CAS: 110962-94-2; 3-(2-Cyanoethyl) 5-Methyl 4-(2,3-Dichlorophenyl)-2,6-Dimethyl-1,4-Dihydropyridine-3,5-Dicarboxylate
该化合物是一个化学化合物,其结构复杂,包括一个由各种功能组替代的环.该化合物具有二氯苯杂交性,有助于其潜在的生物活动和亲脂性.二氢和酯功能的存在表明它可能表现出有趣的再活动性和溶性.二乙基组可以加强其极性,有可能影响其与生物目标的互动.此外,丙烯环上的甲基组可能影响到其...
- 英文名称3-(2-Cyanoethyl) 5-Methyl 4-(2,3-Dichlorophenyl)-2,6-Dimethyl-1,4-Dihydropyridine-3,5-Dicarboxylate
- 中文名称4-(2,3-二氯-苯基)-2,6-二甲基-1,4-二氢-吡啶-3,5-二羧酸 3-(2-氰基-乙基)酯 5-甲酯
- IUPAC名称3-(2-cyanoethyl) 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- 其它别名4-(2,3-Dichloro-Phenyl)-2,6-Dimethyl-1,4-Dihydro-Pyridine-3,5-Dicarboxylic Acid 3-(2-Cyano-Ethyl) Ester 5-Methyl Ester; 3-(2-Cyanoethyl) 5-Methyl 4-(2',3'-Dichlorophenyl)-2,6-Dimethyl-1,4-Dihydropyridine-3,5-Dicarboxylate; Clevidipine Butyrate Impurity ⅵ; Clevidipine Butyrate-5; Clevidipine Butyrate Impurity 6; 4-(2,3-Dichloro-Phenyl)-2,6-Dimethyl-1,4-Dihydro-Pyridine-3,5-Dicarboxylic Acid 3-(2-Cyano-Ethyl); 5-O-(2-Cyanoethyl) 3-O-Methyl 4-(2,3-Dichlorophenyl)-2,6-Dimethyl-1,4-Dihydropyridine-3,5-Dicarboxylate; 4-(2,3-Dichloro-Phenyl)-2,6-Dimethyl-1,4-Dihydro-Pyridine-3,5-Dicarboxylic Acid 3-(2-Cyano-Ethyl) Es
- CAS编号110962-94-2
- MFCD编号:MFCD17215542
- FDA UNII编号:77AD3HZ6QG
- 分子式:C19H18Cl2N2O4
- 分子量:409.27
- 产品CID: 146102
- 产品分类原料药 → 循环系统用药 → 抗高血压病药
物理性质
MSDS等安全信息
上下游产品
(E/Z)-methyl 2-(2,3-dichlorobenzylidene)acetoacetate (Z)-3-Amino-but-2-enoic acid 2-cyano-ethyl ester acetoacetic acid methyl ester 2,3-dichlorobenzylaldehyde (+)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-3-pyridinecarboxylic acid合成工艺路线路线简述
2,3-二氯苯甲醛置于哌啶,溶剂黄146体系中,用 异丙醇,苯 用作溶剂,化学反应 5.0H,反应生成氯维地平酯
参考文献:Synthesis And Antihypertensive Activities Of New 1,4-Dihydropyridine Derivatives Containing A Nitrooxy Moiety At The 3-Ester Position.
标题:Synthesis And Antihypertensive Activities Of New 1,4-Dihydropyridine Derivatives Containing A Nitrooxy Moiety At The 3-Ester Position.
摘要:研究合成了一系列在3-酯位含有硝氧基的二氢吡啶类新化合物.这些化合物的降压活性经检验并与尼非地平相比较;其中一些相对具有较强的活性.同时还讨论了结构与活性之间的关系.
Doi:10.1248/cpb.41.108
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
2902700000-异丙基苯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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专利信息
专利号:US-8455655-B2
优先权日:2010-05-07
标题:Preparation of dihydropyridines
发明人：VISHNU NEWADKAR RAVINDRANATH; PURUSHOTTAM JOSHI ANIL; KUMAR SINGH SANTOSH
权利人:VISHNU NEWADKAR RAVINDRANATH; PURUSHOTTAM JOSHI ANIL; KUMAR SINGH SANTOSH; LESVI LABORATORIOS SL
摘要:The invention relates to a method and compounds for the preparation of clevidipine butyrate, a very short acting hypertensive calcium antagonist, as well as the synthesis of these compounds useful for the preparation of clevidipine (also known as clevidipine butyrate). Moreover the invention also discloses polymorphic forms of clevidipine butyrate, useful for the preparation of pharmaceutical compositions, and processes to prepare them.
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主要参考文献
参考标题:Mild And Facile Cleavage Of 2-Cyanoethyl Ester Using Sodium Sulfide Or Tetrabutylammonium Fluoride. Synthesis Of 1,4-Dihydropyridine Monocarboxylic Acids And Unsymmetrical 1,4-Dihydropyridine Dicarboxylates.作者:Toshihisa Ogawa,Katsuo Hatayama,Hiroshi Maeda,Yasuyuki Kita
摘要:Several 3-(2-Cyanoethyl)-1, 4-Dihydropyridine Carboxylates (16) Were Prepared In Moderate To Good Yields By Means Of The Hantzsch Reaction. Treatment Of These Carboxylates With A Weak Base Such As Sodium Sulfide Or Tetrabutylammonium Fluoride At Room Temperature Afforded Smoothly The Corresponding 1, 4-Dihydropyridine Monocarboxylic Acids (18) In Good Yields. The Monocarboxylic Acids 18N And 18O Were Esterified With 2-Nitrooxypropanol Or N-(2-Hydroxyethyl)Nicotinamide P-Toluenesulfonic Acid Salt To Afford The Selective Coronary Vasodilators Cd-349 (5) And Cd-832 (6), Respectively.
合成参考文献
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2017).
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