专利号:WO-2009018504-A1 优先权日:2007-08-01 标题 :Process for the synthesis of diaminopyridine and related compounds 发明人:RITTER JOACHIM C 权利人:DU PONT; RITTER JOACHIM C 摘要:A process is provided for the synthesis of a diaminopyridine, such as 2,6-diaminopyridine and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a chlorine-ammonia displacement in the presence of a copper source.
专利号:WO-2006025724-A1 优先权日:2004-09-02 标题:IMPROVEMENTS TO SYNTHESIS, PHARMACEUTICAL COMPOSITIONS AND USES OF SODIUM PENTABORATE PENTAHYDRATE (NaB5O8.5H2O) 发明人:GALVAN PEREZ JUAN PABLO 权利人:GALVAN PEREZ JUAN PABLO 摘要:The invention relates to an improved method for the synthesis of sodium pentaborate pentahydrate (NaB5O8.5H2O), consisting in reacting disodium tetraborate decahydrate (DTBD, Borax) and orthoboric acid (OBA, boric acid). The inventive method is performed over a period of no more than five days and does not require the use of fungal strains. The invention also relates to the product thus obtained, which is intended to boost the immune system against ailments caused by bacteria and viruses, to the pharmaceutical compositions thereof and to the use of same in relation to said ailments.
专利号:US-2025034607-A1 优先权日:2021-12-03 标题 :Process of Synthesizing (R)-3-aminobutan-1-ol 发明人:BOBKO MARK; FUERST DOUGLAS; MORGAN CHRISTOPHER 权利人:VIIV HEALTHCARE CO 摘要:The present invention relates to an aminotransaminase useful in the synthesis of (R)-3-aminobutan-1-ol (RABO). The present invention also provides a process of preparing (R)-3-aminobutan-1-ol (RABO) with the disclosed aminotransaminase.
专利号:WO-2004074215-A1 优先权日:2003-02-03 标 题 :Process for preparation of clopidogrel, its salts and pharmaceutical compositions 发明人:NADKARNI SUNIL SADANAND; PATEL HASMUKH MATHURBHAI 权利人:NADKARNI SUNIL SADANAND; PATEL HASMUKH MATHURBHAI 摘要:The invention discloses an improved process for racemization of methyl (R)Â(-) alpha-(2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate , a stereoisomer formed in the synthesis of clopidogrel i.e. methyl (S)-(+)-alpha (2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate or its salts. The invention is also for an improved process for production of clopidogrel or its pharmaceutically acceptable salts. The invention further discloses novel clopidogrel salts and pharmaceutical compositions comprising them.
专利号:EP-0891224-B1 优先权日:1996-04-01 标 题:A method of preparing a vinyl acetate catalyst employing an alkali metal borate 发明人:NICOLAU IOAN; COLLING PHILIP M 权利人:HOECHST CELANESE CORP 摘要:A method for preparing an unsaturated ester synthesis catalyst wherein a catalytic carrier is impregnated with a water-soluble palladium salt and a water-soluble gold compound followed by precipitating the water-soluble palladium salt and the water-soluble gold compound to water-insoluble palladium and gold compounds with a fixing composition containing an alkali metal borate. The fixed palladium and gold compounds are reduced to palladium and gold metal with ethylene or hydrazine followed by impregnating the carrier with an alkali metal acetate such as potassium acetate. The unsaturated ester synthesis catalyst can be employed to synthesize vinyl acetate with reduced heavy ends.
专利号:US-2018230111-A1 优先权日:2004-05-21 标 题:Synthesis of tetracyclines and analogues thereof
[参考文献]: Elder Dp, Et Al. Pharmaceutical Excipients - Quality, Regulatory And Biopharmaceutical Considerations. Eur J Pharm Sci. 2016 May 25;87:88-99. [参考文献]: Ahmed O Alnajjar, Et Al. Development Of A Cze Method For The Quantification Of Pseudoephedrine And Cetirizine. J Chromatogr Sci. 2014 Oct;52(9):1104-8. [参考文献]: Diego A Fernández, Et Al. Evaluation Of The Intestinal Permeability And Cytotoxic Effects Of Cylindrospermopsin. Toxicon. 2014 Dec:91:23-34. [参考文献]: Eric W Crick, Et Al. Correlation Of 3-Mercaptopropionic Acid Induced Seizures And Changes In Striatal Neurotransmitters Monitored By Microdialysis. Eur J Pharm Sci. 2014 Jun 16:57:25-33. [参考文献]: Heidi Turkia, Et Al. Capillary Electrophoresis With Laser-Induced Fluorescence Detection For Studying Amino Acid Uptake By Yeast During Beer Fermentation. Talanta. 2015 Jan:131:366-71.
合成参考文献
摘要:CHEMICAL PROFILE: BORATES, 1985 摘要:Weed Science Society of America. Herbicide Handbook. 5th ed. Champaign, Illinois: Weed Science Society of America, 1983., p. 63 摘要:Singh V, Singh SP; Indian J Agron 29 (4): 545-6 (1984) 摘要:American Conference of Governmental Industrial Hygienists. Documentation of Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices for 2001. Cincinnati, OH. 2001., p. 1 摘要:USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present