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参考文献: Rorγ Antagonist And Application Thereof In Medicine[fr] Antagoniste De Rorγ Et Son Utilisation En Médecine
标题: Rorγ Antagonist And Application Thereof In Medicine[fr] Antagoniste De Rorγ Et Son Utilisation En Médecine
摘要:本文提供的化合物为具有式(i)的rorγ拮抗剂.这些化合物或其药物组成物可用于调节视黄醇相关孤儿受体γ(rorγt).本文还提供了这些化合物及其组成物的制备方法,以及在治疗或预防哺乳动物,特别是人类中的rorγt介导的炎症或自身免疫疾病中的用途.

专利信息

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.