CAS: 218632-01-0; 3-Fluoro-4-Nitrobenzonitrile

上下游产品

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3,4-二氟苯腈置于盐酸,Sodium Perborate Tetrahydrate,氨,溶剂黄146体系中,用 四氢呋喃,水 用作溶剂,20.0~110.0 °C,101.33 Kpa 条件下,反应 25.0H,反应生成3-氟-4-硝基苯腈
参考文献:一种3-氟-4-硝基苯甲酸的制备方法
标题:一种3-氟-4-硝基苯甲酸的制备方法
摘要:本发明涉及有机化学领域,特别是涉及一种3‑氟‑4‑硝基苯甲酸的制备方法,所述制备方法包括如下步骤:用3,4‑二氟苯腈作为原料,先与取代试剂反应制得4‑氨基‑3‑氟苯腈,然后将4‑氨基‑3‑氟苯腈与酸试剂反应转化为氨基盐后,再将氨基盐进行氧化反应,氨基盐进行氧化反应的反应快速且杂质少,最后经过氰基水解得到3‑氟‑4‑硝基苯甲酸,总收率可达到60%以上,且该制备方法的生产过程简洁,总收率高,生产安全性高,成本低,三废少.#imgabs0#

专利信息

专利号:WO-2023072966-A1
优先权日:2021-10-26
标题:Imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4
发明人：DEAU EMMANUEL; GEORGE PASCAL; MEIJER LAURENT; MIEGE FRÉDÉRIC
权利人:PERHA PHARMACEUTICALS
摘要:The present invention relates to a compound of formula (I) wherein R 1 represents a (C 4 -C 6) alkyl group, a (C 3 -C 8) cycloalkyl group, a bridged (C 6 -C 10 )cycloalkyl group, a fused phenyl group, a substituted phenyl group, a R'-L- group, wherein L is either a single bond or a (C 1 -C 3 )alkanediyl group, and R' represents, a (C 3 -C 8 )heterocycloalkyl group, or a (C 3 -C 8 )heteroaryl group, or a R''-L- group wherein L is a (C 1 -C 3 )alkanediyl group, and R'' is an optionally substituted phenyl group; R 2 is selected from the group consisting of a hydrogen atom and a (C 1 -C 3 )alkyl group; R 5 represents a hydrogen atom, a (C 1 -C 4 )alkyl group or a (C 3 -C 6 )cycloalkyl group or any of its pharmaceutically acceptable salt. The present invention further relates to a composition comprising a compound of formula (I) and a process for manufacturing said compound as well as its synthesis intermediates. It also relates to said compound for use as a medicament, in particular in the treatment and/or prevention of cognitive deficits and neuroinflammation associated with Down syndrome; Alzheimer's disease; dementia; tauopathies; Parkinson's disease; CDKL5 Deficiency Disorder; Phelan-McDermid syndrome; autism; type 1 and type 2 diabetes; abnormal folate and methionine metabolism; osteoarthritis and tendinopathy; Duchenne muscular dystrophy; cancers and leukemias; neuroinflammation, anemia, infections caused by unicellular parasites, viral infections and for regulating body temperature.