CAS: 7477-63-6; 7-Cloroindoline-2,3-Dione

上下游产品

CAS号302-17-0 水合氯醛 | CAS号95-51-2 2-氯苯胺 | CAS号14722-82-8 (2E)-N-(2-chlor... | CAS号63497-60-9 3-氯靛红酸酐 | CAS号6388-47-2 2-氨基-3-氯苯甲酸 | CAS号101494-95-5 8-氯喹唑啉-4-醇 | CAS号125255-17-6 6-chloro-1,2-di... | CAS号74396-74-0 7-chloro-3-(hyd... | CAS号83393-71-9 2H-Indol-2-one,... | CAS号85511-68-8 VU0238441 | CAS号86915-16-4 7-氯-3-甲基-1H-吲哚 | CAS号90785-93-6 8-chloro-2-ethe... | CAS号99304-29-7 7-chloro-3-hydr...

N-(2-Chlorophenyl)-2-Isonitrosoacetanilide置于硫酸体系中,用34.5 %的收率获得产物7-氯靛红
参考文献:探索新型吲唑衍生物作为 Ask1 抑制剂:设计,合成,生物学评价和对接研究
标题:探索新型吲唑衍生物作为 Ask1 抑制剂:设计,合成,生物学评价和对接研究
摘要:凋亡信号调节激酶 1 (Ask1,Map3K5) 是丝裂原激活蛋白激酶 (Mapk) 信号通路的成员,参与细胞存活,分化,应激反应和凋亡. Ask1 激酶抑制已成为治疗非酒精性脂肪性肝炎 (Nash) 疾病的一种有前途的策略.设计并合成了一系列具有吲唑支架的新型ask1抑制剂,并评估了它们的ask1激酶活性.系统结构活性关系(sar)研究发现了一种有前途的化合物,它对ask1有很强的抑制作用.值得注意的观察结果包括油红 O 染色的 Lo2 细胞内脂滴明显减少,以及 Nash 模型细胞组内 Ldl,Cho 和 Tg 含量的减少.机制研究表明,该化合物可以抑制 Tnf-α 处理的 Hgc-27 细胞中上调的 Ask1-P38/jnk 信号通路的蛋白表达水平,并调节凋亡蛋白.总之,这些发现表明该化合物作为抗 Nash 的潜在候选化合物可能对进一步研究有价值.
DOI:10.1016/j.Bioorg.2024.107391

专利信息

专利号:US-12110273-B2
优先权日:2022-07-26
标题:Method of preparing indolin-2-one compound and method of using indolin-2-one
发明人：LUO MEI
权利人:UNIV HEFEI TECHNOLOGY
摘要:A compound, having a structure represented by a formula (I), n n n n n n n n n n and prepared by one-pot synthesis of benzophenone hydrazone, 7-chloroisatin, and copper(II) acetate monohydrate, and refluxing in 100 mL of anhydrous methanol solvent for 48 hrs. A method for preparing the compound includes: collecting and placing 0.0235 g of benzophenone hydrazone, 0.6914 g of 7-chloroisatin, and 0.6720 g of copper(II) acetate monohydrate complex in a 100.0 mL flask; adding 50 mL of anhydrous methanol as a solvent; stirring a resulting mixture at room temperature for 48 hrs; performing column chromatography separation, and elution with petroleum ether/dichloromethane in a volume ratio of 1:1, and collecting final component points and naturally volatilizing the final component points to obtain 7(E)-chloro-3-diphenylmethylindolin-2-one crystals. The compound is used as a catalyst for reaction between benzophenone imine and trimethylsilonitrile, and has a catalytic effect with a conversion rate reaching 99%.

专利号:US-8933248-B2
优先权日:2012-06-21
标 题:3-substituted-3-hydroxy oxindole derivatives and process for preparation thereof
发明人：RAO MANDAPATI MOHAN; PRATHIMA PARVATHANENI SAI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to expedient method for synthesis of 3-substituted-3-hydroxy-oxindole derivatives, which are useful as synthetic precursors to valuable pharmaceutical compounds. These are synthesized by reacting nitromethane with the corresponding isatins of formula (I). The reaction process of isatins was carried using water as a solvent at room temperature to form the corresponding 3-hydroxy-3-nitromethylindolin-2-ones of formula (II).

专利号:CN-111187233-B
优先权日:2020-01-18
标 题:A kind of multi-substituted benzothiazole and its derivatives and its synthesis method

专利号:CN-119504421-A
优先权日:2024-07-30
标 题:Synthesis and application of 2-fluorobenzamide sodium hydroxide complex