CAS: 146255-66-5; Dl-3,5-Dihydroxyphenylglycine

📜Kistamicin A置于盐酸,巯基乙酸体系中,化学反应 24.0H,以39 Mg的收率获得
参考文献:New Antiviral Antibiotics,Kistamicins A And B. Ii. Structure Determination.
标题:New Antiviral Antibiotics,Kistamicins A And B. Ii. Structure Determination.
摘要:抗病毒抗生素 Kistamicins A 和 B 的结构已通过化学降解和光谱分析的结合确定.它们通常由d-酪氨酸,3,5-二氢苯基甘氨酸,联苯醚双氨基酸和二苯基取代的吲哚三氨基酸组成,形成三环结构. Kistamicin B置于kistamicin A 的氨基末端具有苯乙酰胺.它们在结构上与万古霉素类抗生素的核相关,特别是与抗生素补体他汀相关.
Doi:10.7164/antibiotics.46.1812

专利信息

专利号:US-5648489-A
优先权日:1994-05-17
标题 :Syntheses of acyclic guanine nucleosides
发明人：CHU CHUNG K; DU JINFA; WANG CHUNGUANG
权利人:UNIV GEORGIA
摘要:A method is provided for the synthesis of synthesis of acyclic purine nucleosides, particularly 9-(2-hydroxy-ethoxymethyl)-guanine (acyclovir) and 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine ('DHPG') where the N2,N9-diprotected guanine is reacted with CH3C(O)OCH2O(CH2)2)OC(O)CH3 or 2-acetoxymethoxy-1,3-diacetoxypropane, respectively, in the presence of a mixture of an acid and acetic anhydride, or in the presence of an acid, where the acid can be phosphoric acid or polyphosphoric acid.

专利号:US-2018222848-A1
优先权日:2015-08-04
标 题:Salt of Dihydrophenylglycine Methyl Ester
发明人：VAN DER DOES THOMAS; MOODY HAROLD MONRO; LI WEIDONG
权利人:DSM SINOCHEM PHARM NL BV
摘要:The present invention relates to the hemi sulfuric acid salt of methyl (R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetate, also trivially referred to as the hemi sulfuric acid salt of D-dihydrophenylglycine methyl ester, to a method for the preparation of said salt and to the use of said salt in the enzymatic synthesis of antibiotics.

专利号:US-5780617-A
优先权日:1990-05-29
标题 :Synthesis of liponucleotides
发明人：VAN DEN BOSCH HENK; VAN WIJK GYSBERT M T; KUMAR RAJ; HOSTETLER KARL Y
权利人:NEXSTAR PHARMACEUTICALS INC
摘要:A process for the preparation of glycerol di- or triphosphate derivatives comprising coupling the phosphate group of a glycerol monophosphate derivative in which one of the phosphate hydroxyls is replaced by a leaving group, with the terminal phosphate group of a mono- or diphosphate compound or a salt thereof, in the presence of a basic catalyst, under anhydrous conditions.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:WO-9118914-A1
优先权日:1990-05-29
标题:Synthesis of glycerol di- and triphosphate derivatives
发明人：VEN DEN BOSCH HENK; VAN WIJK BERT; KUMAR RAJ; HOSTETLER KARL Y
权利人:VICAL INC
摘要:A process for the preparation of glycerophospholipid derivatives comprising coupling the phosphate group of a glycerol monophosphate derivative in which one of the phosphate hydroxyls is replaced by a leaving group, with the terminal phosphate group of a mono- or diphosphate compound or a salt thereof, in the presence of a basic catalyst, under anhydrous conditions.

专利号:US-2010247433-A1
优先权日:2005-10-14
标题:Use of non-canonical amino acids as metabolic markers for rapidly-dividing cells
发明人：TIRRELL DAVID; DIETERICH DANIELA C; LINK AARON J; SCHUMAN ERIN
权利人:CALIFORNIA INST OF TECHN
摘要:The invention provides methods, reagents and systems to preferentially mark fast-proliferating cells/tissues (such as cancer), by incorporating non-natural amino acids into proteins, preferably in vivo, using the endogenous protein synthesis machinery of an organism. The incorporated non-natural amino acids contain reactive groups for further chemical reagents, which may serve as a “handleâ€? to for a number of uses, such as imaging of cancer cells, targeting drugs to preferentially kill cancer cells, and proteomic analysis in the context of large scale or high throughput screening for candidate drug leads that affects the proliferation of a target cell, etc.