CAS: 1743-60-8; (8R,9S,13S,14S,17S)-3-Hydroxy-13-Methyl-7,8,9,11,12,13,14,15,16,17-Decahydro-6H-Cyclopenta[a]Phenanthren-17-Yl Acetate

该化合物是Astradiol的合成衍生物,是一种自然形成的雌激素,其特点是化学配方,包括一种在17个碳位置的乙酸性结构,这种改变增强了其脂质,允许在施用时改进吸收和生物利用率.Estradidol 17-Aletate因其强大的雌性致癌活动,通常用于激素替代疗法和避孕配方.它在调节各种生理过程方面发挥着关键作用,包括月经周期和生殖功能.该物质通常通过肌肉内注射或转基因修补来施用,以提供受控的激素释放.在安全方面,与其他雌激素一样,它可能会产生副作用和反作用,特别是在具有荷尔蒙敏感性史的个人中.其药理学和药理动力学研究得到很好研究,因此在与内分泌和生殖健康有关的临床和研究环境中都是一种重要的复合物.

结构式图片

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

CAS号2394-16-3 Estra-1,3,5(10)... | CAS号50-28-2 雌二醇 | CAS号141-78-6 乙酸乙酯 | CAS号1425-10-1 19-去甲睾酮乙酸盐 | CAS号108-24-7 乙酸酐 | CAS号23880-55-9 17β-Acetoxy-3-b... | CAS号14982-15-1 3-O-Benzyl Estradiol | CAS号53-16-7 雌酚酮 | CAS号88378-62-5 Estra-1,3,5(10)... | CAS号144082-87-1 [(8R,9S,13S,14S... | CAS号50-28-2 雌二醇 | CAS号5976-61-4 4-羟基雌二醇 | CAS号15270-30-1 17β-雌二醇 3β-D-葡糖苷酸

合成工艺路线路线简述

    📜雌酚酮置于platinum(Iv) Oxide 盐酸,Sodium Hydroxide,氢碘酸,氢气体系中,用 乙醇 用作溶剂,化学反应生成17Beta-雌二醇 17-乙酸酯
    参考文献:17β-Oestradiol 17-Methyl Ether
    标题:17β-Oestradiol 17-Methyl Ether
    摘要:
    Doi:10.1016/0039-128X(65)90103-0

    海关参考信息

    专利信息


    专利号:US-6350739-B1
    优先权日:1999-08-11
    标 题:Methods of prevention and treatment of ischemic damage
    发明人:SIMPKINS JAMES W; COVEY DOUGLAS F
    权利人:UNIV FLORIDA RESARCH FOUNDATIO; UNIV WASHINGTON
    摘要:The present invention in various embodiments provides methods of treating stroke and conferring protection on a population of cells associated with ischemia in a subject following an ischemic event, comprising: (a) providing an estrogen compound; and (b) administering the effective amount of the compound over a course that includes at least one dose within a time that is effectively proximate to the ischemic event, so as to confer protection on the population of cells. Novel methods are provided for the delivery of an estrogen compound. Examples of ischemic events treatable according to the invention are cerebrovascular disease or stroke, subarachnoid subhemorrhage, myocardial infarct, surgery and trauma. A method of treating ischemic damage utilizing hormones that are non-sex hormones is also provided. A method of treating stroke with ent-17β-estradiol, and a method of synthesis, and compounds produced from the synthesis are provided.

    专利号:US-6150403-A
    优先权日:1997-10-14
    标 题 :Topical compositions for regulating the oily/shiny appearance of skin
    发明人:BIEDERMANN KIMBERLY A; SCHUBERT HARRY L; PARRAN JR JOHN J
    权利人:PROCTER & GAMBLE
    摘要:The present invention relates to methods for inhibiting sebaceous gland activity in mammalian skin comprising administration of a topical composition comprising dehydroacetic acid or pharmaceutically acceptable salts thereof, and a dermatologically-acceptable carrier. The present invention also relates to methods and topical compositions further comprising agents which regulate the oily and/or shiny appearance of skin, and agents which treat acne and related skin disorders in mammalian skin and scalp. Methods of reducing sebum synthesis with the use of dehydroacetic acid, methods of regulating the oily and/or shiny appearance of skin, and methods of treating acne and other skin disorders are also encompassed by the present invention.

    专利号:US-5902603-A
    优先权日:1995-09-14
    标题 :Polyurethane hydrogel drug reservoirs for use in transdermal drug delivery systems, and associated methods of manufacture and use
    发明人:CHEN TUNG-FEN; CHIANG CHIA-MING; JONA JANAN; JOSHI PRITI; RAMDAS ASHA
    权利人:CYGNUS THERAPEUTIC SYSTEMS
    摘要:High capacity drug reservoirs are provided for incorporation into transdermal drug delivery systems. The drug reservoirs are hydrogels formulated from polyurethanes crosslinked with diisocyanate crosslinking agents or cured with radiation in the presence of a photoinitator. Drug loading as high as 65 to 70 wt. % or higher can be achieved by absorbing drug formulation into the reservoir after hydrogel synthesis. Methods for making and using transdermal systems containing such reservoirs are provided as well.

    专利号:US-4537722-A
    优先权日:1983-05-30
    标 题:Steroid esters preparation
    发明人:STAMVIK ANDERS R; KRISTENSSON STEN K; LUNDVALL KARL-ERIK
    权利人:LEO AB
    摘要:This invention relates to an improved steroid ester synthesis in which carbodiimides and catalytic amounts of 4-(tertiary amino)-pyridines, in combination with acid catalysts, are used as condensing agents, resulting in pure, non discolored compounds in high yields.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
    参考文献:10.1016/j.scitotenv.2014.05.008
    摘要:Pessoa GP, de Souza NC, Vidal CB, Alves JA, Firmino PI, Nascimento RF, dos Santos AB. Occurrence and removal of estrogens in Brazilian wastewater treatment plants. Sci Total Environ. 2014 Aug 15;490():288–95. doi: 10.1016/j.scitotenv.2014.05.008.
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