CAS: 137-45-1; 1H-Pyrazol-3(2H)-One

相似化合物

2088458-39-1 28491-52-3 52867-35-3

上下游产品

CAS号288-13-1 吡唑

丙炔酸甲酯置于一水合肼体系中,用 甲醇 用作溶剂,化学反应 0.5H,以95%的收率获得乙二醇甲酸乙醚
参考文献:通过suzuki偶联优化3-嘧啶基吡唑并[1,5-A ]吡啶的放大;获取一系列3-(杂)芳基吡唑并[1,5-A ]吡啶的一般方法
标题:通过suzuki偶联优化3-嘧啶基吡唑并[1,5-A ]吡啶的放大;获取一系列3-(杂)芳基吡唑并[1,5-A ]吡啶的一般方法
摘要:我们已经开发出3-(杂)芳基吡唑并[1,5-A ]吡啶(例如3-(2,5-二氯嘧啶-4-基)吡唑并[1,5-A ]吡啶(8)的合成方法.)通过优化的合成方法和3-Pyrazolo [1,5-A ]吡啶硼酸酯10的suzuki偶联.这些条件适用于这些医学上重要的化合物的高通量化学和大规模合成.该化学反应的范围已进一步扩展到包括新型硼酸酯3-(4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-基)-6,7的合成和偶联-二氢-5 H-吡唑并[5,1-B ] [1,3]恶嗪(43).
Doi:10.1016/j.Tet.2012.04.094

专利信息

专利号:US-8680276-B2
优先权日:2009-03-06
标题 :Synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine
发明人：MOTTERLE RICCARDO; ARVOTTI GIANCARLO; BERGANTINO ELISABETTA; CASTELLIN ANDREA; FOGAL STEFANO; GALVAGNI MARCO
权利人:MOTTERLE RICCARDO; ARVOTTI GIANCARLO; BERGANTINO ELISABETTA; CASTELLIN ANDREA; FOGAL STEFANO; GALVAGNI MARCO
摘要:The present invention relates to the stereoselective synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine, as well as the conversion thereof, to give Moxifloxacin. Particularly, the present invention relates to a method for the synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine of formula (I) comprising: (a) the optical resolution by enzymatic hydrolysis of the intermediate dialkyl-1-alkylcarbonylpiperidine-2,3-dicarboxylate racemate of formula (II) to give, following isolation, the intermediate dialkyl-(2S,3R)-1-alkylcarbonyl-piperidine-2,3-dicarboxylate of formula (III) in which AIk is a straight or branched C1-C5 alkyl group; (b) the conversion of the intermediate (III) to (4aR,7aS)-1-alkylcarbonylhexahydrofuro[3,4-b]pyridine-5,7-dione of formula (IV) in which AIk has the meanings set forth above; (c) the conversion of the intermediate (IV) to (4aS,7as)-octahydro-1H-pyrrolo[3,4-b]pyridine of formula (I) with an optical purity above 99%.

专利号:US-5919969-A
优先权日:1996-06-05
标 题 :Synthesis of yellow couplers
发明人：CRAWLEY MICHAEL W
权利人:EASTMAN KODAK CO
摘要:The invention provides a method of synthesis of a image-dye forming coupler of formula (I) wherein X is a substituent linked to the coupler by an atom of oxygen, sulfur or nitrogen R1 is an alkyl or aryl group, R2 is a hydrogen atom or an alkyl group; R3 to R7 are the same or different and selected from a hydrogen atom and substituent groups; which method comprises the reaction of a compound of formula (II) wherein R and R1 are the same or different and are as defined above for R1 and X is as defined above with a compound of formula (III) wherein R2 to R7 are as defined above, in the presence of an inert organic solvent.

专利号:US-6159673-A
优先权日:1996-07-17
标 题:Oxonol compound, light-sensitive material and process for the synthesis of oxonol compound
发明人：NISHIGAKI JUNJI; DEGUCHI YASUAKI
权利人:FUJI PHOTO FILM CO LTD
摘要:An oxonol compound is represented by the following formula (I): in which Z is an atomic group that forms a cyclic amide ring; each of W1 and W2 independently is an atomic group that forms an acidic nucleus ring; and M is a cation. Other oxonol compounds, a light-sensitive material containing an oxonol compound and a process for the synthesis of an oxonol compound are also disclosed.

专利号:WO-2017089470-A1
优先权日:2015-11-27
标 题:Process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases
发明人：HOFMANN DAGMAR; HOFMANN JOSEFA; HEINRICH MARKUS
权利人:Friedrich-Alexander-Universität Erlangen-Nürnberg
摘要:The present invention relates to a process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases.

专利号:US-2013338369-A1
优先权日:2011-03-07
标 题 :Process for the Synthesis of Aminobiphenylene
发明人：HEINRICH MARKUS; PRATSCH GERALD
权利人:HEINRICH MARKUS; PRATSCH GERALD; BASF SE
摘要:The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.

专利号:WO-2023096623-A3
优先权日:2021-11-29
标 题:Synthesis of pyrazolone derivative compounds and their effects on cox enzymes
发明人：ÖNAY UÇAR EVREN; DEMÄ°RAYAK ÅžEREF; BERK BARKIN; YURTTAÅž LEYLA; BÄ°LTEKÄ°N KALELÄ° SEVDE NUR; ÅžAHÄ°N ZAFER
权利人:UNIV ISTANBUL MEDIPOL; UNIV ISTANBUL REKTOERLUEGUE; ANADOLU UENIVERSITESI
摘要:The invention is related to the synthesis of 8 pyrazolone derivative compounds and their activities on COX enzymes.