CAS: 4663-97-2; Pyridine-2,6-Dicarboxamide

该化合物是一种有机化合物,其特征为2和6个位置,用两组碳酸盐环替换成两组碳酸盐,该化合物一般是白色至白色固体,可溶于水和酒精等极地溶剂,因为存在可进行氢结合的薄膜机组,可溶于水和酒精等极地溶解物,呈现了氨化物的典型特性,包括中度熔融点和沸点,环的存在提供了与金属离子协调的基本性和潜力,使其具有协调化学的兴趣.此外,2,6-Pyridinedcardboxarmide可能展示生物活动,可以用于药物或农用化学用途,其结构特征允许在各种化学环境中发生潜在互动,使其成为合成有机化学的多种化合物.应参考安全数据处理,如处理任何化学物质,以确保采取适当的防范措施.

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CAS号504-29-0 2-氨基吡啶 | CAS号1122-58-3 4-二甲氨基吡啶 | CAS号5453-67-8 2,6-吡啶二甲酸二甲酯 | CAS号2893-33-6 2,6-吡啶二甲腈 | CAS号3739-94-4 2,6-吡啶二甲酰氯 | CAS号499-83-2 2,6-吡啶二羧酸 | CAS号15658-60-3 2,6-吡啶二羧酸二乙酯 | CAS号108-48-5 2,6-二甲基吡啶 | CAS号2893-33-6 2,6-吡啶二甲腈 | CAS号141-86-6 2,6-二氨基吡啶 | CAS号33354-88-0 2,6-二丙基吡啶 | CAS号138150-34-2 2,6-bis(4,5-dih... | CAS号84877-69-0 2-O,6-O-dimethy... | CAS号86309-74-2 3,6,9,12,15,18,... | CAS号53914-89-9 3,6,9,12,15-pen...

合成工艺路线路线简述

    📜吡啶-2.6-二羧酸二甲酯置于氨体系中,用 甲醇,水 作为反应溶剂,化学反应 24.0H,以67%的收率获得产物吡啶-2,6-二甲酰胺
    参考文献:双(ami胺肟)的合成及其作为铀酰络合剂的性能评估
    标题:双(ami胺肟)的合成及其作为铀酰络合剂的性能评估
    摘要:铀污染涉及高毒性和放射性,因此对人类健康和环境构成严重威胁.螯合是螯合铀的有效方法.众所周知,基于肟基的螯合剂能够有效地络合铀酰阳离子.为此,通过羟胺与相应的二腈反应合成了各种双(ami胺肟).在这些化合物中,A胺肟被各种长度的链隔开,有些长度包括杂环(吡啶或1,3,5-三嗪).通过等温滴定热量法(itc)测定它们的亲和常数和热力学参数,评估了这些双(ami胺肟)在水中复合铀酰阳离子的能力.还进行了dft计算,确定在铀酰阳离子和肟酸基团之间形成的配合物的最佳结构.在这项工作中也合成的四(ami胺肟)对铀显示出非常好的亲和力,并且一个分子能够螯合几个铀酰阳离子.这些结果对铀污染废水的修复具有重要意义,并为设计和合成新型a胺肟化合物开辟了一些前景.
    DOI:10.1016/j.Tet.2018.04.016

    海关参考信息

    专利信息


    专利号:US-6861531-B2
    优先权日:2002-03-27
    标 题:Synthesis of 2,6-dicarbonylpyridines
    发明人:GATELY DANIEL A
    权利人:BOULDER SCIENT CO
    摘要:Synthesis of 2,6-dicarbonylpyridines in solution in a hydrocarbon medium is described. The solutions of 2,6-dicarbonylpyridines may be used directly in further syntheses.

    专利号:US-2009111737-A1
    优先权日:1999-05-24
    标题:Novel antibacterial agents
    发明人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
    权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
    摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

    专利号:WO-2025006460-A9
    优先权日:2023-06-30
    标题:Systems and methods of sequencing polynucleotides with modified bases
    发明人:LU BO; WEI WEI; GOH HUI KHENG KAREN; VIECELI JOHN SILVIO; TEO YIN NAH
    权利人:ILLUMINA INC
    摘要:Described are DNA sequencing systems and methods. Systems and methods for determining the nucleotide sequence of a polynucleotide may include determining the sequence of a polynucleotide with more than four types of bases by increasing the number of encoding states in sequencing by synthesis (SBS) systems. The systems and methods may expand the encoding space of current systems by discretizing the amplitude space in a channel into more than two states, and/or by adding additional channels.

    专利号:US-2003187271-A1
    优先权日:2002-03-27
    标题 :Synthesis of 2, 6-dicarbonylpyridines

    专利号:WO-2025006466-A1
    优先权日:2023-06-30
    标 题:Systems and methods of sequencing polynucleotides with four labeled nucleotides
    发明人:KAGALWALLA ABDE ALI HUNAID; VIECELI JOHN SILVIO
    权利人:ILLUMINA INC
    摘要:The application relates to DNA sequencing systems and methods. Systems and methods for determining the nucleotide sequence of a polynucleotide may include introducing a fourth labeled nucleotide in a two-channel sequencing by synthesis system that allows for encoding space for a detecting a fifth labeled nucleotide or empty well detection.

    专利号:WO-2025006464-A1
    优先权日:2023-06-30
    标题 :Systems and methods of sequencing polynucleotides with alternative scatterplots
    发明人:CALLINGHAM MICHAEL JAMES; HONG STANLEY SEOKJONG; ANNETTE CALLUM MARK
    权利人:ILLUMINA INC
    摘要:The application relates to DNA sequencing systems and methods. Systems and methods for determining the nucleotide sequence of a polynucleotide may include introducing a fourth labelled nucleotide in a two-channel sequencing by synthesis system to create alternative X-Y scatterplot shapes where the x-axis represents the intensity of fluorescence at one wavelength (channel 1), and the y-axis represents intensity of fluorescence at another wavelength (channel 2 The alternative scatterplot shapes may allow for additional encoding space for empty well detection.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Aurélie Guenet, Et Al. Porphyrin-Based Switchable Molecular Turnstiles. Chemistry. 2011 May 27;17(23):6443-52.
    [参考文献]: Sung-Kyun Ko, Et Al. Synthetic Ion Transporters Can Induce Apoptosis By Facilitating Chloride Anion Transport Into Cells. Nat Chem. 2014 Oct;6(10):885-92.

    合成参考文献


    参考文献:10.4061/2011/184735
    摘要:Kaluzhny DN, Shchyolkina AK, Ilyinsky NS, Borisova OF, Shtil AA. Novel Indolocarbazole Derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione Is a Preferred c-MycGuanine Quadruplex Ligand. Journal of Nucleic Acids. 2011;2011():1–8. doi: 10.4061/2011/184735.
    参考文献:10.1007/s00018-011-0767-6
    摘要:Gauthier LR, Granotier C, Hoffschir F, Etienne O, Ayouaz A, Desmaze C, Mailliet P, Biard DS, Boussin FD. Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death. Cellular and Molecular Life Sciences. 2011 Jul 20;69(4):629–40. doi: 10.1007/s00018-011-0767-6.
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