CAS: 58086-67-2; 2-Fluoro-1-Methylpyridin-1-Ium 4-Methylbenzenesulfonate

相似化合物

59387-91-6 7403-46-5 82228-89-5

上下游产品

CAS号372-48-5 2-氟吡啶 | CAS号80-48-8 对甲苯磺酸甲酯 | CAS号38585-62-5 4-羟甲基-5-甲基咪唑盐酸盐 | CAS号7403-46-5 2-氯-1-甲基吡啶对甲苯磺酸盐

📜2-氯-1-甲基吡啶对甲苯磺酸盐置于potassium Fluoride体系中,用 乙腈 作为反应溶剂,化学反应 1.0H,以90%的收率获得产物2-氟-1-甲基吡啶翁对甲苯磺酸盐
参考文献:Preparation Of Mono-/difluorinated Hydrocarbon Compounds
标题:Preparation Of Mono-/difluorinated Hydrocarbon Compounds
摘要:从醇或羰基化合物中制备单氟或二氟烃化合物,通过将其中一种与氟化试剂反应制备,可选地在碱的存在下,氟化剂包括具有以下公式(f)的吡啶反应物,其中r0是烷基或环烷基基团.

专利信息

专利号:US-10005807-B2
优先权日:2013-04-12
标题 :Synthesis of sialylated/fucosylated human milk oligosaccharides
发明人：CHASSAGNE PIERRE; KHANZHIN NIKOLAY; HEDEROS MARKUS JONDELIUS; CHAMPION ELISE; MATWIEJUK MARTIN; DEKANY GYULA
权利人:GLYCOM AS
摘要:An achemo-enzymatic synthesis of oligosaccharides of formula 1 is presented wherein R is selected from —OH, —N 3 and —OR 6 wherein R 6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, —(CH 2) n —NH 2 and —(CH 2) n —N 3 wherein integer n is to 10, preferably 2 or 3, R is selected from sialyl moiety, —SO 3 H and —CH(R)—COOH wherein R is selected from H, alkyl and benzyl, R 2 is selected from H and fucosyl, R 3 is selected from H and sialyl, R 4 is selected from H and fucosyl, provided that at least one of R 3 and R 4 is H, and A is a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

专利号:WO-2014167537-A1
优先权日:2013-04-12
标题:Synthesis of sialylated/fucosylated oligosaccharides
发明人：KHANZHIN NIKOLAY; CHASSAGNE PIERRE; HEDEROS MARKUS; CHAMPION ELISE; MATWIEJUK MARTIN; DEKANY GYULA
权利人:GLYCOM AS
摘要:This invention relates to a chemo-enzymatic synthesis of oligosaccharidesof formula 1 wherein R is selected from -OH, -N 3 and -OR 6 wherein R 6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, -(CH 2 ) n -NH 2 and -(CH 2 ) n -N 3 wherein integer n is to 10, preferably 2 or 3, R 1 is selected from sialyl moiety, -SO 3 H and -CH(R 5 )-COOH wherein R 5 is selected from H, alkyl and benzyl, R 2 is selected from H and fucosyl, R 3 is selected from H and sialyl, R 4 is selected from H and fucosyl, provided that one but only one of R 3 and R 4 is H, and A is selected from a bond and a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

专利号:US-6410643-B1
优先权日:2000-03-09
标题 :Solid phase synthesis method and reagent
发明人：SWANSON MELVIN J
权利人:SURMODICS INC
摘要:A reagent composition adapted to be coated onto a support surface in order to provide that surface with a high density of reactive groups. The surface, thus coated, can be used for any suitable purpose, and is particularly well suited for use as a solid phase synthesis support surface. The synthesis support surface, in turn, can be used in repetitive and combinatorial syntheses such as the synthesis of polynucleotides, polypeptides and polysaccharides. The polymeric coating can be used to provide increased effective surface area, particularly in situations in which the effective area of the support surface is itself limited, as on the surface of a silicon wafer. In so doing, the polymeric coating provides an optimal combination of such properties as reactive density and surface area or volume.

专利号:WO-2025132814-A1
优先权日:2023-12-21
标 题:Novel synthesis of methyl-2-fluoroacrylate
发明人：BRUNKE JESSICA; FISCHER MICHAEL; WÖSSNER JAN STEPHAN
权利人:VIFOR INT AG
摘要:The present invention relates to novel synthesis methods of methyl 2-fluoroacrylate (MFA) which is a key precursor for the production of Veltassa® (Patiromer). The methods according to the invention are conducted by reacting an α-substituted β-hydroxy propionic acid derivative (I) via one or more intermediate steps involving one or more α-, β-substituted propionic acid derivatives (II) to obtain MFA (III).

专利号:US-2014323705-A1
优先权日:2011-05-13
标题:Manufacture of lacto-n-tetraose
发明人：HEDEROS MARKUS; DEKANY GYULA; DEMKÓ Sà NDOR; Kovács Imre; BAJZA ISTVà N
权利人:HEDEROS MARKUS; DEKANY GYULA; DEMKÓ Sà NDOR; Kovács Imre; BAJZA ISTVà N
摘要:The present invention relates to the synthesis of the tetrasaccharide of formula (I) and novel intermediates used in the synthesis.

专利号:US-2014303363-A1
优先权日:2011-12-09
标题 :Preparation and Use of Isolactosamine and Intermediates therefor
发明人：HEDEROS MARKUS; RISINGER CHRISTIAN; BOUTET JULIEN; DEKANY GYULA
权利人:GLYCOM AS
摘要:The invention relates to providing isolactosamine (Galβ1-3GlcNH 2 , formula 1) and salts thereof in the form of either anomer or mixture thereof, as well as hydrates or solvates of the free base and salts thereof. The synthesis of isolactosamine and its use in the synthesis of lacto-N-biose containing oligosaccharides are also disclosed.