CAS: 2243-83-6; 2-Naphthoyl Chloride

该化合物是源自氯化萘的芳香芳烃氯化物,其第二个位置是用碳基氯化物组替换的环环,该化合物一般是无色的,可粉色的黄色液体,以其强势,发光的气味闻名;该化合物反应性很强,特别是水,导致在水解中形成2-纳phoic酸;2-纳phyl氯化物在二氯甲烷和乙醚等有机溶剂中溶解,但由于其湿性氯化萘结构,在水中无法溶解;该化合物通常用于有机合成,特别是在制作环球衍生物时,并在各种化学反应中用作一种碳基剂;在处理该化合物时,安全防范措施至关重要,因为它可能会对皮肤,眼睛和呼吸道产生严重刺激.适当储存在冷,干燥的地方,远离水分和不相容物质,对于保持其稳定性和再活动至关重要.

结构式图片

相似化合物

2351-36-2 879-18-5 66-99-9

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号93-09-4 2-萘甲酸 | CAS号532-02-5 2-萘磺酸钠 | CAS号613-46-7 2-萘甲腈 | CAS号111876-50-7 4-naphthalen-2-... | CAS号105855-20-7 ethyl 1-(naphth... | CAS号107574-57-2 2-methyl-1-naph... | CAS号110876-52-3 2-甲基-1,2'-二萘酮 | CAS号39627-84-4 2-萘甲酰肼 | CAS号362669-46-3 ETHYL 8-(2-NAPH... | CAS号362669-52-1 8-(2-NAPHTHYL)-... | CAS号66832-24-4 2-[(trichlorome... | CAS号580-13-2 2-溴萘 | CAS号14625-56-0 2-naphthalen-2-...

合成工艺路线路线简述

  • 合成目标产物 2-Naphthoyl Chloride 主要起始原料 2-Naphthoic Acid
  • (文献来源)合成步骤主要原料 2-Naphthoic Acid
2-萘甲腈置于五氯化磷,Potassium Carbonate体系中,化学反应生成2-萘甲酰氯
参考文献:Vieth,Justus Liebigs Annalen Der Chemie,1876,Vol. 180,P. 305
标题:Vieth,Justus Liebigs Annalen Der Chemie,1876,Vol. 180,P. 305

海关参考信息

专利信息


专利号:US-11926589-B2
优先权日:2019-07-09
标 题 :Process for the synthesis of non-racemic cyclohexenes
发明人:REISMAN SARAH; ROMBOLA MICHAEL; LADD CAROLYN L; MCLAUGHLIN MARTIN JOHN; ZUEND STEPHAN; GOETZ ROLAND
权利人:BASF CORP; CALIFORNIA INST OF TECHN
摘要:This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and Y have the meanings as defined in the description in the presence of a catalyst comprising at least one m-valent metal cation M m+ wherein the metal M is selected from Scandium (Sc), Yttrium (Y), Lanthanum (La), Cerium (Ce), Praseodymium (Pr), Neodymium (Nd), Promethium (Pm), Samarium (Sm), Europium (Eu), Gadolinium 15 (Gd), Terbium (Tb), Dysprosium (Dy), Holmium (Ho), Erbium (Er), Thulium (Tm), Ytterbium (Yb), Lutetium (Lu), Gallium (Ga) and Indium (In), and m is an integer of 1, 2 or 3, and a chiral ligand of the formula (IV) wherein R 10a , R 10b , R 10c , R 10d , R 10a′ , R 10b′ , R 10c′ , R 10d′ , Z and Z′ have the meanings as defined in the description.

专利号:US-6608196-B2
优先权日:2001-05-03
标题 :Process for solid supported synthesis of pyruvate-derived compounds
发明人:WANG BING; JANAGANI SATYANARAYANA; CALLAWAY WYETH B; SESSLER JONATHAN L
权利人:GALILEO PHARMACEUTICALS INC
摘要:Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.

专利号:US-11981648-B2
优先权日:2019-06-13
标题:Method for the synthesis of 3-R-1,4,2-dioxazol-5-ones
发明人:HALL DAVID S; DAHN JEFFERY RAYMOND; HYNES TOREN
权利人:TESLA INC; PANASONIC HOLDINGS CORP
摘要:Provided are methods of preparing 3-R-1,4,2-dioxazol-5-one compounds using convenient and efficient methods. Also provided are 3-R-1,4,2-dioxazol-5-one compounds produced using the methods described.

专利号:US-2014046086-A1
优先权日:2012-08-10
标题:Process for the preparation of tafluprost and intermediates thereof
发明人:WEN WEN-HSIEN
权利人:SCINOPHARM CHANGSHU PHARMACEUTICALS LTD
摘要:The present invention provides efficient, economical and environmental friendly methods for synthesis of prostaglandin analogs including tafluprost and intermediates thereof. The invention involves a selective oxidation using in situ boronate ester protection and a unique crystallization method to remove the undesired isomers of fluorinated intermediates.

专利号:US-2014371316-A1
优先权日:2011-11-23
标 题:Derivatives of phenoxyisobutyric acid
发明人:LALEZARI IRAJ; FABRICANT JILL S
权利人:FABRICANT JILL S; LALEZARI IRAJ
摘要:The present invention provides a process for the synthesis of substituted phenoxymethylpropiomc acid and related compounds. The compounds are useful for inhibiting the formation of AGEs (Advanced Glycation End Products).

专利号:WO-2021081881-A1
优先权日:2019-10-31
标 题 :Functional carbohydrate molecule based on tdg molecular scaffold, and preparation method therefor
发明人:LI WEI; WANG HUAIYU
权利人:SHENZHEN INST ADV TECH
摘要:The present invention provides a carbohydrate compound, the structure of which is as represented by formula X, wherein R 1 and R 2 are independently selected from a substituted amido group, a substituted triazolyl group, and a substituted amino group; R 3 is selected from a sulfhydryl group, an azido group, an amino group, and a carboxyl group; A is formula aa or -C m H 2m R 3 , wherein X is selected from an oxygen atom; n is selected from 0, 1, 2, 3, 4, 5, 6, and 7; m is selected from 2, 3, 4, 5, 6, 7, 8, 9, and 10. In the present invention, a synthesis strategy of 'first side chain derivatization, then glycosylation coupling' is adopted, thereby achieving side chain derivatization modification of a TDG molecular scaffold and efficient synthesis of the compound . In the present invention , the use of the recognition and binding of a TDG glycoligand molecule to a target protein has a targeting function of identifying and binding to the target protein, and the TDG glycoligand molecule is used as a targeting molecule to construct a functional targeting molecule; the present invention has a wide application prospect in the fields such as tumor detection and tumor immunity.
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合成参考文献


参考文献:10.1007/128_2011_200
摘要:Miller BL. DCC in the development of nucleic acid targeted and nucleic acid inspired structures. Top Curr Chem. 2012;322():107–37. doi: 10.1007/128_2011_200.
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