CAS: 28809-04-3; (R)-2-Amino-3-((2-(Pyridin-4-yl)Ethyl)Thio)Propanoic Acid
该化合物是一种氨酸衍生物,其特征为与L-cysteine的乙基侧链相连的丙烯酸环.该化合物的特征为硫醇(-SH),该物质具有典型的硅酸,有助于其反应和潜在的生物活动.会增强化合物与生物目标互动的能力,使其对药用化学和药理感兴趣.氨基组及其结构中的箱状酸组将它归类为氨基酸,使其能够参与丙二酸联结的形成.此外,该化合物可能具有抗氧化剂活动等特性,有助于其反应和潜在的生物化学活动.该化合物的溶解性和稳定性可能受到pH的影响,其他离子或分子在溶液中的存在也会受到影响.
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1078-38-2 924628-44-4 29567-83-7物理性质
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专利信息
专利号:US-12351573-B2
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; CHENG KAI FAN
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.
专利号:US-2023159450-A1
优先权日:2020-05-08
标 题 :Dimers for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; ALTITI AHMAD
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.
专利号:US-2020354404-A1
优先权日:2019-05-09
标 题 :Peptidomimetic agents, synthesis and uses thereof
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.
专利号:WO-2025128985-A1
优先权日:2023-12-14
标题 :Sulfoxide and sulfone derivatives of thiocarbazates as synthons for azapeptides synthesis and process of using same
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Provided for herein are sulfoxide and sulfone derivatives of thiocarbazates that have the formula (I): wherein A, R, R 1 , R 2 , and n are defined herein. The compounds may be used as synthons in the synthesis of azaeptides and other aza- amino acid conjugates.
专利号:US-11440881-B2
优先权日:2019-05-09
标题 :Thiosemicarbazates and uses thereof
发明人：AL-ABED YOUSEF; ALTITI AHMAD
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Thioesters, thiocarbamates, thiocarbazates, semithiocarbazates, peptides, aza-amino acid conjugates, and azapeptides; and a chemoselective and site-specific functionalization protocol of protected thiocarbazates and semithiocarbazates are described. The protocol features the use of Mitsunobu reaction to alkylate specifically the nitrogen atom close to the acylthiol moiety with alcohols to produce protected mono-substituted thiocarbazates that can be stored for months, activated under mild conditions at low temperature using halonium reagents and integrated orthogonally to make substituted semicarbazides that can be used, e.g., as synthons in synthesis of aza-amino acid conjugates, azapeptides and other peptidomimetics. Methods for preparing and using ureases, carbazides, semicarbazides, beta-peptides, azapeptides, and other peptidomimetics and azapeptide conjugates, and uses of ureases, carbazides, semicarbazides, beta-peptides, azapeptides in drug discovery, diagnosis, inhibition, prevention and treatment of diseases are also described.
专利号:US-2022372022-A1
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
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主要参考文献
参考标题: Thiosemicarbazates And Uses Thereof Thiosemicarbazates Et Leurs Utilisations摘要:Thioesters, Thiocarbamates, Thiocarbazates, Semithiocarbazates, Peptides, Aza-Amino Acid Conjugates, And Azapeptides; And A Chemoselective And Site-Specific Functionalization Protocol Of Protected Thiocarbazates And Semithiocarbazates Are Described. The Protocol Features The Use Of Mitsunobu Reaction To Alkylate Specifically The Nitrogen Atom Close To The Acylthiol Moiety With Alcohols To Produce Protected Mono-Substituted Thiocarbazates That Can Be Stored For Months, Activated Under Mild Conditions At Low Temperature Using Halonium Reagents And Integrated Orthogonally To Make Substituted Semicarbazides That Can Be Used, E.G., As Synthons In Synthesis Of Aza-Amino Acid Conjugates, Azapeptides And Other Peptidomimetics. Methods For Preparing And Using Ureases, Carbazides, Semicarbazides, Beta-Peptides, Azapeptides, And Other Peptidomimetics And Azapeptide Conjugates, And Uses Of Ureases, Carbazides, Semicarbazides, Beta-Peptides, Azapeptides In Drug Discovery, Diagnosis, Inhibition, Prevention And Treatment Of Diseases Are Also Described.
合成参考文献
参考文献:10.1016/0003-2697(84)90473-1
摘要:Fullmer CS. Identification of cysteine-containing peptides in protein digests by high-performance liquid chromatography. Anal Biochem. 1984 Nov 01;142(2):336–9. doi: 10.1016/0003-2697(84)90473-1.
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