CAS: 189278-27-1; 2-Bromo-6-(Trifluoromethyl)Pyridine

相似化合物

872365-91-8 1159512-38-5 1211539-45-5

上下游产品

CAS号81290-20-2 (三氟甲基)三甲基硅烷 | CAS号234111-08-1 2-溴-6-碘吡啶 | CAS号131747-42-7 6-(三氟甲基)吡啶甲酸 | CAS号131747-53-0 (6-三氟甲基-吡啶-2-基)-甲醇 | CAS号944904-58-9 1-(6-三氟甲基-吡啶-2-基)乙酮

6-(三氟甲基)吡啶-2-甲酸置于tetrakis(Acetonitrile)Copper(I)Tetrafluoroborate,1,3-二溴-5,5-二甲基海因,1-Fluoro-2,4,6-Trimethylpyridin-1-Ium Tetrafluoroborate体系中,用 乙腈 用作溶剂,化学反应 6.0H,以71%的收率获得2-溴-6-三氟甲基吡啶
参考文献:(杂)芳基羧酸脱羧卤化的统一方法
标题:(杂)芳基羧酸脱羧卤化的统一方法
摘要:芳基卤化物是合成化学中的基本基序,在金属介导的交叉偶联反应中起着关键作用,并在药物发现中充当重要的支架.尽管芳基羧酸的热脱羧官能化已得到广泛探索,但现有的卤代脱羧方法的范围仍然有限,并且目前不存在提供从芳基羧酸前体获得任何类型的芳基卤化物的统一策略.在此,我们报告了一种通过配体到金属电荷转移对(杂)芳基羧酸进行直接脱羧卤化的通用催化方法.该策略适用于极其广泛的底物范围.我们利用芳基自由基中间体实现不同的功能化途径:(1) 原子转移以获取溴代或碘代(杂)芳烃或(2)自由基被铜捕获并随后还原消除以生成氯代或氟代(杂)芳烃.所提出的配体到金属的电荷转移机制得到了一系列光谱研究的支持.
Doi:10.1021/jacs.2C02392

专利信息

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-2009275616-A1
优先权日:2008-04-30
标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues

专利号:WO-2023134686-A1
优先权日:2022-01-11
标题:Preparation method for 1,3,5-triazine derivative
发明人：HUANG TICONG; WU XIAOLEI; WANG SHANG; ZANG HAISHAN; QIN ZHIDONG; ZHANG HONGYING; CAI YAO; ZHAO RUI; LIU FEI
权利人:CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD
摘要:The present invention relates to the field of drug synthesis, particularly, to a preparation method for a 1,3,5-triazine derivative, more particularly, to a preparation method for 4-(tert-butoxyamino)-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazine-2-amine. The preparation method has the advantages of short route, simple operation, and high yield, and is more suitable for use in industrial production.

专利号:CN-116621794-A
优先权日:2023-05-22
标题:A kind of 5-benzyl-2-amino-1,3-thiazole derivatives and its synthesis method and application