CAS: 147739-88-6; 6,7-Dihydro-5H-Pyrrolo[3,4-B]Pyridine

相似化合物

147740-02-1 651558-51-9 204593-51-1

上下游产品

CAS号109966-30-5 6-苄基-6,7-二氢-5H-... | CAS号45754-12-9 2,3-双(氯甲基)吡啶 | CAS号89-00-9 吡啶-2,3-二羧酸 | CAS号605-38-9 2,3-吡啶二甲酸二甲酯 | CAS号423169-40-8 2,3-吡啶二甲醇盐酸盐 | CAS号1059172-92-7 5H-吡咯并[3,4-b]吡啶... | CAS号186203-81-6 6-B°C-八氢吡咯并[3,4-b]吡啶 | CAS号1141669-88-6 6-乙基八氢吡咯并[3,4-B]吡啶

📜2,3-双(氯甲基)吡啶置于邻,对甲苯磺酰胺,Sodium Hydride体系中,用 N,N-二甲基甲酰胺 用作溶剂,以46%的收率获得6,7-二氢-5H-吡咯并[3,4-B]吡啶
参考文献:A Robust Process For An Mglur5 Negative Allosteric Modulator: Difluoromethylation And Sonogashira Coupling On Large Scale
标题:A Robust Process For An Mglur5 Negative Allosteric Modulator: Difluoromethylation And Sonogashira Coupling On Large Scale
摘要:The Development Of The Potent And Selective Mglur5 Negative Allosteric Modulator (Nam) 1 Is Described. Key Features In The Process,Which Has Been Implemented On A Multikilogram Scale,Include A High-Temperature Difluoromethylation Reaction,A Sonogashira Coupling,And Careful Control Of Residual Pd And Cu In The Final Api. Due To The Relative Nonpolar Nature Of The Intermediates,Water-Miscible Solvents Were Employed In All Four Steps To Allow For Direct Crystallizations Upon Reaction Completion. In Addition,Several Crystalline Morphologies Of The Api Were Discovered,And The Isolation Of The Desired Form Ii Will Be Discussed.
Doi:10.1021/op3002728

专利信息

专利号:US-12336981-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; DRAGOVICH Peter; GOSSELIN FRANCIS; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; ROTH BRUCE; SMITH CHASE C; WANG ZHONGGUO; YUEN PO-WAI; ZHENG XIAOZHANG
权利人:VALO HEALTH INC; GENENTECH INC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:US-9169209-B2
优先权日:2011-05-04
标题:Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BAUMEISTER TIMM; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and composition for inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.

专利号:US-11312722-B2
优先权日:2019-05-08
标 题:Hsp90 inhibitors and uses thereof
发明人：BROWN LAUREN ELAINE; HUANG DAVID S; COWEN LEAH E; WHITESELL LUKE; MARCYK PAUL
权利人:UNIV BOSTON; GOVERNING COUNCIL UNIV TORONTO
摘要:Herein is described the design and synthesis of resorcylate aminopyrazole compounds. These compounds show broad, potent and fungal-selective Hsp90 inhibitory activity. These compounds also find use in treating Hsp90 related diseases.

专利号:US-8536164-B2
优先权日:2010-12-20
标 题:Fused pyridine compounds as casein kinase inhibitors
发明人：BUTLER TODD W; CHANDRASEKARAN RAMALAKSHMI Y; MENTE SCOT R; SUBRAMANYAM CHAKRAPANI; WAGER TRAVIS T
权利人:BUTLER TODD W; CHANDRASEKARAN RAMALAKSHMI Y; MENTE SCOT R; SUBRAMANYAM CHAKRAPANI; WAGER TRAVIS T; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: n nand pharmaceutically acceptable salts thereof, wherein X, Y, A, R 4 , n, and R 7 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.