CAS: 1159977-58-8; (6-Hydroxy-2-(4-Hydroxyphenyl)Benzo[b]Thiophene-3,7-Diyl)Bis((4-(2-(Piperidin-1-yl)Ethoxy)Phenyl)Methanone)
该化合物是与Raloxifene制药剂有关的化学化合物,主要用于治疗和预防绝经后妇女骨质疏松症,并减少侵入性乳腺癌的风险.这种杂质具有一种苯并基组,它与管状丁基乙酰胺有关,有助于其结构复杂性.管状林环的存在表明它可能与生物目标发生相互作用,可能影响药用活动或毒性.作为杂质,它可能在合成Raloxifene期间产生,并可能影响最终药品产品的纯性和有效性.典型地说,它可能具有诸如有机溶剂溶解性,标准条件下的中度稳定性以及与其他化学物种的潜在再活动性等特性.了解这种杂质的特点对于制药生产的质量控制至关重要,确保治疗应用的安全和有效性.
- 英文名称(6-Hydroxy-2-(4-Hydroxyphenyl)Benzo[b]Thiophene-3,7-Diyl)Bis((4-(2-(Piperidin-1-yl)Ethoxy)Phenyl)Methanone)
- 中文名称7-[4-(2-哌啶基)乙氧基]苯甲酰基雷洛昔芬
- IUPAC名称(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3,7-diyl)bis((4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone)
- 其它别名Raloxifene Impurity I; 7-[4-(2-Piperidinyl)Ethoxy]Benzoyl Raloxifene (Raloxifene Impurity); [6-Hydroxy-2-(4-Hydroxyphenyl)-7-[4-(2-Piperidin-1-Yl-Ethoxy)Benzoyl]-Benzo[b]Thien-3-Yl]-[4-[2-(1-Piperidinyl)Ethoxy]Phenyl]Methanone; 7-[4-(2-Piperidinyl)Ethoxy]Benzoyl Raloxifene; Methanone, 1,1'-[6-Hydroxy-2-(4-Hydroxyphenyl)Benzo[b]Thiophene-3,7-Diyl]Bis[1-[4-[2-(1-Piperidinyl)Ethoxy]Phenyl]-; Raloxifene Hydrochloride Imp. A (Ep): 6-Hydroxy-2-(4-Hydroxyphenyl)-7-4-2-(Piperidin-1-yl)Ethoxy Benzoyl-1-Benzothiophen-3-Yl4-2-(Piperidin-1-yl)Ethoxy Phenylmethanone
- CAS编号1159977-58-8
- MFCD编号:MFCD21363793
- FDA UNII编号:POP5974Q1I
- 分子式:C42H44N2O6S分子量:704.89
- 产品CID: 202338
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
上下游产品
α-(3-methoxyphenyl-thio)-4-methoxyacetophenone 1-piperidinoethanol 3-methoxybenzenethiol合成工艺路线路线简述
📜3-甲氧基苯硫酚置于aluminum (III) Chloride,三溴化硼,Sodium Hydride,Potassium Hydroxide体系中,用 乙醇,二氯甲烷,水,N,N-二甲基甲酰胺,Mineral Oil 用作溶剂,化学反应 45.08H,反应生成7-[4-(2-哌啶基)乙氧基]苯甲酰基雷洛昔芬
参考文献:发现一类新的肝受体同源物-1 (Lrh-1) 拮抗剂:虚拟筛选,合成和生物学评价
标题:发现一类新的肝受体同源物-1 (Lrh-1) 拮抗剂:虚拟筛选,合成和生物学评价
摘要:靶向 Lrh-1:使用虚拟筛选和分子建模来确定肝受体同源物 1 (Lrh-1) 的新型拮抗剂,这是一种新兴的乳腺癌治疗靶点.合成命中化合物并进行生物学分析,初步结果表明,在苯并噻吩环的 C-7 位取代的基于雷洛昔芬的类似物可能通过结合产生无活性的蛋白质构象,从而拮抗这种核受体.
Doi:10.1002/cmdc.201200307
海关参考信息
- 2912110000-甲醛
2912210000-苯甲醛
2922110001-单乙醇胺
2922192100-二甲氨基乙醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6472531-B1
优先权日:1994-09-19
标题 :Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxybenzo[b]thiophenes
发明人：LABELL ELIZABETH SMITH; MCGILL JOHN MCNEILL; MILLER RANDAL SCOT
权利人:LILLY CO ELI
摘要:The present invention is directed to chemical processes for preparing 2-aryl-6-hydroxy-3-[4-(2-aminoethoxy)benzoyl]benzo[b]-thiophenes. The present invention is also directed to crystalline solvates and a non-solvated crystalline form of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]-benzo[b]thiophene hydrochloride, as well as processes for their preparation.
专利号:CA-2249406-A1
优先权日:1996-03-19
标 题:Synthesis of 3-¬4-(2-aminoethoxy)-benzoyl; -2-aryl-6-hydroxy-benzo¬b; thiophenes
专利号:SI-9500293-A
优先权日:1994-09-19
标 题 :Synthesis of 3-/4-(2-aminoethoxy)-benzoyl/-2- aryl-6-hydroxybenzo/b/ thyophenes
专利号:LV-11178-B
优先权日:1994-09-19
标 题 :Synthesis of 3-£4-(2-aminoethoxy) benzoyl; -2-aryl-6-hydroxybenzo £b; thiophenes
专利号:US-6399778-B1
优先权日:1994-09-19
标 题 :Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxybenzo[b]thiophenes
专利号:US-6008377-A
优先权日:1996-03-19
标题 :Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxy-benzo[B]thiophenes
发明人：JONES CHARLES D; MCGILL JOHN M
权利人:LILLY CO ELI
摘要:PCT No. PCT/US96/03934 Sec. 371 Date Aug. 21, 1998 Sec. 102(e) Date Aug. 21, 1998 PCT Filed Mar. 20, 1996 PCT Pub. No. WO97/34888 PCT Pub. Date Sep. 25, 1997The present invention is directed to chemical processes for preparing 2-aryl-6-hydroxy-3-[4-(2-aminoethoxyl)benzoyl]benzoyl]benzo[b]-thiophenes.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1021/acs.jmedchem.1c01663
摘要:Lang A, Isigkeit L, Schubert-Zsilavecz M, Merk D. The Medicinal Chemistry and Therapeutic Potential of LRH-1 Modulators. J Med Chem. 2021 Dec 09;64(23):16956–73. doi: 10.1021/acs.jmedchem.1c01663.
📝 需求与反馈
尽可能描述清楚需求与问题信息
