CAS: 147900-45-6; Cis-4-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)Cyclohexanecarboxylic Acid

该化合物是属于氨基酸类的化学化合物,经常用于peptide合成;FMOC(9-氟乙氧碳基)组作为氨基功能的保护组,允许在合成过程中有选择地作出反应;该组具有Cis-1,4-环氧环已烷结构的特点,有助于其独特的立体化学和再活动;其氢氧(-OH)组增强了极地溶剂的溶解性,使之适合各种生物化学应用;FMOC组的存在便于在温和基本条件下去除,便利了peptide合成过程中的保护过程;

结构式图片

相似化合物

147900-46-7 1776-53-0 27960-59-4

物理性质

MSDS等安全信息

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上下游产品

CAS号3685-23-2 4-氨基环己烷-1-羧酸 | CAS号82911-69-1 9-芴甲基-N-琥珀酰亚胺碳酸酯 | CAS号150-13-0 对氨基苯甲酸

合成工艺路线路线简述

    📜氯甲酸-9-芴基甲酯,(1R,4R)-4-Aminocyclohexanecarboxylic Acid置于potassium Carbonate体系中,用 1,4-二氧六环,水 用作溶剂,化学反应 21.0H,以59%的收率获得反式-4-(N-芴甲氧羰基氨基)环己烷甲酸
    参考文献:A Set Of Highly Sensitive Sirtuin Fluorescence Probes For Screening Small-Molecular Sirtuin Defatty-Acylase Inhibitors
    标题:A Set Of Highly Sensitive Sirtuin Fluorescence Probes For Screening Small-Molecular Sirtuin Defatty-Acylase Inhibitors
    摘要:
    Doi:10.1021/acsmedchemlett.1C00010

    海关参考信息

    专利信息


    专利号:US-8410028-B2
    优先权日:2003-12-17
    标 题:Methods for synthesis of encoded libraries
    发明人：MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
    权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
    摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

    专利号:US-2007042401-A1
    优先权日:2003-12-17
    标题 :Methods for synthesis of encoded libraries

    专利号:EP-3515880-B1
    优先权日:2017-03-17
    标题:Methods and compositions for synthesis of encoded libraries
    发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
    权利人:HITGEN INC

    专利号:US-2020149034-A1
    优先权日:2017-03-17
    标题:Methods and Compositions for Synthesis of Encoded Libraries

    专利号:US-2012245040-A1
    优先权日:2003-12-17
    标题 :Methods for synthesis of encoded libraries

    专利号:US-2009062147-A1
    优先权日:2003-12-17
    标 题:Methods for synthesis of encoded libraries

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    合成参考文献

    合成方法参考DOI号:10.1021/ja034440c
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