CAS: 29509-91-9; 4-Chloro-2,6-Diphenylpyrimidine

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苄脒盐酸盐置于sodium Hydroxide,五氯化磷,三氯氧磷体系中,用 乙醇 用作溶剂,化学反应 3.0H,反应生成4-氯-2,6-二苯基嘧啶
参考文献:2,4,6-Trisubstituted Pyrimidines As A New Class Of Selective Adenosine A1 Receptor Antagonists
标题:2,4,6-Trisubstituted Pyrimidines As A New Class Of Selective Adenosine A1 Receptor Antagonists
摘要:Adenosine Receptor Antagonists Usually Possess A Bi-Or Tricyclic Heteroaromatic Structure At Their Core With Varying Substitution Patterns To Achieve Selectivity And/or Greater Affinity. Taking Into Account Molecular Modeling Results From A Series Of Potent Adenosine A(1) Receptor Antagonists,A Pharmacophore Was Derived From Which We Show That A Monocyclic Core Can Be Equally Effective. To Achieve A Compound That May Act At The Gns We Propose Imposing A Restriction Related To Its Polar Surface Area (Psa). In Consequence,We Have Synthesized Two Novel Series Of Pyrimidines,Possessing Good Potency At The Adenosine A,Receptor And Desirable Psa Values. In Particular,Compound 30 (Luf 5735) Displays Excellent A,Affinity (K-I = 4 Nm) And Selectivity (Less Than Or Equal To50% Displacement Of 1 Mum Concentrations Of The Radioligand At The Other Three Adenosine Receptors) And Has A Psa Value Of 53 Angstrom2.
Doi:10.1021/jm049448R

专利信息

专利号:WO-2021129102-A1
优先权日:2019-12-27
标 题 :Heterocyclic compound, synthesis method therefor, organic electroluminescent device and electronic apparatus
发明人：WANG JINPING; XUE ZHEN; CHEN ZHIWEI
权利人:SHAANXI LIGHTE OPTOELECTRONICS MAT CO LTD
摘要:Disclosed are a heterocyclic compound, a synthesis method therefor, an organic electroluminescent device and an electronic apparatus. The heterocyclic compound has a chemical structural formula as shown in formula 1, wherein M is selected from the groups shown in formula 1-A. The compound can improve the properties of the organic electroluminescent device.