CAS: 118-56-9; 3,3,5-Trimethylcyclohexyl 2-Hydroxybenzoate

化学文摘社编号118-56-9,由于能够吸收紫外线辐射,通常用作日光屏配方的成份;被归类为化学紫外线过滤器,特别有效吸收紫外线,主要负责太阳晒伤和导致皮肤癌;同源体是无色的,淡黄色的无色液体,有温味的气味,在有机溶剂中溶解,但水溶性有限;其化学结构具有盐酸衍生物,有助于保护皮肤免受紫外线照射的危害;除其光防护特性外,同源体还作为其他日光屏剂的稳定剂,提高该制剂的总体效力;监管评估评价了其在化妆品中使用的安全性,并在确定浓度限度内使用时被普遍确认为安全;然而,持续的研究继续监测其对环境的影响和对人类健康的潜在影响.

结构式图片

相似化合物

1131587-74-0 1131605-47-4 31481-49-9

欧盟法规

REACH注册ECHA物质欧盟化妆品法规附录六-准用紫外线吸收剂清单ECHA物质C&L通报REACH预注册

上下游产品

3,3,5-trimethylcyclohexanol methyl salicylate

合成工艺路线路线简述

  • 合成目标产物 Homosalate 主要起始原料 3,3,5-Trimethylcyclohexanol And Methyl Salicylate
  • (文献来源)合成步骤主要原料 3,3,5-Trimethylcyclohexanol 和 Methyl Salicylate
3,3,5-三甲基环己醇,水杨酸甲酯置于potassium Carbonate,溴化铵体系中,化学反应 13.0H,以81.1%的收率获得原膜散酯
参考文献:一种胡莫柳酯的合成方法
标题:一种胡莫柳酯的合成方法
摘要:本发明提供了一种以水杨酸甲酯或者水杨酸乙酯和3,3,5-三甲基环己醇在碱催化下经酯交换反应合成胡莫柳酯的方法.该方法操作简便,转化率高,经济环保,适合工业化生产.

海关参考信息

专利信息


专利号:US-7662401-B2
优先权日:2002-04-08
标 题 :Administration of extracts of nonfruiting nonphotosynthetic filamentous bacteria for increasing the endogenous synthesis of superoxide dismutase
发明人:MAHE YANN; MEYBECK ALAIN
权利人:OREAL
摘要:The present invention relates to the cosmetic or pharmaceutical use of an extract of a nonfruiting nonphotosynthetic filamentous bacterium in a composition containing a cosmetically or pharmaceutically acceptable medium, as an agent increasing the endogenous synthesis of superoxide dismutase, in particular for preventing and/or limiting the formation of free radicals and/or removing the free radicals present in cells; in addition, the invention relates to a composition comprising at least one extract of Vitreoscilla filiformis and lycopene.

专利号:US-2012003164-A1
优先权日:1998-12-30
标题 :Cosmetic or dermatological composition containing an active agent which stimulates synthesis of the protein hsp 32 in the skin
发明人:NIZARD CARINE; MOREAU MARIELLE; BONTE FREDERIC
权利人:NIZARD CARINE; MOREAU MARIELLE; BONTE FREDERIC; DIOR CHRISTIAN PARFUMS
摘要:A dermatological or cosmetological composition for an external topical administration, included together with pharmaceutically and/or cosmetologically acceptable excipients: at least one UVA-stabilizing and/or UVB-stabilizing screening agent, at least one compound capable of activating the endogenous synthesis of Heat Shock Protein (HSP) 32 or a functional peptide fragment of such a protein, and forskolin or any extract containing it.

专利号:WO-2024133119-A1
优先权日:2022-12-19
标 题:Process for the synthesis of isophorone in the liquid phase, including recycling of the by-products
发明人:RUPPIN CHRISTOPHE
权利人:ARKEMA FRANCE
摘要:The present invention relates to a continuous process for the synthesis of isophorone in the liquid phase by alkaline self-condensation of acetone, comprising the following successive steps: a) continuously injecting, through a tubular reactor (R), a stream of an aqueous alkali hydroxide solution and a stream of an organic solution comprising acetone and by-products recycled in step g), followed by b) condensation reaction of the acetone in the tubular reactor (R), then c) distillation of the reaction mixture from the tubular reactor (R), then d) separation of the concentrated raw reaction product from the distillation of step c), resulting in an alkaline aqueous phase and an organic phase containing isophorone, then e) distillation of the organic phase containing the isophorone recovered in the preceding step, then f) distillation of the polycondensation sub-products from the bottom of the column (D2) from the preceding distillation, then g) recycling, to the tubular reactor (R), of the stream from the column head of the preceding distillation (D3), said stream comprising xylitones and/or isoxylitones.

专利号:US-7128914-B2
优先权日:2001-11-14
标 题 :Product containing an extract of red algae of the genus Porphyra and methods for protecting cells
发明人:LECLERC CHRISTIAN; PAUL FRANCOIS
权利人:LARENA
摘要:A composition that induces synthesis of stress protective proteins during application of physical or physiological stresses, or physiopathological aggressions on cells including a water-alcohol extract of red algae, taurine and derivatives: about 1 to about 5%, floridoside and derivatives: about 10 to about 25%, one or more of carotenoids and PUFAs, one or more water-soluble vitamins, one or more free amino acids and derivatives, and one or more pigments; and a method of protecting skin against wrinkle formation including administering a therapeutically effective amount of a composition including a water-alcohol extract of red algae that induces synthesis of stress protective proteins during physical or physiological stresses, or physiopathological aggressions on skin cells.

专利号:EP-1140000-B1
优先权日:1998-12-30
标 题 :Cosmetic or dermatological composition containing an active principle stimulating hsp 32 protein synthesis in the skin and cosmetic treatment method
发明人:NIZARD CARINE; MOREAU MARIELLE; BONTE FREDERIC
权利人:DIOR CHRISTIAN PARFUMS
摘要:The invention concerns a dermatological or cosmetological composition, characterised in that it contains at least a compound capable of activating HSP 32 endogenetic synthesis or a functional peptide fragment of such a protein with pharmaceutically and/or cosmetologically acceptable carriers. The invention also concerns the use of a compound selected from the group consisting of procyanidolic oligomers (PCO) and their derivatives, caffeic acid esters and their derivatives and mixtures of said compounds, for preparing a composition designed to activate endogenetic synthesis of HSP 32 or a functional peptide fragment of such a protein.

专利号:US-2024009104-A1
优先权日:2021-02-09
标 题:Process for extraction and hemi-synthesis of pyranoanthocyanins and skincare cosmetic formulations containing them
发明人:REIS FERNANDES IVA LUZIA; DA SILVA OLIVEIRA PINTO DA SILVA JOANA ALEXANDRA; DA CRUZ BATISTA MATEUS NUNO FILIPE; PEREIRA DE FREITAS VICTOR ARMANDO; COUTO OLIVEIRA HELDER JOSÉ; CARNEIRO ARAUJO PAULA ALEXANDRA; RODRIGUES CORREIA PATRICIA; MARTINS PEREIRA ANA RITA
权利人:UNIV DO PORTO; REQUIMTE REDE DE QUIM E TECNOLOGIA
摘要:A process of extraction of anthocyanins from different foodstuffs or by-products, and their conversion into pyranoanthocyanins compounds, which can be used as pigments having new colors and improved stability to be incorporated into skincare formulations in particular anti-ageing and sun-protection formulations. Cosmetic formulations having the pigments with improved properties of UV protection and moisturizing, anti-dark spots, anti-wrinkles and wound-healing, which can be associated with interesting colors ranging from red to blue depending on the selected pigments in the composition and in the formula composition. The present invention is in the area of organic chemistry, biochemistry, pharmacology and cosmetics for skincare.
上海西加生物科技有限公司
⚠️ 未注册 · 未认证企业
⚠️ 该商家尚未完成注册及企业认证,请用户仔细辨别,谨慎交易。
数据来源于公开网络搜索,平台未作核实,请自行辨别。
🏢敬请 企业认领
🏬开设公司展台
📢获取免费会员权益
🎖️点亮专属注册企业标签
📇展现公司完整信息 样本查看立即注册认领 →
网址: http://www.sigachem.com
企业联系电话:18901978308👤
📞上海西加生物科技有限公司 ⚠️参考联系方式
联系人:龚经理
电话:18901978308
手机:13764598896

邮箱:grace8018@163.com
通信地址: 上海市崇明区新河镇新申路921弄2号W区175室
邮编:
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领,请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实,百琢研不参与任何交易。企业认领注册入口→

地址:上海市崇明区新河镇新申路921弄2号W区175室
⚠️ 未注册 · 未认证企业
注册入口 备注: 📌 数据来源说明:本展台内容基于各搜索引擎等公开数据整理,仅作展示用途。请用户自行辨别
✉️ 若企业需抹除展台内容或有异议, 请通过页面底部联系方式告知我们,我们会尽快处理。
南京科思化学股份有限公司
⚠️ 未注册 · 未认证企业
⚠️ 该商家尚未完成注册及企业认证,请用户仔细辨别,谨慎交易。
数据来源于公开网络搜索,平台未作核实,请自行辨别。
🏢敬请 企业认领
🏬开设公司展台
📢获取免费会员权益
🎖️点亮专属注册企业标签
📇展现公司完整信息 样本查看立即注册认领 →
网址: http://www.cosmoschem.com
电话: 025-66987788👤
📞南京科思化学股份有限公司 ⚠️参考联系方式

销售电话:025-66987788
邮箱:cosmos@cosmoschem.com
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领,请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实,百琢研不参与任何交易。企业认领注册入口→

⚠️ 未注册 · 未认证企业
注册入口 备注: 📌 数据来源说明:本展台内容基于各搜索引擎等公开数据整理,仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议, 请通过页面底部联系方式告知我们,我们会尽快处理。
常州市天华制药有限公司
⚠️ 未注册 · 未认证企业
⚠️ 该商家尚未完成注册及企业认证,请用户仔细辨别,谨慎交易。
数据来源于公开网络搜索,平台未作核实,请自行辨别。
🏢敬请 企业认领
🏬开设公司展台
📢获取免费会员权益
🎖️点亮专属注册企业标签
📇展现公司完整信息 样本查看立即注册认领 →
网址: http://www.tianhuachem.com
电话: 0519-82891186👤
📞常州市天华制药有限公司 ⚠️参考联系方式

销售电话:0519-82891186
邮箱: tianhua@tianhuachem.com
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领,请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实,百琢研不参与任何交易。企业认领注册入口→

⚠️ 未注册 · 未认证企业
注册入口 备注: 📌 数据来源说明:本展台内容基于各搜索引擎等公开数据整理,仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议, 请通过页面底部联系方式告知我们,我们会尽快处理。
杭州法玛化学品有限公司
⚠️ 未注册 · 未认证企业
⚠️ 该商家尚未完成注册及企业认证,请用户仔细辨别,谨慎交易。
数据来源于公开网络搜索,平台未作核实,请自行辨别。
🏢敬请 企业认领
🏬开设公司展台
📢获取免费会员权益
🎖️点亮专属注册企业标签
📇展现公司完整信息 样本查看立即注册认领 →
网址: http://www.hzph.com
企业联系电话:0571-87040515👤
📞杭州法玛化学品有限公司 ⚠️参考联系方式

电话:0571-87040515

传真:0571-87214761
邮箱:chenhk@hzph.com
通信地址: 上城区庆联大厦1201室
邮编: 310003
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领,请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实,百琢研不参与任何交易。企业认领注册入口→

地址:上城区庆联大厦1201室
⚠️ 未注册 · 未认证企业
注册入口 备注: 📌 数据来源说明:本展台内容基于各搜索引擎等公开数据整理,仅作展示用途。请用户自行辨别
✉️ 若企业需抹除展台内容或有异议, 请通过页面底部联系方式告知我们,我们会尽快处理。
江苏清泉化学股份有限公司
⚠️ 未注册 · 未认证企业
⚠️ 该商家尚未完成注册及企业认证,请用户仔细辨别,谨慎交易。
数据来源于公开网络搜索,平台未作核实,请自行辨别。
🏢敬请 企业认领
🏬开设公司展台
📢获取免费会员权益
🎖️点亮专属注册企业标签
📇展现公司完整信息 样本查看立即注册认领 →
网址: http://www.qqpharm.com
企业联系电话:0571-86589381/2/3👤
📞江苏清泉化学股份有限公司 ⚠️参考联系方式
联系人:市场部
电话:0571-86589381/2/3

传真:0571-86589380
邮箱:sales1@qqpharm.com
通信地址: 江苏省盐城市滨海沿海化工园区
邮编: 224555
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领,请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实,百琢研不参与任何交易。企业认领注册入口→

地址:江苏省盐城市滨海沿海化工园区
⚠️ 未注册 · 未认证企业
注册入口 备注: 📌 数据来源说明:本展台内容基于各搜索引擎等公开数据整理,仅作展示用途。请用户自行辨别
✉️ 若企业需抹除展台内容或有异议, 请通过页面底部联系方式告知我们,我们会尽快处理。
浙江新化化工股份有限公司
⚠️ 未注册 · 未认证企业
⚠️ 该商家尚未完成注册及企业认证,请用户仔细辨别,谨慎交易。
数据来源于公开网络搜索,平台未作核实,请自行辨别。
🏢敬请 企业认领
🏬开设公司展台
📢获取免费会员权益
🎖️点亮专属注册企业标签
📇展现公司完整信息 样本查看立即注册认领 →
网址: http://www.xhchem.com
企业联系电话:0571-64755918,64755919👤
📞浙江新化化工股份有限公司 ⚠️参考联系方式
联系人:张先生
电话:0571-64755918,64755919
手机:18157198002
传真:0571-64755178,64755122
邮箱:zxli@xhchem.com
通信地址: 浙江省建德市洋溪街道新安江路909号
邮编: 311607
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领,请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实,百琢研不参与任何交易。企业认领注册入口→

地址:浙江省建德市洋溪街道新安江路909号
⚠️ 未注册 · 未认证企业
注册入口 备注: 📌 数据来源说明:本展台内容基于各搜索引擎等公开数据整理,仅作展示用途。请用户自行辨别
✉️ 若企业需抹除展台内容或有异议, 请通过页面底部联系方式告知我们,我们会尽快处理。
第 1 / 1 页
现货

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献


1: Kim TH, Shin BS, Kim KB, Shin SW, Seok SH, Kim MK, Kim EJ, Kim D, Kim MG, Park ES, Kim JY, Yoo SD. Percutaneous absorption, disposition, and exposure assessment of homosalate, a UV filtering agent, in rats. J Toxicol Environ Health A. 2014;77(4):202-13. doi: 10.1080/15287394.2013.861376. doi: 10.1073/pnas.1703995114. Epub 2017 Jul 24.
3: Yang C, Lim W, Bazer FW, Song G. Homosalate aggravates the invasion of human trophoblast cells as well as regulates intracellular signaling pathways including PI3K/AKT and MAPK pathways. Environ Pollut. 2018 Dec;243(Pt B):1263-1273. doi: 10.1016/j.envpol.2018.09.092. Epub 2018 Sep 21. doi: 10.1016/j.jchromb.2013.08.006. Epub 2013 Aug 8. doi: 10.1177/0748233717718974. Epub 2017 Sep 7. doi: 10.1111/j.1365-2605.2012.01280.x. Review. doi: 10.1002/jat.3525. Epub 2017 Oct 9. doi: 10.1097/DER.0000000000000300.
11: Gerberick GF, Ryan CA. Contact photoallergy testing of sunscreens in guinea pigs. Contact Dermatitis. 1989 Apr;20(4):251-9. doi: 10.1080/17435390.2016.1206148. Epub 2016 Jul 19. doi: 10.1016/j.envres.2017.11.015. doi: 10.1016/j.chroma.2017.06.039. Epub 2017 Jun 15. doi: 10.1021/np7007297. Epub 2008 May 31. doi: 10.1016/j.marpolbul.2015.10.077. Epub 2015 Nov 12. doi: 10.1038/s41598-017-08013-x.

合成参考文献


摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
摘要:Benson HA, Sarveiya V, Risk S, Roberts MS. Influence of anatomical site and topical formulation on skin penetration of sunscreens. Ther Clin Risk Manag. 2005 Sep;1(3):209–18.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知