CAS: 2009-24-7; 9-Hydroxy-7H-Furo[3,2-G]Chromen-7-One

该化合物是一种自然发生的化合物,被归类为呋喃,主要来源于阿皮塞亚家族的植物,主要来源于诸如*帕斯蒂那卡沙丁瓦* (Wild parsnip) 和* Angelica* 等物种.Xanthotoxol的特征是其复杂的结构,其中包括一个与coumarin mosoity结合的松鼠环.该化合物展示了一系列生物活动,包括潜在的抗微生物和抗炎特性.它也以光毒性效应为名,在阳光照射时可导致皮肤反应.从溶性来看,Xanthotoxol一般在有机溶剂中溶解,但在水中的溶解性有限.它的应用范围扩大到传统医学和研究,研究其药效潜力.然而,由于它的光毒性和可能对敏感个人造成有害影响,因此谨慎行事.总的来说,Xanthoxol是天然产品和医学领域的一个令人感兴趣的研究课题.

结构式图片

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298-81-7 66-97-7 484-20-8

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上下游产品

9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one imperatorin xanthotoxol 8-O-β-D-glucopyranoside wampetin9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one imperatorin O-acetylxanthotoxol 9-(phenylmethoxy)-7H-furo[3,2-g][1]benzopyran-7-one

合成工艺路线路线简述

    📜欧前胡素置于硫酸体系中,用 四氢呋喃,水 用作溶剂,化学反应 6.0H,反应生成花椒毒醇
    参考文献:Cinamic Compounds And Derivatives Therefrom For The Inhibition Of Histone Deacetylase
    标题:Cinamic Compounds And Derivatives Therefrom For The Inhibition Of Histone Deacetylase
    摘要:该发明涉及以下式(I)所表示的化合物及其药学上可接受的盐,立体异构体,对映异构体,前药和溶剂合物.这些化合物可用作增强神经突起生长的药剂,并预防或治疗与hdac特别相关的疾病,如肿瘤或细胞增殖性疾病.具体来说,该发明的化合物可用作抗癌,抗糖尿病和抗神经退行性疾病的药剂,如阿尔茨海默病,亨廷顿病,脊髓小脑共济失调(sca)和人类脊髓肌肉萎缩症(sma)的药剂.

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    专利信息


    专利号:US-4429138-A
    优先权日:1977-10-21
    标题 :Process for the synthesis of 5-methoxy-psoralen
    发明人：GOUPIL JEAN-JACQUES
    权利人:GOUPIL JEAN JACQUES
    摘要:A pharmaceutical formulation comprising 5-methoxy psoralen, which is useful in the treatment of psoriasis and other skin disorders, is disclosed herein. 5-Methoxy psoralen may be synthesized from phloroglucinol by a five step process which is also disclosed.

    专利号:CN-110184247-B
    优先权日:2019-05-09
    标 题:Melatonin synthesis gene MsASMT in alfalfa and its application in regulating the synthesis of melatonin and flavonoids in plants

    专利号:CN-110184247-A
    优先权日:2019-05-09
    标题 :Alfalfa melatonin synthesis gene MsASMT and its application in regulating the synthesis of melatonin and flavonoids in plants

    专利号:EP-2153815-A1
    优先权日:2008-08-05
    标题 :Use of urea containing compositions
    发明人：TRULLAS CABANAS CARLOS RAMON; KRUTMANN JEAN PROF DR
    权利人:ISDIN SA
    摘要:The present invention relates to the use of a composition comprising urea for increasing the expression of at least one gene associated with the collagen synthesis within the dermis of the skin. nThe urea composition has been used for preventing/treating damages of the skin such as signs of aging, wrinkles, damages associated with UV-radiation, wounds, skin diseases.

    专利号:US-2007065377-A1
    优先权日:2003-10-17
    标题 :Composition for promoting synthesis of collagen, and composition for external preparation for skin comprising the same

    专利号:WO-2005037270-A1
    优先权日:2003-10-17
    标题:Composition for promoting synthesis of collagen, and composition for external preparation for skin comprising the same

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    主要参考文献


    1: Bai Y, Ouyang H, Liu Y, Zuo F, Li C, Zhou S, Chang Y, He J. Application of UPLC-MS/MS to Study Cellular Pharmacokinetics of Seven Active Components of Cnidii Fructus Extracts. Curr Drug Metab. 2025;25(8):576-585. doi: 10.2174/0113892002301262241107065717.
    204:108142. doi: 10.1016/j.plaphy.2023.108142. Epub ahead of print.
    15:1396001. doi: 10.3389/fphar.2024.1396001.

    合成参考文献


    摘要:Journal of Ethnopharmacology., 36(239), 1992 []
    参考文献:10.1385/1-59259-676-2:49
    摘要:Wang Z, Rana TM. Probing RNA-protein interactions by psoralen photocrosslinking. Methods Mol Biol. 1999;118():49–62. doi: 10.1385/1-59259-676-2:49.
    参考文献:10.1016/j.jpba.2005.10.033
    摘要:Chen Y, Fan G, Chen B, Xie Y, Wu H, Wu Y, Yan C, Wang J. Separation and quantitative analysis of coumarin compounds from Angelica dahurica (Fisch. ex Hoffm) Benth. et Hook. f by pressurized capillary electrochromatography. Journal of Pharmaceutical and Biomedical Analysis. 2006 Apr;41(1):105–16. doi: 10.1016/j.jpba.2005.10.033.
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