专利号:US-6861531-B2 优先权日:2002-03-27 标 题:Synthesis of 2,6-dicarbonylpyridines 发明人:GATELY DANIEL A 权利人:BOULDER SCIENT CO 摘要:Synthesis of 2,6-dicarbonylpyridines in solution in a hydrocarbon medium is described. The solutions of 2,6-dicarbonylpyridines may be used directly in further syntheses.
专利号:US-2009111737-A1 优先权日:1999-05-24 标题:Novel antibacterial agents 发明人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES 权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES 摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.
专利号:WO-2025006460-A9 优先权日:2023-06-30 标题:Systems and methods of sequencing polynucleotides with modified bases 发明人:LU BO; WEI WEI; GOH HUI KHENG KAREN; VIECELI JOHN SILVIO; TEO YIN NAH 权利人:ILLUMINA INC 摘要:Described are DNA sequencing systems and methods. Systems and methods for determining the nucleotide sequence of a polynucleotide may include determining the sequence of a polynucleotide with more than four types of bases by increasing the number of encoding states in sequencing by synthesis (SBS) systems. The systems and methods may expand the encoding space of current systems by discretizing the amplitude space in a channel into more than two states, and/or by adding additional channels.
专利号:US-2003187271-A1 优先权日:2002-03-27 标题 :Synthesis of 2, 6-dicarbonylpyridines
专利号:WO-2025006466-A1 优先权日:2023-06-30 标 题:Systems and methods of sequencing polynucleotides with four labeled nucleotides 发明人:KAGALWALLA ABDE ALI HUNAID; VIECELI JOHN SILVIO 权利人:ILLUMINA INC 摘要:The application relates to DNA sequencing systems and methods. Systems and methods for determining the nucleotide sequence of a polynucleotide may include introducing a fourth labeled nucleotide in a two-channel sequencing by synthesis system that allows for encoding space for a detecting a fifth labeled nucleotide or empty well detection.
专利号:WO-2025006464-A1 优先权日:2023-06-30 标题 :Systems and methods of sequencing polynucleotides with alternative scatterplots 发明人:CALLINGHAM MICHAEL JAMES; HONG STANLEY SEOKJONG; ANNETTE CALLUM MARK 权利人:ILLUMINA INC 摘要:The application relates to DNA sequencing systems and methods. Systems and methods for determining the nucleotide sequence of a polynucleotide may include introducing a fourth labelled nucleotide in a two-channel sequencing by synthesis system to create alternative X-Y scatterplot shapes where the x-axis represents the intensity of fluorescence at one wavelength (channel 1), and the y-axis represents intensity of fluorescence at another wavelength (channel 2 The alternative scatterplot shapes may allow for additional encoding space for empty well detection.
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合成参考文献
参考文献:10.4061/2011/184735 摘要:Kaluzhny DN, Shchyolkina AK, Ilyinsky NS, Borisova OF, Shtil AA. Novel Indolocarbazole Derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione Is a Preferred c-MycGuanine Quadruplex Ligand. Journal of Nucleic Acids. 2011;2011():1–8. doi: 10.4061/2011/184735. 参考文献:10.1007/s00018-011-0767-6 摘要:Gauthier LR, Granotier C, Hoffschir F, Etienne O, Ayouaz A, Desmaze C, Mailliet P, Biard DS, Boussin FD. Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death. Cellular and Molecular Life Sciences. 2011 Jul 20;69(4):629–40. doi: 10.1007/s00018-011-0767-6.