CAS: 2316-64-5; 4-Bromo-2-(Hydroxymethyl)Phenol

上下游产品

CAS号1761-61-1 5-溴水杨醛 | CAS号89-55-4 5-溴水杨酸 | CAS号90-01-7 2-羟基苄醇 | CAS号82944-17-0 6-bromo-2,2-dim... | CAS号50-00-0 甲醛 | CAS号106-41-2 对溴苯酚 | CAS号5532-69-4 4-bromo-2-(hydr... | CAS号7647-01-0 盐酸 | CAS号7732-18-5 水 | CAS号149489-18-9 5-BROMO-2-ETHOX... | CAS号202001-83-0 7-bromo-1-oxasp... | CAS号80866-82-6 5-溴-2-甲氧基苯甲醇 | CAS号7062-40-0 2-(5-溴-2-甲氧基苯基)乙氰 | CAS号7017-48-3 5-溴-2-甲氧基苯乙酸 | CAS号2362-12-1 4-溴-2-甲基苯酚 | CAS号177759-46-5 (2-(BENZYLOXY)-... | CAS号2635-13-4 1-溴-3,4-(亚甲基二氧基)苯 | CAS号1761-61-1 5-溴水杨醛 | CAS号21243-72-1 4-(hydroxymethy...

📜5-溴水杨酸置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 用作溶剂,化学反应生成5-溴-2-羟基苯甲醇
参考文献:协同手性伯胺/钯催化的不对称retro-Claisen反应.
标题:协同手性伯胺/钯催化的不对称retro-Claisen反应.
摘要:我们在本文中描述了β-二酮与水杨酸盐碳酸酯的手性伯胺/钯催化的不对称逆克莱森反应.通过一系列脱羧苄基化,逆克莱森裂解和烯胺质子化反应,获得了一系列具有非常好收率和优异对映选择性的手性α-烷基化酮和大环内酯.该策略具有广泛的底物范围,温和的条件以及以水杨酸碳酸酯为邻醌甲基化物前体的高原子经济性.
Doi:10.1021/acs.Orglett.9B02491

专利信息

专利号:US-8546532-B2
优先权日:2008-04-17
标题:Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders
发明人：BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS
权利人:BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS; DECLION PHARMACEUTICALS INC
摘要:The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.

专利号:US-2024287041-A1
优先权日:2021-05-20
标题 :Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms
发明人：BALOGLU ERKAN; AUSTAD BRIAN C; ROE DAVID G; KEDUC ANDREW; GOTTSCHLING STEPHEN EDMUND; HECKER EVAN
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The present invention relates to a method of preparing a compound represented by structural formula (VII), comprising reacting a compound represented by structural formula (II), with a compound represented by structural formula (III), in a solvent, in the presence of a Pd catalyst and one or more inorganic bases under conditions suitable to prepare a compound represented by structural formula (VII): The values and example values of the variables in structural formulas (VII), (II), and (III) are defined herein. The present invention also relates to crystalline Forms I and II of the compound represented by Structural Formula (VII), the use of the crystalline Forms in treating disease or disorders associated with CRM1 and method of preparing the crystalline Forms.

专利号:AU-2022276509-A1
优先权日:2021-05-20
标题:Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).

专利号:WO-2022246227-A1
优先权日:2021-05-20
标 题:Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms

专利号:US-10363247-B2
优先权日:2015-08-18
标 题:(S,E)-3-(6-aminopyridin-3-yl)-N-((5-(4-(3-fluoro-3-methylpyrrolidine-1-carbonyl)phenyl-7-(4-fluorophenyl)benzofuran-2-yl)methyl)acrylamide for the treatment of cancer
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted benzofuranyl compounds and, more particularly, to a compound represented by Structural Formula 1a: (I) or a pharmaceutically acceptable salt thereof. The invention also includes the synthesis and use of the compound of Structural Formula 1a, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of diseases or disorder selected from cancer (e.g., lymphoma, such as mantle cell lymphoma), a neurodegenerative disease, an inflammatory diseases or an immune system disease (e.g., a T-Cell mediated autoimmune disease) in a subject in need thereof. The method comprises administering to a subject in need thereof a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof, or a composition comprising a compound of the invention, or a pharmaceutically acceptable salt thereof.