CAS: 19983-44-9; 6-Nitrobenzo[b]Thiophene 1,1-Dioxide

该化合物是一个化学化合物,其作用是选择性抑制酶弧的蛋白质动脉活性,主要用于生物化学研究,研究细胞信号路径和弧弧抑制对各种生物过程的影响,其特征是它能够破坏弧信号路径,它涉及许多细胞功能,包括扩散,生存和迁移.该化合物通常用于实验室环境,其效力可因具体细胞类型和实验条件而不同.与许多化学物质一样,在处理统计时,应注意安全防范措施,包括使用适当的个人防护设备,遵守安全数据表准则.其研究应用有助于更好地了解癌症生物学和针对弧线的治疗战略.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号825-44-5 苯并[b]噻吩 1,1-二氧化物 | CAS号858819-40-6 6-nitro-1,1-dio... | CAS号857473-99-5 N-(1,1-dioxo-1λ... | CAS号850855-54-8 N-(6-nitro-1,1-... | CAS号95-15-8 苯并噻吩 | CAS号7697-37-2 硝酸 | CAS号20503-39-3 6-氨基-2,3-二氢苯并[b... | CAS号20503-40-6 6-氨基苯并噻吩-1,1-二氧烷 | CAS号54928-74-4 2,3-dihydro-1-b...

合成工艺路线路线简述

    📜N-(6-Nitro-1,1-Dioxo-1λ6-Benzo[b]Thiophen-5-yl)-Acetamide置于盐酸,硫酸,溶剂黄146,Sodium Nitrite体系中,化学反应生成6-硝基-1H-1Lambda~6~-苯并[b]噻吩-1,1-二酮
    参考文献:Benzothiophene Chemistry. Vii. Substitution Reactions Of 5-Hydroxy-And 5-Aminobenzothiophene Derivatives
    标题:Benzothiophene Chemistry. Vii. Substitution Reactions Of 5-Hydroxy-And 5-Aminobenzothiophene Derivatives
    摘要:
    Doi:10.1021/ja01627A048

    海关参考信息

    专利信息


    专利号:WO-2013001088-A1
    优先权日:2011-06-30
    标 题 :Direct synthesis of 18f-fluoromethoxy compounds for pet imaging and the provision of new precursors for direct radiosynthesis of protected derivatives of o-([18f]fluoromethyl) tyrosine

    专利号:EP-2751087-A1
    优先权日:2011-06-30
    标题 :Direct synthesis of 18f-fluoromethoxy compounds for pet imaging and the provision of new precursors for direct radiosynthesis of protected derivatives of o-([18f]fluoromethyl)tyrosine

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    主要参考文献


    1: Oleksak P, Rysanek D, Vancurova M, Vasicova P, Urbancokova A, Novak J, Maurencova D, Kashmel P, Houserova J, Mikyskova R, Novotny O, Reinis M, Juda P, Hons M, Kroupova J, Sedlak D, Sulimenko T, Draber P, Chlubnova M, Nepovimova E, Kuca K, Lisa M, Andrys R, Kobrlova T, Soukup O, Janousek J, Prchal L, Bartek J, Musilek K, Hodny Z. Discovery of a 6-Aminobenzo[b]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities. ACS Pharmacol Transl Sci. 2024 Aug 12;7(9):2755-2783. doi: 10.1021/acsptsci.4c00190.
    2: Dou J, Chen X, Zhang J, Yang L, Lin J, Zhu W, Huang D, Tan X. P. Gingivalis induce macrophage polarization by regulating hepcidin expression in chronic apical periodontitis. Int Immunopharmacol. 2024 Sep 14;142(Pt A):113139. doi: 10.1016/j.intimp.2024.113139. Epub ahead of print. 19(9):e0310120. doi: 10.1371/journal.pone.0310120.
    6: Zhong H, Wang L, Zhu X, Li S, Li X, Ding C, Wang K, Wang X. STAT3 inhibitor Stattic Exhibits the Synergistic Effect with FGFRs Inhibitor Erdafitinib in FGFR1-positive Lung Squamous Cell Carcinoma. J Cancer. 2024 Aug 19;15(16):5415-5424. doi: 10.7150/jca.97477.

    合成参考文献


    参考文献:10.4161/cc.23030
    摘要:Chen B, Liu J, Chang Q, Beezhold K, Lu Y, Chen F. JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic. Cell Cycle. 2013 Jan 01;12(1):112–21.
    参考文献:10.1161/hypertensionaha.111.00299
    摘要:Johnson AW, Kinzenbaw DA, Modrick ML, Faraci FM. Small-Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 Protect Against Angiotensin II–Induced Vascular Dysfunction and Hypertension. Hypertension. 2013 Feb;61(2):437–42. doi: 10.1161/hypertensionaha.111.00299.
    参考文献:10.18632/oncotarget.5861
    摘要:Zheng J, Park MH, Son DJ, Choi MG, Choi JS, Nam KT, Kim HD, Rodriguez K, Gann B, Ham YW, Han SB, Hong JT. (E)-4-(3-(3,5-dimethoxyphenyl)allyl)-2-methoxyphenol inhibits growth of colon tumors in mice. Oncotarget. 2015 Dec 08;6(39):41929–43.
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