CAS: 1005-38-5; 4-Amino-6-Chloro-2-(Methylthio)Pyrimidine

该化合物是一种环状铁环结构的七环有机化合物,含有氯和甲基硫代替代成分;氯原子在6位置和甲基硫基组在2位置的存在有助于其独特的化学特性,包括潜在的再活性和溶性特性;该化合物一般在室温下是固体,在标准条件下可能具有中等稳定性;由于制药研发活动的潜在生物活动,特别是在合成各种生物活性分子方面,该化合物经常用于制药研究和开发;4位置的地雷功能组增强了其反应性,使其在有机合成中成为有用的中间体;此外,其分子结构允许与生物目标进行各种互动,可以用于治疗用途;在处理和使用安全数据时,应参考任何化学物质,以确保采取适当的预防措施.

结构式图片

相似化合物

478258-67-2 89280-24-0 161611-29-6

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ECHA物质C&L通报REACH预注册

上下游产品

4,6-Dichloro-2-(methylthio)pyrimidine 6-amino-2-methylsulfanylpyrimidin-4(3H)-one ammonia 2-(Methylthio)-4-hydroxy-6-aminopyrimidine N4,N4-dimethyl-2-methylsulfanyl-pyrimidine-4,6-diyldiamineN4,N4-dimethyl-2-methylsulfanyl-pyrimidine-4,6-diyldiamine N4-methyl-2-methylsulfanyl-N4-phenyl-pyrimidine-4,6-diyldiamineN4-methyl-2-methylsulfanyl-N4-phenyl-pyrimidine-4,6-diyldiamine 4-Chlor-cytosin 5-bromo-6-chloro-2-(methylthio)pyrimidine-4-amine

合成工艺路线路线简述

    Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于三氯氧磷体系中,化学反应生成4-氨基-6-氯-2-甲硫基嘧啶
    参考文献:Johnson; Johns,American Chemical Journal,1905,Vol. 34,P. 190
    标题:Johnson; Johns,American Chemical Journal,1905,Vol. 34,P. 190

    专利信息


    专利号:US-2025179012-A1
    优先权日:2022-03-04
    标 题:Synthesis of sulfur(vi) compounds and reagents for same
    发明人:LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY
    权利人:H LEE MOFFITT CANCER CT & RES
    摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.

    专利号:US-6818633-B2
    优先权日:2001-06-29
    标题:Antiviral compounds and methods for synthesis and therapy
    发明人:BALZARINI JAN M R; DE CLERCQ ERIK D A; HOLY ANTONIN
    权利人:ACAD OF SCIENCE CZECH REPUBLIC; REGA STICHTING
    摘要:Novel compounds are provided having formula (I)whereR1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).

    专利号:US-6531470-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-6562844-B2
    优先权日:1998-01-23
    标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-7002020-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-8372971-B2
    优先权日:2004-08-25
    标 题:Heterocyclic compounds and methods of use
    发明人:WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
    权利人:TARGEGEN INC; WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
    摘要:Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.
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    合成参考文献


    摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 464.
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