CAS: 21667-61-8; 3-Fluorobenzoylacetonitrile

该化合物是一种该化合物是一种苯共蕾联苯基脊柱,在元体位置上有一个氟替代物.这种结构改变增强了其回活动性和选择性,使其成为制药和农用化学合成中有价值的中间体.氟共聚物在目标分子中带来了更好的代谢稳定性和结合性,而硝三联苯组则提供了进一步功能化的多功能性.其高纯度和持续的质量确保了交叉反应,循环和其他精细化学工艺的可靠性能.适合研究和工业应用的3-Fluorobenzoylacetrile是开发氟化外循环和生物活性化合物的关键建筑块.

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上下游产品

2-bromo-1-(3-fluorophenyl)ethanone sodium cyanide 1-(3-fluorophenyl)ethanone methyl 3-fluorobenzoate 5-(3-fluoro-phenyl)-2H-pyrazol-3-ylamine 9H8FN°C9H8FNO 2-(3-fluorophenyl)-1,5-naphthyridine-3-carbonitrile

合成工艺路线路线简述

  • 合成目标产物 3-Fluorobenzoylacetonitrile 主要起始原料 Methyl 3-Fluorobenzoate And Acetonitrile
  • (文献来源)合成步骤主要原料 Methyl 3-Fluorobenzoate 和 Acetonitrile
📜3'-氟苯乙酮置于溴体系中,用 乙醚,乙醇,水 用作溶剂,化学反应生成3-氟苯甲酰乙腈
参考文献:3-Substituted-(5-Arylfuran-2-Ylcarbonyl)Guanidines As Nhe-1 Inhibitors
标题:3-Substituted-(5-Arylfuran-2-Ylcarbonyl)Guanidines As Nhe-1 Inhibitors
摘要:The C-3 Substituents Effect On Nhe-1 Inhibitory Activity Of (5-Arylfuran-2-Ylcarbonyl)Guanidines,Previously Identified As Potent Nhe-1 Inhibitors,Was Investigated. The Introduction Of Amine Or Alkyl Groups At The 3-Position Of The Furan Ring,Next To The Acylguanidine Moiety,Remarkably Improves Nhe-1 Inhibitory Potency. Especially The Important Finding Is That 5-(2,5-Dichloro)Phenyl And 5-(2-Methoxy-5-Chloro)Phenyl Derivatives Exhibit High Nhe-1 Inhibitory Activities (Ic50 < 0.02 Microm) That Match Those Of 3-Unsubstituted Derivatives.
Doi:10.1016/j.Bmcl.2006.12.012

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主要参考文献

参考标题:Rh(III)-Catalyzed C-H Activation Of Benzoylacetonitriles And Tandem Cyclization With Diazo Compounds To Substituted Benzo[De]Chromenes
作者:Feifei Fang,Chunmei Zhang,Chaofan Zhou,Yazhou Li,Yu Zhou,Hong Liu |发布日期:2018.4.6
摘要:Rh (III)-Catalyzed C-H Activation Of Benzoylacetonitriles In Coupling With Diazo Compounds Was Developed To Synthesize Diversified Substituted Benzo[de]Chromenes Via A Formal (4 + 2) Cycloaddition With A Diazo Compound And Subsequent Tandem (4 + 2) Cycloaddition With Another Diazo Compound. Intriguingly, Synthesis Of Substituted Benzo[de]Chromenes And Their Decarboxylation Products Could Be Realized

合成参考文献


参考文献:10.1021/jm00197a020
摘要:Ridge DN, Hanifin JW, Harten LA, Johnson BD, Menschik J, Nicolau G, Sloboda AE, Watts DE. Potential antiarthritic agents. 2. Benzoylacetonitriles and beta-aminocinnamonitriles. J Med Chem. 1979 Nov;22(11):1385–9. doi: 10.1021/jm00197a020.
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