CAS: 95789-30-3; Cefotiam Hexetil Dihydrochloride
该化合物是长相脑膜胸叶素抗生素抗生素丙基磷酸丙基磺酰胺的一种药物.口服施药后,它进行水解以释放活性形式Cefotiam,该物质展示了对抗乳腺阳性和克阴性细菌的有力抗菌活动.Hexetel 酯会增加口服生物利用率,改善与母体化合物相比的系统吸收.这种配方能确保抗异体的一贯性能.Cefotiam Hexetil Hitrocl氯化物在治疗呼吸道,尿道和软组织感染方面特别有效,其稳定性和可预测的代谢性使它在临床环境中成为可靠的选择,提供了效果和耐受力的平衡.
- 英文名称Cefotiam Hexetil Dihydrochloride
- 中文名称头孢替安海替酯盐酸盐
- IUPAC名称5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)acetyl)amino)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, 1-(((cyclohexyloxy)carbonyl)oxy)ethyl ester, dihydrochloride, (6R-(6-alpha,7-beta))-
- 其它别名5-Thia-1-azabicyclo[4.2.0]°Ct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester, dihydr°Chloride, (6R,7R)-; 5-Thia-1-azabicyclo[4.2.0]°Ct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester, dihydr°Chloride, [6R-(6α,7β)]-; cefotiam hexetil hydr°Chloride; 1-cyclohexyloxycarbonyloxyethyl (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-(2-dimethylaminoethyl)tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]°Ct-2-ene-2-carboxylate dihydr°Chloride; (6R-(6-alpha,7-beta))-7-(((2-Amino-4-thiazolyl)acetyl)amino)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]°Ct-2-ene-2-carboxylic acid 1-(((cyclohexyloxy)carbonyl)oxy)ethyl ester dihydr°Chloride
- CAS编号95789-30-3
- MFCD编号:MFCD00897074
- EINECS号:680-797-5
- FDA UNII编号:3N1X7E8CLE
- 分子式:C27H38ClN9O7S3
- 分子量:732.29
- 产品CID: 2012320
- 同类组份化合物CAS95761-91-4 (free base)95789-30-3 (HCl)
- 产品分类原料药 → 抗生素类药物 → 头孢菌素类药
物理性质
MSDS等安全信息
欧盟法规
C&L通报合成工艺路线路线简述
- 99464-83-2 + 61622-34-2 = 95789-30-3
反应条件:1.1 Reagents: Sodium Iodide Solvents: Acetonitrile; 100 Min,50 °C1.2 Reagents: Potassium Carbonate Solvents: Acetone,Water; 40 Min,28 °C1.3 Solvents: Dichloromethane; 20 Min,-5 °C
标题:Method For Preparing And Purifying Cefotiam Hexetil Hydrochloride
参考文献:China]
99464-83-2 + 66309-69-1 = 95789-30-3
反应条件:1.1 Reagents: Sodium Iodide; 1.2 H; Rt -> 60 °C1.2 Reagents: Triethylamine; 15 Min,Reflux1.3 Reagents: Hydrochloric Acid; Ph 1 - 2,50 - 80 °C; 80 °C -> -25 °C
标题:One-Pot Method For Preparing Cefotiam Hexetil Hydrochloride
参考文献:China]
95761-91-4 = 95789-30-3
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 1 - 5 °C; 1 H,0 - 5 °C
标题:Method For Synthesis Of Low-Solvent-Residue Cefotiam Hexetil Hydrochloride
参考文献:China]
102672-57-1 = 95789-30-3
反应条件:1.1 Solvents: Dimethylformamide; 0.5 H,-20 - -15 °C1.2 Reagents: Sodium Pyrosulfite Solvents: Ethyl Acetate,Water; 20 Min1.3 Reagents: Hydrochloric Acid Solvents: Water; 5 Min,0 °C
标题:Method For Preparation Of Cefotiam Hexetil Hydrochloride With Cefotiam Hydrochloride
参考文献:China]
102672-57-1 + 66309-69-1 = 95789-30-3
反应条件:1.1 Reagents: Sodium Carbonate Solvents: Water; 1 H,Rt1.2 Solvents: Dimethylformamide; 12 Min,10 °C; Cooled1.3 Reagents: Hydrochloric Acid Solvents: Acetone,Water; 15 °C; 40 Min,15 °C; 25 Min,15 °C
标题:Method For Preparing Cefotiam Hexetil Hydrochloride From Cefotiam Salt
参考文献:China]
102672-57-1 = 95789-30-3
反应条件:1.1 Solvents: Dimethylformamide; 60 Min,-15 - -10 °C1.2 Reagents: Hydrochloric Acid Solvents: Isopropanol,Ethyl Acetate; -10 - -5 °C
标题:Method For Preparing Cefotiam Hexetil
参考文献:China
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2909110000-乙醚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6642377-B1
优先权日:1999-07-30
标 题 :Process for the preparation of basic antibiotic-inorganic acid addition salts and intermediate oxalates
发明人：KAYANO AKIO; CHIBA HIROYUKI; NAKAMURA TAIJU; SAKURAI SHIN; ISHIZUKA HIROYUKI; SAITO HIROYUKI; KOMATSU YUUKI; SASHO MANABU; SATO NOBUAKI; NEGI SHIGETO
权利人:EISAI CO LTD
摘要:A production process which comprises subjecting a basic antibiotic.oxalate (II) to salt-exchange with an alkali earth metal salt (III) of an inorganic acid:wherein the ring A means the basic antibiotic; R<10 >means a protected functional group used in organic synthesis; Ak-E means the alkali earth metal; and B means the inorganic acid, respectively.
网址: http://www.chemcollabrate.com
电话: 86-22-6330193963152679👤
销售电话:86-22-6330193963152679
邮箱：sales@chemcollaborate.com
电话: 86-22-6330193963152679👤
📞天津市科莱博瑞科技有限公司 ⚠️参考联系方式
销售电话:86-22-6330193963152679
邮箱：sales@chemcollaborate.com
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领，请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实，百琢研不参与任何交易。企业认领注册入口→
⚠️ 未注册 · 未认证企业
备注: 📌 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议， 请通过页面底部联系方式告知我们，我们会尽快处理。网址: http://www.sdpysh.com
电话: 0531-89702887/0531-88993893👤
销售电话:0531-89702887/0531-88993893
邮箱：sales@sdsihuanpharm.com
电话: 0531-89702887/0531-88993893👤
📞山东天铭医药集团有限公司 ⚠️参考联系方式
销售电话:0531-89702887/0531-88993893
邮箱：sales@sdsihuanpharm.com
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领，请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实，百琢研不参与任何交易。企业认领注册入口→
⚠️ 未注册 · 未认证企业
备注: 📌 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议， 请通过页面底部联系方式告知我们，我们会尽快处理。第 1 / 1 页
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Imada A, Hirai S. Cefotiam hexetil. Int J Antimicrob Agents. 1995 Apr;5(2):85-99. doi: 10.1016/0924-8579(94)00038-v. 44(3):481-4, 493. Chinese. 34(10):455-9. French. 12(3):211-5. doi: 10.1007/BF01967115. 39(1):33-6. doi: 10.1007/BF02657053. 42(7):980-2. 43(12):863-6. doi: 10.1111/j.2042-7158.1991.tb03196.x. 46(4):383-4. doi: 10.1007/BF00194411. 35(6):843-54. doi: 10.1093/jac/35.6.843. 44(5):481-93. Japanese.
合成参考文献
摘要:Gekkan Yakuji. Pharmaceuticals Monthly., 32(1770), 1990
📝 需求与反馈
尽可能描述清楚需求与问题信息
