专利号:US-2012094919-A1 优先权日:2009-03-16 标题 :Use of tripeptides 发明人:GRAEUB REMO; HEIDL MARC; IMFELD DOMINIK; MUELLER EIKE; WIKSTROEM PETER; ZIEGLER HUGO 权利人:GRAEUB REMO; HEIDL MARC; IMFELD DOMINIK; MUELLER EIKE; WIKSTROEM PETER; ZIEGLER HUGO 摘要:The present invention relates to the use of tripeptide derivatives for tightening, firming and/or moisturizing skin. Furthermore, the invention relates to a method for stimulating the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue and/or proteoglycans by fibroblasts and/or keratinocytes such as in particular the synthesis of Hyaluronic acid and/or of the proteoglycans Decorin and/or Lumican.
专利号:US-8138272-B2 优先权日:2006-05-22 标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds 发明人:KONRADI ANDREI W; SMITH JENIFER L 权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC 摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.
专利号:US-2009285888-A1 优先权日:2005-05-13 标题:Derivatives of dihydroxyphenylalanine 发明人:SUSILO GISELA 权利人:SUSILO GISELA 摘要:The invention relates to derivatives of dihydroxyphenylalanine, to their synthesis and to pharmaceutical compositions containing said derivatives of dihydroxyphenylalanine. Furthermore, the invention relates to the use of said derivatives of dihydroxyphenylalanine and said pharmaceutical compositions for the treatment and prophylaxis of movement disorders, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, hemiparkinson-hemiatrophy, parkinsonian syndrome, Lewy body disease, frontotemporal dementia, Lytico-Bodig disease (parkinsonism/dementia/amyotrophic lateral sclerosis), striatonigral degeneration, Shy-Drager syndrome, sporadic olivopontocerebellar degeneration, progressive atrophy of the globus pallidus, progressive supranuclear palsy, Hallervorden-Spatz disease, Huntington's disease, X-linked dystonia-parkinsonism (Lubag), mitochondrial cytopathy with striatal necrosis, neuroacanthocytosis, restless legs syndrome, Wilson's disease.
专利号:US-2007243147-A1 优先权日:2004-07-24 标 题:Skin and/or Hair Composition Containing Compounds for Increasing The Tanning of Skin 发明人:WOLBER RAINER; TOM DIECK KAREN; SCHERNER CATHRIN; SCHLENZ KATHRIN; KRUSE INGE 权利人:BEIERSDORF AG 摘要:The invention relates to agents that are to be applied to the skin or hair and contain compounds for intensifying tanning of the skin and increasing melanin synthesis in skin or hair. The invention particularly relates to cosmetic or dermatological preparations. Using said preparations results in inducing and intensifying the tanning mechanisms of the skin, intensifying the hair color, and thus also increasing intrinsic protection of the skin or hair.
专利号:US-2005214275-A1 优先权日:2004-01-02 标题:Sequential ordered fatty acid alpha oxidation and delta9 desaturation are major determinants of lipid storage and utilization in adipocytes 发明人:GROSS RICHARD W 权利人:GROSS RICHARD W 摘要:A method for intentionally modulating by externally directing the amount of fat in a living mammal having adipocyte cells which comprises administering a compound thereto having reactive selectivity to the metabolic regulatory system of the cells of the animal to increase the fatty acid α oxidation of the lipid content in the differentiating adipocyte thereby reducing the amount of equivalents available for ATP synthesis.
专利号:EP-3686190-A1 优先权日:2013-07-11 标 题 :Synthesis of therapeutically active compounds
参考文献:10.1021/np100120c 摘要:Kotani H, Tanabe H, Mizukami H, Makishima M, Inoue M. Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor. J Nat Prod. 2010 Aug 27;73(8):1332–6. doi: 10.1021/np100120c.