专利号:US-6350739-B1 优先权日:1999-08-11 标 题:Methods of prevention and treatment of ischemic damage 发明人:SIMPKINS JAMES W; COVEY DOUGLAS F 权利人:UNIV FLORIDA RESARCH FOUNDATIO; UNIV WASHINGTON 摘要:The present invention in various embodiments provides methods of treating stroke and conferring protection on a population of cells associated with ischemia in a subject following an ischemic event, comprising: (a) providing an estrogen compound; and (b) administering the effective amount of the compound over a course that includes at least one dose within a time that is effectively proximate to the ischemic event, so as to confer protection on the population of cells. Novel methods are provided for the delivery of an estrogen compound. Examples of ischemic events treatable according to the invention are cerebrovascular disease or stroke, subarachnoid subhemorrhage, myocardial infarct, surgery and trauma. A method of treating ischemic damage utilizing hormones that are non-sex hormones is also provided. A method of treating stroke with ent-17β-estradiol, and a method of synthesis, and compounds produced from the synthesis are provided.
专利号:US-6150403-A 优先权日:1997-10-14 标 题 :Topical compositions for regulating the oily/shiny appearance of skin 发明人:BIEDERMANN KIMBERLY A; SCHUBERT HARRY L; PARRAN JR JOHN J 权利人:PROCTER & GAMBLE 摘要:The present invention relates to methods for inhibiting sebaceous gland activity in mammalian skin comprising administration of a topical composition comprising dehydroacetic acid or pharmaceutically acceptable salts thereof, and a dermatologically-acceptable carrier. The present invention also relates to methods and topical compositions further comprising agents which regulate the oily and/or shiny appearance of skin, and agents which treat acne and related skin disorders in mammalian skin and scalp. Methods of reducing sebum synthesis with the use of dehydroacetic acid, methods of regulating the oily and/or shiny appearance of skin, and methods of treating acne and other skin disorders are also encompassed by the present invention.
专利号:US-5902603-A 优先权日:1995-09-14 标题 :Polyurethane hydrogel drug reservoirs for use in transdermal drug delivery systems, and associated methods of manufacture and use 发明人:CHEN TUNG-FEN; CHIANG CHIA-MING; JONA JANAN; JOSHI PRITI; RAMDAS ASHA 权利人:CYGNUS THERAPEUTIC SYSTEMS 摘要:High capacity drug reservoirs are provided for incorporation into transdermal drug delivery systems. The drug reservoirs are hydrogels formulated from polyurethanes crosslinked with diisocyanate crosslinking agents or cured with radiation in the presence of a photoinitator. Drug loading as high as 65 to 70 wt. % or higher can be achieved by absorbing drug formulation into the reservoir after hydrogel synthesis. Methods for making and using transdermal systems containing such reservoirs are provided as well.
专利号:US-4537722-A 优先权日:1983-05-30 标 题:Steroid esters preparation 发明人:STAMVIK ANDERS R; KRISTENSSON STEN K; LUNDVALL KARL-ERIK 权利人:LEO AB 摘要:This invention relates to an improved steroid ester synthesis in which carbodiimides and catalytic amounts of 4-(tertiary amino)-pyridines, in combination with acid catalysts, are used as condensing agents, resulting in pure, non discolored compounds in high yields.
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198 参考文献:10.1016/j.scitotenv.2014.05.008 摘要:Pessoa GP, de Souza NC, Vidal CB, Alves JA, Firmino PI, Nascimento RF, dos Santos AB. Occurrence and removal of estrogens in Brazilian wastewater treatment plants. Sci Total Environ. 2014 Aug 15;490():288–95. doi: 10.1016/j.scitotenv.2014.05.008.