CAS: 1672-48-6; 6-Amino-5-Nitroso-2-Thioxo-2,3-Dihydropyrimidin-4(1H)-One

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CAS号78974-58-0 5H-Thiazolo[3,2... | CAS号1004-40-6 6-氨基-2-巯基嘧啶-4-醇

📜6-氨基-2-硫脲嘧啶置于溶剂黄146,Sodium Hydroxide,Sodium Nitrite体系中,化学反应生成6-氨基-5-亚硝基-2-硫脲嘧啶
参考文献:Synthesis,Experimental And Computational Studies Of N-(4-Amino-6-Oxo-1,6-Dihydropyrimidin-5-yl)Benzamide
标题:Synthesis,Experimental And Computational Studies Of N-(4-Amino-6-Oxo-1,6-Dihydropyrimidin-5-yl)Benzamide
摘要:背景:阻断 Kainate 受体是治疗神经退行性疾病(包括帕金森病)和癫痫的一种新兴策略.尤其是非竞争性的凯恩酸盐受体拮抗剂,因其非常好的安全性而大有可为.我们在此介绍 N-(4-氨基-6-氧代-1,6-二氢嘧啶-5-基)苯甲酰胺的合成,实验和计算研究. 方法:结果:对标题化合物进行的详细 X 射线研究证实了反应过程.标题化合物在三棱 P-1 空间群中结晶.不对称单元包括两个独立的化合物分子(a 和 B)和一个 Dmf 溶剂分子.势能分布(ped)分析有助于解释红外光谱.结论:标题化合物是一种表征非常好的中间体,它将被环化成次黄嘌呤衍生物,被设计为凯恩酸盐 Gluk1 和 Gluk2 受体的非竞争性拮抗剂.
Doi:10.2174/1570178614666170811123851

专利信息

专利号:US-7060818-B2
优先权日:2003-02-21
标题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process
发明人：HORWITZ COLIN P; GHOSH ANINDYA
权利人:UNIV CARNEGIE MELLON
摘要:An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the protected amino carboxylic acid to a first solvent, preferably a hydrocarbon solvent, such as toluene or 1,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane. The carboxylic acid portion of the protected amino carboxylic acid is then converted to an activated carboxylic acid by one of esterification or acid halide formation, to form a protected amino activated carboxylic acid derivative. The protected amino activated carboxylic acid derivative is reacted with a diamine in the presence of a second solvent, such as THF or ,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane, to form a protected diamide diamine intermediate. Following deprotection, the diamide diamine intermediate is reacted with an activated diacid, such as an activated malonate, oxalate or succinate derivative to form the macrocyclic tetraamido compound. The macrocyclic tetraamido compound may further be complexed with a transition metal.

专利号:WO-2004076425-A1
优先权日:2003-02-21
标题:Improved synthesis of macrocyclic tetraamido compounds and new metal insertion process