CAS: 13220-33-2; N-Methyl-3-Pyrrolidinol

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100858-32-0 100858-33-1 101385-90-4

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2,5-二氢-1-甲基-1H-吡咯置于sodium Hydroxide,Dimethyl Sulfide Borane,双氧水体系中,化学反应生成3-羟基-1-甲基四氢吡咯
参考文献:Hydroboration. 78. Reinvestigation Of The Hydroboration Of N-Substituted 3-Pyrrolines. Preparation Of N-Benzyl-3-Pyrrolidinol And N-Benzyl-3-Pyrrolidinylboronate Of Very High Enantiomeric Purity
标题:Hydroboration. 78. Reinvestigation Of The Hydroboration Of N-Substituted 3-Pyrrolines. Preparation Of N-Benzyl-3-Pyrrolidinol And N-Benzyl-3-Pyrrolidinylboronate Of Very High Enantiomeric Purity
摘要:
Doi:10.1021/jo00372A038

专利信息

专利号:US-7153960-B2
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
发明人：ZHOU JIACHENG; OH LYNETTE M; MA PHILIP; LI HUI-YIN; CONFALONE PASQUALE
权利人:BRISTOL MYERS SQUIBB CO
摘要:A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. n nThese compounds are useful as factor Xa inhibitors.

专利号:WO-2018154597-A1
优先权日:2017-02-22
标题:Process for synthesis of glycopyrronium bromide
发明人：REDDY G NITHUN; REDDY G SAMHITHA; REDDY G MADAALASA; RAMANI M; REDDY G PRATAP
权利人:GBR LABORATORIES PVT LTD; RACHANA PHARMA TECH
摘要:Provided herein are processes for preparation of glycopyrronium bromide comprising reaction of N-methylpyrrolidin-3-ol with compounds of Formula I or Formula II followed by additional steps.

专利号:US-5637757-A
优先权日:1995-04-11
标 题 :One-pot synthesis of ring-brominated benzoate compounds
发明人：HILL JOHN E; FAVSTRITSKY NICOLAI A; MAMUZIC RASTKO I; BHATTACHARYA BHABATOSH
权利人:GREAT LAKES CHEMICAL CORP
摘要:A method of preparing tetrabromobenzoate compounds from tetrabromophthalic anhydride by reacting tetrabromophthalic anhydride with alcohol in the presence of a decarboxylation catalyst. The reaction may be carried out in an excess of alcohol, or with a near stoichiometric amount of alcohol by performing the reaction in an inert solvent.

专利号:US-6566525-B1
优先权日:1998-09-17
标 题:Preparation of N-substituted-hydroxycycloalkylamine derivatives
发明人：KIM SEONG JIN; KIM KEON IL; YANG KYOUNG YOUL
权利人:SAMSUNG FINE CHEMICALS CO LTD
摘要:A process for the preparation of N-substituted-hydroxycycloalkylamine derivatives, that are useful intermediates for the synthesis of various organic chemicals including pharmaceutical and agrochemical compounds, represented by formula (1), by reacting a 1,2-dihydroxalkyl alcohol, represented by the following formula (2), with a thionyl halide to produce an intermediate 1,2-cyclosulfinylalkyl halide represented by the following formula (3); and then cyclizing that intermediate with an amine compounds represented by the following formula (4).In the above structural formuli, * represents an asymmetric carbon atom; R1 is hydrogen or an amino-protecting group; m is an integer of 1-3; and X is halogen. The reactant compounds as well as the compounds made according to this invention have the following substitution pattern:n=1, R2=OH, R3=H and m=1; n=1, R2=H, R3=CH2OH and m=2;n=2, R2=OH, R3=H; and m=2; and n=2, R2=H, R3=CH2OH and m=3.

专利号:US-9676783-B2
优先权日:2008-10-22
标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
权利人:ARRAY BIOPHARMA INC
摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

专利号:WO-2019013790-A1
优先权日:2017-07-12
标题:ANTIMICROBIAL COMPOUNDS AND USES THEREOF
发明人：REDDY HARIPRASADA; SEBAHAR PAUL; LOOPER RYAN
权利人:CURZA GLOBAL LLC; THE UNIV OF UTAH RESEARCH FOUNDATION
摘要:The invention relates to compounds of formula I: or pharmaceutically acceptable salts thereof. The compounds of formula I are antimicrobial agents which inhibit, for example, Mycobacterium tuberculosis (Mtb) H37Ra. The compounds of formula I also have anti-tuberculous activity, exhibiting limited cytotoxicity, and inhibiting protein synthesis. The invention also relates to methods of making compounds of Formula I, as well as methods of using the compounds of Formula I for the treatment of bacterial infections, particularly tuberculosis.