CAS: 19902-08-0; (1R,5R)-6,6-Dimethyl-4-Methylidenebicyclo[3.1.1]Heptane

该化合物是一种天然的皮内异构体,主要来源于树和基本油,它具有很高的纯度和稳定性,适合用于香味,口味和合成化学的前体,其性能结构适合特定的声音反应,特别是在合成精美化学品和药物方面. (+)-β-皮内还研究其潜在的生物活动,包括抗微生物和抗炎特性,它与普通溶剂和试剂的低再活性确保了工业和实验室环境中的连续性能.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

(-)-α-pinene (1'R,2'S,5'S)-2-(2'-Hydroxy-6',6'-dimethylbicyclo[3.1.1]hept-2'-yl)acetic acid (1R)-(-)-nopol geranyl diphosphate R)-((1R)-pin-2-en-10-yl)-succinic acid-anhydride(R)-((1R)-pin-2-en-10-yl)-succinic acid-anhydride (4S)-1-(2,2,2-trichloroethyl)-4-(2-chloroisopropyl)cyclohex-1-ene endo-borneol (1R)-(-)-nopol

合成工艺路线路线简述

    海关参考信息

    专利信息


    专利号:US-4140708-A
    优先权日:1975-10-16
    标 题 :Asymmetric synthesis of optically active prostaglandins
    发明人:CHADHA NARESH K; PARTRIDGE JR JOHN J; USKOKOVIC MILAN R
    权利人:HOFFMANN LA ROCHE
    摘要:An asymmetric synthesis of optically active prostaglandin F 2 α from cyclopentadiene including intermediates in this synthesis.

    专利号:US-3933892-A
    优先权日:1973-02-12
    标题 :Asymmetric synthesis of optically active prostaglandins
    发明人:CHADHA NARESH KUMAR; PARTRIDGE JR JOHN JOSEPH; USKOKOVIC MILAN RADOJE
    权利人:HOFFMANN LA ROCHE
    摘要:An asymmetric synthesis of optically active prostaglandin F 2 .sub.α from cyclopentadiene including intermediates in this synthesis.

    专利号:US-10435344-B2
    优先权日:2015-12-10
    标题 :Reaction sequence for the synthesis of nootkatone, dihydronootkatone, and tetrahydronootkatone
    发明人:LAINE ROGER
    权利人:LAINE ROGER; UNIV LOUISIANA STATE
    摘要:An inexpensive, stereoselective synthesis for nootkatone, tetrahydronootkatone, and their derivatives is disclosed utilizing ozonolysis. The starting materials used in the synthesis are inexpensive and the reactions are commercially feasible and amenable to scaling up. The principal starting material, (−)-β-Pinene, is on the GRAS list (generally recognized as safe).

    专利号:US-7112700-B1
    优先权日:2005-04-14
    标 题 :Efficient and economic asymmetric synthesis of nootkatone, tetrahydronootkatone, their precursors and derivatives
    发明人:SAUER ANNE M; CROWE WILLIAM E; LAINE ROGER A; HENDERSON GREGG
    权利人:UNIV LOUISIANA STATE
    摘要:An inexpensive, stereoselective synthesis for nootkatone, tetrahydronootkatone, and their derivatives is disclosed. The starting materials used in the synthesis are inexpensive. The principal starting material, (−)-β-Pinene, is on the GRAS list (generally recognized as safe).

    专利号:US-11078178-B2
    优先权日:2017-09-04
    标 题 :6-chromanol derivatives and their synthesis
    发明人:BEUMER RAPHAEL; BONRATH WERNER; DELPHO JAN-MARC; JORAY MARCEL; MEDLOCK JONATHAN ALAN; NETSCHER THOMAS; SORIANO DOMENICO; STEMMLER RENÉ TOBIAS
    权利人:DSM IP ASSETS BV
    摘要:The present invention relates to novel compounds which are particularly useful for the synthesis of novel chromanol derivatives. These compounds have interesting properties. Particularly, the novel chromanol derivatives have interesting antioxidant properties as well as flavours and fragrances.

    专利号:US-3579568-A
    优先权日:1965-08-18
    标题 :Synthesis of carboxylic acids from ethylene and carbon monoxide and noble metal compounds
    发明人:HECK RICHARD F; HENRY PATRICK M
    权利人:HERCULES POWDER CO
    摘要:THE DISCLOSED PROCESS IS A METHOD FOR PRODUCING CARBOXYLIC ACIDS BY CARBNYLATION OF OLEFINIC HYDROCARBONS. AN OLEFIN SUCH AS ETHYLENE, AND WATER OR AN ACID SUCH AS ACETIC ACID, ARE BROUGHT INTO CONTACT WITH CARBON MONOXIDE IN THE PRESENCE OF A COMPOUND OF A GROUP VIII NOBLE METAL SUCH AS PALLADIUM AT A TEMPERATURE IN THE RANGE OF 25* TO 250*C. USING ETHYLENE AND ACETIC ACID AS REACTANTS, THE PRODUCT CONTAINS B-ACETOXYPROPIONIC ACID. A REDOX AGENT SUCH AS CUPRIC CHLORIDE MAY BE USED TO EFFECT REGENERATION OF THE NOBEL METAL COMPOUND.

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    品牌试剂参考报价(招募中)

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Yus, M.; Foubelo, F., Science of Synthesis, (2010) 47, 1072.
    摘要:Li, Y.; Xie, W.; Jiang, X., Science of Synthesis Knowledge Updates, (2016) 2, 42.
    摘要:Landais, Y., Science of Synthesis Knowledge Updates, (2013) 3, 88.
    摘要:Chen, P.; Liu, G., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 196.
    参考文献:10.1023/b:joec.0000030269.07833.8f
    摘要:Hwang JY, Kim JH, Yun KW. The Effect of Selected Monoterpenoids on the Cellular Slime Mold, Dictyostelium discoideum NC4. Journal of Chemical Ecology. 2004 Jun;30(6):1153–63. doi: 10.1023/b:joec.0000030269.07833.8f.
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