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专利信息

专利号:US-8652442-B2
优先权日:2008-11-03
标题 :Bioluminescence imaging of myeloperoxidase activity in vivo, methods, compositions and apparatuses therefor
发明人：PIWNICA-WORMS DAVID; GROSS SHIMON; SHARMA VIJAY; GAMMON SETH
权利人:PIWNICA-WORMS DAVID; GROSS SHIMON; SHARMA VIJAY; GAMMON SETH; UNIV WASHINGTON
摘要:Methods of imaging distribution of myeloperoxidase activity in a subject are disclosed. These methods include the use of bioluminescent substrates, including luminol and wavelength-shifted analogues of luminol. Bioluminescent myeloperoxidase substrates that emit light at longer wavelengths compared to luminol are shown to be useful for imaging myeloperoxidase activity in vivo. The disclosed methods can be used for imaging sites of inflammation and other pathological conditions associated with abnormal levels of MPO activity in vivo. Methods of synthesis of luminol analogues are also disclosed.

专利号:CN-120040355-A
优先权日:2025-02-12
标 题 :A synthesis process and application of luminol monosodium salt precursor for chemiluminescent substrate liquid