SO¿2-Ar, -CO-R1, -CO-Ar, -CO¿2-R?1, or -CO¿2?-Ar; and Y is selected from a) the moiety (i) wherein R7 and R8 are independently selected from the group of H, C1-C6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated or partially unsaturated heterocycle or bicyclic heterocycle containing up to two heteroatoms selected from the group consisting of -O-, -NH-, -N(C1C4 alkyl)-, -N=, and -S(O)n-.

专利号:US-6268504-B1
优先权日:1997-10-15
标题 :Aryloxy-alkyl-dialkylamines
发明人：RAVEENDRANATH PANOLIL; ZELDIS JOSEPH; VID GALINA; POTOSKI JOHN R; REN JIANXIN; IERA SILVIO
权利人:AMERICAN HOME PROD
摘要:The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula:wherein: R1 and R2 are, independently, selected from H; C1-C12 alkyl or C1-C6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R3, R4, R5, and R6 are independently selected from H, halogen, -NO2, alkyl, alkoxy, C1-C6 perfluorinated alkyl, OH or the C1-C4 esters or alkyl ethers thereof, -CN, -O-R1, -O-Ar, -S-R1, -S-Ar, -SO-R1, -SO-Ar, -SO2-R1, -SO2-Ar, -CO-R1, -CO-Ar, -CO2-R1, or -CO2-Ar; and Y is selected from a) the moiety:wherein R7 and R8 are independently selected from the group of H, C1-C6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated or partially unsaturated heterocycle or bicyclic heterocycle containing up to two heteroatoms selected from the group consisting of -O-, -NH-, -N(C1C4 alkyl)-, -N=, and -S(O)n-.