专利号:US-5461169-A 优先权日:1992-06-23 标 题:Total synthesis of taxol and taxol analogs 发明人:NICOLAOU K C; YANG ZHEN; LIU JIN-JUN; UENO HIROAKI; NANTERMET PHILIPPE G 权利人:SCRIPPS RESEARCH INST 摘要:The total synthesis of taxol employs a convergent synthetic plan. The synthetic plan may also be employed to produce a large number of taxol analogs. Taxol analogs having skeletal extensions are inaccessible by modification of the natural product but are readily produced by employing the convergent synthetic plan herein.
专利号:US-2014011992-A1 优先权日:2012-12-20 标 题:Synthesis of abiraterone and related compounds 发明人:PEREZ ENCABO ALFONSO; TURIEL HERNANDEZ JOSE ANGEL; GALLO NIETO FRANCISCO JAVIER; LORENTE BONDE-LARSEN ANTONIO; SANDOVAL RODRIGUEZ CELSO MIGUEL 权利人:CRYSTAL PHARMA SAU 摘要:The present invention relates to processes for obtaining abiraterone and derivatives thereof, such as abiraterone acetate, by means of a Suzuki coupling through a steroid borate of general formula (IV) or a C—C coupling through a steroid hydrazone of general formula (II), as well as to intermediates useful in said processes.
专利号:US-2006009479-A1 优先权日:2004-07-09 标 题 :Process for the synthesis of hydromorphone 发明人:BAILEY TIMOTHY S; GEE PAUL S; REZAIE ROBERT 权利人:BAILEY TIMOTHY S; GEE PAUL S; REZAIE ROBERT 摘要:There is described a method for converting oripavine to hydromorphone or a physiologically acceptable salt thereof such as hydromorphone hydrochloride involving generation of 8,14-dihydrooripavine utilising diimine.
专利号:US-5760240-A 优先权日:1992-06-23 标题:Taxoid synthesis 发明人:NICOLAOU K C; CLAIBORNE CHRISTOPHER F; NANTERMET PHILIPPE G; COULADOUROS ELIAS A; SORENSON ERIK J 权利人:SCRIPPS RESEARCH INST 摘要:Bioactive ABC taxoids accessible by convergent synthesis have an intact AB ring framework of taxol, including the C13 side chain, and an aromatic C ring which substitutes for the CD ring system found on native taxol. The aromatic C ring may be substituted or unsubstituted. MPT derivatives of ABC taxoids are also disclosed.
专利号:US-5852005-A 优先权日:1994-07-27 标 题:Tetracyclic triterpenes 发明人:HIESTAND PETER; NAEF RETO; NAEGELI HANS-ULRICH; OBERER LUKAS; REVESZ LASZLO; ROTH HANS-JOERG 权利人:NOVARTIS AG 摘要:The present invention relates to 17 α-dammara compounds having immunosuppressant and antiinflammatory activity and which are useful as pharmaceuticals, particularly for use as immunosuppressant and antiinflammatory agents. Specific 17 α-dammara compounds are included per se, for example the compound of formula IC, i.e. 17 α-23-(E)-dammara-20, 23-dien-3β, 25-diol, which may be obtained from the flour of the shoots of the Palmyrah palm, Borassus flabellifer L. In addition, processes for the synthesis of this and other dammara compounds and intermediates thereof are described.
专利号:US-8304545-B2 优先权日:2007-01-18 标 题:Quinuclidine derivative useful in the preparation of mequitazine 发明人:MIOSKOWSKI CHARLES; GONNOT VANESSA; BAATI RACHID; NICOLAS MARC 权利人:MIOSKOWSKI CHARLES; GONNOT VANESSA; BAATI RACHID; NICOLAS MARC; PF MEDICAMENT 摘要:The invention relates to a 1-aza-bicyclo[2.2.2]oct-2-en-3-ylmethyl acetate of the formula (I), wherein said compound is useful as a synthesis intermediate for the production of mequitazine.