CAS: 118-31-0; Naphthalen-1-Ylmethanamine

相似化合物

39110-74-2 256222-11-4 2243-81-4

上下游产品

CAS号86328-84-9 4-methyl-N-(nap... | CAS号13504-46-6 1-苯基醛肟 | CAS号86-53-3 1-萘甲腈 | CAS号86-52-2 1-氯甲基萘 | CAS号55210-79-2 1-(azidomethyl)... | CAS号4780-79-4 1-萘甲醇 | CAS号6968-09-8 2-(naphthalen-1... | CAS号3163-27-7 1-溴甲基萘 | CAS号66-77-3 1-萘甲醛 | CAS号86-86-2 萘乙酰胺 | CAS号14393-12-5 苄萘-1-甲胺 | CAS号4780-79-4 1-萘甲醇 | CAS号18818-37-6 2-naphthalen-1-... | CAS号66-77-3 1-萘甲醛 | CAS号2243-81-4 萘-1-甲酰胺 | CAS号86-53-3 1-萘甲腈 | CAS号1355943-34-8 3-bromo-N-(naph... | CAS号2387-23-7 N,N’-二环己基脲 | CAS号846-63-9 2-(1-萘基)-5-苯基恶唑 | CAS号65472-88-0 萘替芬

1-萘甲醇置于potassium Tert-Butylate,氨体系中,用 甲苯 用作溶剂,150.0 °C,700.01 Kpa 条件下,反应 24.0H,以59%的收率获得1-萘甲基胺
参考文献:用于胺和氨与醇的一般和选择性n-烷基化的可重复使用的co纳米颗粒
标题:用于胺和氨与醇的一般和选择性n-烷基化的可重复使用的co纳米颗粒
摘要:报道了一种通用的钴催化胺与醇的n-烷基化反应,利用氢方法制备不同种类的胺.这种转化的最佳催化剂是通过热解特定的模板材料来制备的,该模板材料是通过混合钴盐,氮配体和胶态二氧化硅原位生成的,然后去除二氧化硅.应用这种新型co纳米粒子基材料,>100伯胺,仲胺和叔胺(包括n-甲胺)和选定的药物分子可以从廉价且容易获得的醇和胺或氨开始方便地制备.
Doi:10.1039/d1Sc05913K

专利信息

专利号:US-7279572-B2
优先权日:2003-05-22
标题:Process for the 2-stage synthesis of hexanitrohexaazaisowurtzitane starting from a primary amine
发明人：CAGNON GUY; ECK GENEVIEVE; HERVE GREGOIRE; JACOB GUY
权利人:SNPE MATERIAUX ENERGETIQUES
摘要:A subject-matter of the present invention is a novel process for the synthesis of hexanitrohexaazaisowurtzitane (HNIW), a compound of use as energetic filler in powders, propellants and explosives. n This process comprises a first stage of reaction of an α,β-dicarbonyl derivative with a primary amine which makes it possible to form a hexasubstituted hexaazaisowurtzitane derivative. n The HNIW is subsequently obtained directly, in a single reaction stage, by nitration of the hexasubstituted hexaazaisowurtzitane derivative. n This process, in only 2 stages starting from a primary amine, is particularly simple and inexpensive.

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:US-10266565-B2
优先权日:2011-04-12
标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN
权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

专利号:WO-9931124-A1
优先权日:1997-12-12
标 题:Cholic acid-based scaffolds for multidimensional molecular presentation of peptides
发明人：HOEEG-JENSEN THOMAS
权利人:NOVO NORDISK AS; HOEEG JENSEN THOMAS
摘要:A solid phase method for the synthesis of a plurality of differently substituted cholic acid scaffolds with a wide variety of peptide chain, pseudo-peptide chain or peptoid chain substitutents, as leads or compounds of potential therapeutic interest. The substituted cholic acids are prepared by initial solution synthesis of a scaffold holding amino acids with 3 orthogonal protecting groups. Subsequent solid-phase synthesis provides the build-up of the target molecules, either as discretes or in mixture. The molecules may be screened on the resin or cleaved from the resin and then screened in solution. The method disclosed here provides an easy and fast access to highly diverse compounds, potential peptide mimetics and potential leads for compounds of therapeutic interest. The method is amenable to automatization.

专利号:US-9018371-B2
优先权日:2007-03-07
标 题 :Adenosine derivatives, method for the synthesis thereof, and the pharmaceutical compositions for the prevention and treatment of the inflammatory diseases containing the same as an active ingredient
发明人：JEONG LAK SHIN; KIM HEA OK; JACOBSON KENNETH A; CHOE SEUNG AH
权利人:JEONG LAK SHIN; KIM HEA OK; JACOBSON KENNETH A; CHOE SEUNG AH; FM THERAPEUTICS CO LTD; US OF AMERICA AS REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES THE OFFICE OF TECHNO
摘要:Disclosed are adenosine derivatives, methods for the synthesis thereof, and pharmaceutical compositions for the prevention and treatment of inflammatory diseases, comprising the same as an active ingredient. The adenosine derivatives have high binding affinity and selectivity for adenosine receptors, especially for A 3 adenosine receptors and act as A 3 adenosine receptor antagonists, and exhibit anti-inflammatory activity. Thus, the adenosine derivatives are useful in the prevention and treatment of inflammatory diseases.

专利号:US-6906046-B2
优先权日:2000-12-22
标题 :Pharmaceutical uses and synthesis of benzobicyclooctanes
发明人：JACKSON RANDY W; DARWISH IHAB; BAUGHMAN TED A; HOWBERT J JEFFRY
权利人:CELLTECH R & D INC
摘要:Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual compounds.