CAS: 159989-65-8; (3S,4As,8As)-N-(Tert-Butyl)-2-((2R,3R)-2-Hydroxy-3-(3-Hydroxy-2-Methylbenzamido)-4-(Phenylthio)Butyl)Decahydroisoquinoline-3-Carboxamide Methanesulfonate

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CAS号75-75-2 甲基磺酸 | CAS号159989-64-7 奈非那韦 | CAS号67000-01-5 ethyl-isopropyl...

📜(2R,3R)-4-((3S,4As,8As)-3-(Tertbutylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-Hydroxy-1-(Phenylthio)Butan-2-Aminium Benzoate 以 甲醇,二氯甲烷 用作溶剂,化学反应生成甲磺酸奈非那韦
参考文献:Optimization Of An Electrolyte System For The Simultaneous Separation Of Nelfinavir Mesylate And Two Impurities By Micellar Electrokinetic Chromatography
标题:Optimization Of An Electrolyte System For The Simultaneous Separation Of Nelfinavir Mesylate And Two Impurities By Micellar Electrokinetic Chromatography
摘要:A Methodology For The Simultaneous Determination Of Nelfinavir Mesylate And The Impurities 3-Hydroxy-2-Methylbenzoic Acid And (2R,3R)-4-((3S,4As,8As)-3-(Tert-Butylcarbamoyl) octahydroisoquinolin-2(1H)-yl)-3-Hydroxy-1-(Phenylthio)Butan-2-Aminium Benzoate By Micellar Electrokinetic Chromatography,With An Analysis Time Of 25 Min,Was Proposed. An Electrolyte Composed Of Sodium Tetraborate Buffer (Ph 9.24; 25 Mmol L-1),Sodium Dodecyl Sulphate (9 Mmol L-1) And Methanol (10%,V/v) Was Optimized Using A Mixed-Level Factorial Design,With Direct Detection At 200 Nm. After Evaluating Some Figures Of Merit,Such As Selectivity,Linearity,Precision,Limit Of Detection,Limit Of Quantification,Accuracy And Robustness (Using Youden'S Test),The Method Was Successfully Applied To The Analysis Of Nelfinavir Mesylate And Its Impurities In A Pharmaceutical Formulation. The Optimized Methodology Is Demonstrated To Be Useful In The Determination Of These Analytes In A Synthesis Monitoring Process,In Raw Materials And In Pharmaceutical Formulations,While Offering Low Solvent Consumption,Requiring A Small Sample And Using Non-Specific Columns As Advantages.
Doi:10.5935/0103-5053.20150049

专利信息

专利号:US-7173059-B2
优先权日:2003-05-08
标题:Intermediates useful in the synthesis of HIV-protease inhibitors and methods for preparing the same
发明人：ALBIZATI KIM FRANCIS; BABU SRINIVASAN
权利人:AGOURON PHARMA
摘要:Optically active 3-amino-butene and 1,2-dihydroxy-3-amino-butane intermediate compounds, useful in the synthesis of HIV-protease inhibitors and methods of preparing these intermediate compounds are disclosed.

专利号:US-6472534-B2
优先权日:1999-10-21
标 题:Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors
发明人：BORER BENNETT C; ZOOK SCOTT E; BUSSE JULIETTE K
权利人:AGOURON PHARMA
摘要:Methods for the preparation of chemical intermediates in the synthesis of HIV-protease inhibitors related to and including nelfinavir mesylate are disclosed. The method of this invention comprises converting tetrohydran derivatives into oxazolines to provide key reaction intermediates for the preparation of nelfinavir. Also disclosed is a method for the preparation of a chiral amino alcohol from an epoxy-tetrahydrofuran.

专利号:US-8987493-B2
优先权日:2010-05-20
标题 :Process for synthesis of silane dipeptide analogs
发明人：SIEBURTH SCOTT MCNEILL; BO YINGJIAN
权利人:SIEBURTH SCOTT MCNEILL; BO YINGJIAN; Temple University—Of the Commonwealth System of Higher Education
摘要:The invention provides a method of preparing silane dipeptide analogs, comprising the steps of treating a solution of a substituted 1,2-oxasilolane with lithium metal to form a solution of the dilithium salt of a substituted 3-hydroxypropylsilanol, and reacting the solution of the dilithium salt of the substituted 3-hydroxypropylsilanol with a substituted enamine.

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:US-11845970-B2
优先权日:2016-01-15
标 题:Endo-S2 mutants as glycosynthases, method of making and use for glycoengineering of glycoproteins
发明人：WANG LAI-XI; YANG QIANG; LI TIEZHENG; TONG XIN
权利人:UNIV MARYLAND
摘要:The present invention provides for recombinant Endo-S2 mutants (named Endo-S2 glycosynthases) that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sugar chain is added to a fucosylated or nonfucosylated GlcNAc-IgG acceptor. As such, the present invention allows for the synthesis and remodeling of therapeutic antibodies thereby providing for certain biological activities, such as, prolonged half-life time in vivo, less immunogenicity, enhanced in vivo activity, increased targeting ability, and/or ability to deliver a therapeutic agent.

专利号:US-8557979-B2
优先权日:2004-06-10
标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
发明人：CHOI WOO-BAEG; KOWALIK EWA
权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.