CAS: 107648-78-2; (6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-Thiazol-4-yl)-2-Methoxyiminoacetyl]Amino]-3-[(1-Methylpyrrolidin-1-Ium-1-yl)Methyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate,Sulfuric Acid

该化合物是一种被归类为第四代甲状腺素抗生素的广谱性脑膜结膜素抗生素,主要用于治疗各种细菌感染,特别是由包括肺炎菌菌在内的阴性细菌引起的感染.硫酸硫酸硫酸盐表现出对乙状乳腺的高度稳定性,乙状乳腺是某些细菌产生的酶,可以停止其他抗生素.该化合物通常通过静脉注射或肌肉内施用,允许在体内迅速吸收和分配.其行动机制包括抑制细菌细胞壁合成,导致细胞分解和死亡.其作用一般是良好的,但潜在的副作用可能包括过敏反应,胃肠扰动和血液细胞细胞的改变.硫酸盐形式可以增强溶解的溶解性和稳定性,使之适合临床使用.建议任何抗生素,适当的敏感度测试,以确保对特定病原体的有效性.

英文名称(6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-Thiazol-4-yl)-2-Methoxyiminoacetyl]Amino]-3-[(1-Methylpyrrolidin-1-Ium-1-yl)Methyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate,Sulfuric Acid
中文名称头孢吡肟硫酸盐
IUPAC名称(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;sulfuric acid
其它别名(6R,7R)-7-[[(2E)-2-(2-Amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]°Ct-2-ene-2-carboxylic acid sulfate
CAS编号107648-78-2
MFCD编号:MFCD09264315
FDA UNII编号:YP33Y0FYAE
分子式:C19H25N6O5S2.HO4S分子量:578.645
产品CID: 114548
同类组份化合物CAS103296-32-8 (compound E)123171-59-5 (2HCl hydrate)88040-23-7 (free base)107648-78-2 (sulfate)107648-80-6 (2HCl)
产品分类原料药 → 抗生素类药物 → 头孢菌素类药

相似结构搜索
InChIKey: JCRAHWHSZYCYEI-LSGRDSQZSA-N
1S/C19H24N6O5S2.H2O4S/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11;1-5(2,3)4/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26
计算化学: 氢键受体数14.0氢键供体数4.0可旋转键数6.0

物理性质

PSA:286.56
LogP:1.009
外观形态White powder
储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
产品应用该化合物是抗生素,

MSDS等安全信息

上下游产品

1-(2-Amino-thiazol-4-yl)-2-(5-methyl-2-thioxo-[1,3,4]thiadiazol-3-yl)-ethane-1,2-dione 1-(O-methyl-oxime) 13H19N3O3S*HIC13H19N3O3S*HI (2-Amino-thiazol-4-yl)-[(Z)-methoxyimino]-thioacetic acid S-(5-methyl-[1,3,4]thiadiazol-2-yl) ester 1-(2-Amino-thiazol-4-yl)-2-(4-methyl-5-thioxo-4,5-dihydro-tetrazol-1-yl)-ethane-1,2-dione 1-(O-methyl-oxime)

合成工艺路线路线简述

专利信息

专利号:FI-119811-B
优先权日:1991-09-10
标题:Synthesis of 2- (2-aminothiazol-4-yl) -2-methoxyiminoacetyl chloride hydroxychloride and process for its preparation

专利号:CN-107201391-B
优先权日:2017-07-04
标题 :Synthesis method of cefepime hydrochloride

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品牌试剂参考报价(招募中)

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主要参考文献

1: Kummer M, Šestáková N, Theurillat R, Huynh-Do U, Endimiani A, Sendi P, Thormann W. Monitoring of cefepime in urine by micellar electrokinetic capillary chromatography with ultraviolet detection and liquid chromatography coupled to mass spectrometry. J Sep Sci. 2018 Nov;41(21):4067-4074. doi: 10.1002/jssc.201800763. Epub 2018 Sep 25. 74(1):e55-e63. doi: 10.2146/ajhp150733. Epub 2016 Dec 22. 59(4):458-63. 28(11):1788-97. doi: 10.1002/elps.200600537. 59(4):243-6. 79(8):1446-51. doi: 10.4315/0362-028X.JFP-15-548. 61(9):4067-4086. doi: 10.1021/acs.jmedchem.8b00091. Epub 2018 Apr 20.
8: Schlesser V, Hecq JD, Vanbeckbergen D, Jamart J, Galanti LM. Effect of freezing, long-term storage, and microwave thawing on the stability of cefepime in 5% dextrose infusion polyvinyl chloride bags. Int J Pharm Compd. 2002 Sep- Oct;6(5):391-4. 26(10):1081-6. doi: 10.2116/analsci.26.1081. 101(2):146-52. doi: 10.7547/1010146.