CAS: 31373-65-6; (S)-2-((S)-2-(2-Benzamidoacetamido)-3-(1H-Imidazol-4-yl)Propanamido)-4-Methylpentanoic Acid

上下游产品

CAS号495-69-2 马尿酸 | CAS号7763-65-7 H-HIS-LEN-OH | CAS号495-69-2 马尿酸 | CAS号7763-65-7 H-HIS-LEN-OH

📜马尿酸,L-组氨酰-L-亮氨酸置于angiotensin I Converting Enzyme体系中,用 水,二甲基亚砜 作为反应溶剂,化学反应生成 马脲酰组氨酰亮氨酸hhl
参考文献:Novel Fluorogenic Substrates Containing Bimane System For Microdetermination Of Angiotensin I Converting Enzyme.
标题:Novel Fluorogenic Substrates Containing Bimane System For Microdetermination Of Angiotensin I Converting Enzyme.
摘要:作为一种灵敏的荧光分析法,用于检测血管紧张素转化酶活性的含吲哚乙酸的联苯胺肽,即1,7-二氧-2,5,6-三甲基-1H,7H,吡唑[1,2-α]吡唑-3-基-甲硫甲酰基-甘氨酰(或l-苯丙氨酰)-L-色氨酰-L-亮氨酸(或l-脯氨酸),已被合成,并被证明是用于微量测定血管紧张素i转化酶活性的强效荧光底物.
DOI:10.1248/cpb.37.145

专利信息

专利号:US-2004033532-A1
优先权日:2002-08-08
标题 :Use of three-dimensional crystal structure coordinates to design and synthesize domain-selective inhibitors for angiotensin-converting enzyme (ACE)
发明人：EHLERS MARIO R W; HOLMQUIST BARTON
摘要:It has now been discovered that the use of the three-dimensional crystal structure coordinates of angiotensin-converting enzyme (ACE) will enable the design and synthesis, by means of computational chemistry and structure-guided drug design, of inhibitors of ACE that are highly selective and specific for either the N domain or the C domain of the enzyme, for the treatment of diverse diseases. The invention also relates to methods and processes for the structure-guided design and synthesis of dual N- and C-domain ACE inhibitors, and inhibitors that operate by competitive, non-competitive, uncompetitive, and irreversible mechanisms.

专利号:US-7951834-B2
优先权日:2005-05-27
标题 :Angiotensin I-converting enzyme (ACE) inhibitors
发明人：STURROCK EDWARD; NCHINDA ALOYSIUS; CHIBALE KELLY
权利人:UNIV CAPE TOWN
摘要:This invention relates to a process for the synthesis of ketomethylene derivatives of the tripeptide Phe-Gly-Pro (“keto-ACEâ€?, compound 5 a ) and analogues thereof. The synthesis process proceeds via an α,β-unsaturated keto intermediate. A key feature of the process involves a Horner-Emmons olefination of the, -unsaturated keto-phosphonate with ethyl glyoxylate. Keto-ACE analogues produced by the process of the invention display C-domain selectivity.

专利号:US-4410520-A
优先权日:1981-11-09
标题 :3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
发明人：WATTHEY JEFFREY W H
权利人:CIBA GEIGY CORP
摘要:Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzaz epin-2-ones and functional derivatives are angiotension converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.

专利号:SU-1709912-A3
优先权日:1986-01-06
标题 :Method for the synthesis of 4-phenylbutylphosphonic acid proline-containing ester

专利号:RU-2012556-C1
优先权日:1988-09-05
标 题:Method of synthesis of cycloalkylglutaramide derivatives or theirs pharmaceutically acceptable salts

专利号:US-6998259-B1
优先权日:1999-05-20
标题:Enzymatic treatment of whey proteins for the production of antihypertensive peptides and the resulting products
发明人：DAVIS MARTIN E; RAO ANAND; GAUTHIER SYLVIE; POULIOT YVES; GOURLEY LINE; ALLAIN ANNE-FRANCOISE
权利人:DAVISCO FOODS INTERNAT
摘要:Enzymatic digests of whey protein concentrates were prepared using animal, bacterial and fungal proteases, and evaluated for antihypertensive activities. The highest ACE-inhibitory activity was obtained with the purified peptide β-1g (f142–148) obtained by chemical synthesis, for which an IC 50 value of 0.04 mg powder.ml −1 was found. The hydrolysates derived from BiPROâ„¢ whey protein isolate and β-1g both gave higher antihypertensive activities (IC 50 values of 0.29 to 0.90 mg powder.ml −1 ) than the other hydrolysates tested (IC 50 values of 0.96 and 1.30 mg powder.ml −1 ). The recovered hydrolysate can be used to treat hypertension in mammals such as humans and domestic pets such as dogs and cats.