CAS: 1865-01-6; 4-Nitrophenyl Formate

上下游产品

CAS号100-02-7 对硝基苯酚 | CAS号2258-42-6 甲乙酐 | CAS号64-18-6 甲酸 | CAS号26944-31-0 N,N-甲酰乙酰胺 | CAS号2565-30-2 formyl chloride | CAS号111333-97-2 五氟苯酚甲酸酯 | CAS号14609-74-6 Phenol, 4-nitro... | CAS号33104-36-8 2,4,5-TRICHLORO... | CAS号1544-86-1 4-(二氟甲氧基)硝基苯 | CAS号1864-94-4 羧酸苯甲酯 | CAS号37085-23-7 D-Glucose,2-deo... | CAS号111154-10-0 N-(2-anilinoeth... | CAS号1864-97-7 para-cresyl formate | CAS号717110-29-7 N-[2-(4-nitroan... | CAS号877134-48-0 N-[4-[4-(triflu...

对硝基苯酚,甲乙酐置于碳酸氢钠体系中,化学反应生成甲酸对硝基苯酯
参考文献:用于从苯酚和醇的芳族和脂族二氟甲基醚的使用氯/氟交换方法制备三步法
标题:用于从苯酚和醇的芳族和脂族二氟甲基醚的使用氯/氟交换方法制备三步法
摘要:二氟甲基醚是由苯酚通过它们各自的甲酸酯衍生物分三步制备的.的甲酸盐首先通过用五氯化磷转化为二氯甲基醚.然后,这些醚是诱导经历氯/氟交换,以形成相应的二氟甲基醚.氯/氟交换由或室温,用thf-5Hf或et溶剂化过程中进行3的n-3Hf作为交换介质,其中hf是氟的最终来源,或者通过在环丁砜在125°C,其中kf是氟源的直接位移过程.由一个或另一个这些过程中,几乎所有的酚和电子差富电子,可以在非常好的收益率转化为各自的二氟甲基醚.脂族醇也能够被转换为使用的et它们二氟甲基醚衍生物3的n-3Hf交换介质.
Doi:10.1016/j.Jfluchem.2014.01.018

专利信息

专利号:US-11542269-B2
优先权日:2018-01-03
标 题:Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHOI HYEONG-WOOK; FANG FRANCIS G
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods utilizing Prins reaction in the preparation of compounds that may be useful as intermediates in the synthesis of halichondrin macrolides and analogs thereof. The invention also provides compounds that may be useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-10913749-B2
优先权日:2015-05-07
标 题 :Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-11136335-B2
优先权日:2016-06-30
标题:Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHASE CHARLES E; CHOI HYEONG-WOOK; ENDO ATSUSHI; FANG FRANCIS G; KIM DAE-SHIK
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.

专利号:US-9783549-B2
优先权日:2013-11-04
标题:Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E; LEE JAEMOON
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.

专利号:US-2010087658-A1
优先权日:1996-08-06
标 题 :Methods and intermediates for synthesis of selective dpp-iv inhibitors
发明人：CAMPBELL DAVID ALAN; LEITAO EMILIA P T; WU ZHEN-PING; WANG PENG
权利人:PHENOMIX CORP
摘要:Methods and intermediates for the synthesis of selective inhibitors of dipeptidyl peptidase IV (DPP-IV) are provided. Coupling of a carboxylate salt with a boro-proline derivative provides a protected form of a DPP-IV inhibitor, which may be deblocked to yield the medicinal compound. The carboxylate salt can be a crystalline form of a sodium salt or a dicyclohexylammonium salt. The inhibitor can be used in the treatment of diabetes.

专利号:US-2024024497-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to methods for the synthesis of conjugates useful for the treatment of viral infections, e.g., conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir or an analog thereof) linked to an Fc domain monomer.