CAS: 92-35-3; Thiochrome

该化合物是一种化学化合物,其结构特征是维生素B1(三聚胺)的硫诺衍生物,以荧光特性著称,它可用于各种生化应用,特别是在检测和量化硫胺及其衍生物方面.Thiochrome表现出一种黄色至橙色的溶液,可以氧化成硫酸.它的荧光度取决于pH,在特定条件下,排放最优.该化合物在水和有机溶剂中溶解,可提高其在实验室环境中的效用.Thiochrome经常用于分析化学,特别是测量生物样品中硫胺水平的实验.此外,鉴于硫胺在...

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CAS号67-03-8 盐酸硫胺 | CAS号70-16-6 维生素b1 | CAS号13045-13-1 3-氯-4-氧-1-戊醇 | CAS号85196-67-4 2,6a-dimethyl-6... | CAS号874-43-1 5-(氨基甲基)-2-甲基嘧啶... | CAS号1124-01-2 2-疏基-4-甲基-5-羟基乙基噻唑 | CAS号109044-67-9 N-[5-(2-imino-3... | CAS号1153-39-5 3-(4-amino-2-me...

合成工艺路线路线简述

  • 59-43-8 = 92-35-3
    反应条件:1.1 Reagents: Cobalt Oxyhydroxide Solvents: Water; 30 Min,Ph 2,50 °C
    标题:Fluorogenic Interaction Between Cobalt Oxyhydroxide Nanoflakes And Thiamine And Its Application For Glutathione Sensing In Human Whole Blood
    作者:Lai,Yue; Tang,Zeng; Hu,Kelin; Huang,Ke; Zou,Zhirong; Et Al
    参考文献:Microchemical Journal 日期:2023 卷标:191]

    67-03-8 = 92-35-3
    反应条件:1.1 Reagents: Potassium Ferricyanide Solvents: Water; 10 Min,Ph 8,Rt
    标题:Determination Of Total Antioxidant Capacity Using Thiamine As A Natural Fluorescent Probe
    作者:Oliveira,Woodland S.; Santos,Josue C. C.
    参考文献:Journal Of The Brazilian Chemical Society 日期:2020 卷标:31(12) 页码:2479-2490]

    59-43-8 = 92-35-3
    反应条件:1.1 Reagents: Ferrous Sulfate,Hydrogen Peroxide Solvents: Water
    标题:Oxidation Of Thiamine Under The Influence Of Active Oxygen Forms And Hydroperoxides
    作者:Mel'Nichenko,N. G.
    参考文献:Vestsi Natsyyanal'Nai Akademii Navuk Belarusi 日期:2001 卷标:(3) 页码:119-121]

    67-03-8 = 92-35-3 [标题:Reaction Conditions
    标题:Flow-Injection Determination Of Thiamin Based On Its Oxidation To Thiochrome By Mercury(Ii)
    作者:Martinez-Lozano,Carmen; Perez-Ruiz,Tomas; Tomas,Virginia; Abellan,Concepcion
    参考文献:Analyst (Cambridge 日期:1990 卷标:115(2) 页码:217-20]

    59-43-8 = 92-35-3
    反应条件:1.1 Catalysts: Carbon Monoxide
    标题:A New Fluorometric Method For The Determination Of Cyanide
    作者:Goksel,F. Serpil; Aydin,Adnan; Saracoglu,A. Saim
    参考文献:Chimica Acta Turcica 日期:1986 卷标:14(3) 页码:331-52]

    532-40-1 = 92-35-3 + 59-43-8 + 992-46-1
    反应条件:1.1 Reagents: Sodium Hydroxide,Iodine,Potassium Iodide,Oxygen Solvents: Water
    标题:Oxidative Activation Of Thiamine Monophosphate Hydrolysis
    作者:Babii,L. V.; Vovk,A. I.
    参考文献:Fiziologichno Aktivni Rechovini 日期:2002 卷标:(1) 页码:72-77]

    67-03-8 = 92-35-3
    反应条件:1.1 Catalysts: Ammonium Vanadium Oxide ((Nh4)Vo3) Solvents: Water; 5 Min,Ph 1.7 - 2.5,293 - 318 K
    标题:Thermodynamic,Kinetic,Mechanistic And Spectroscopic Investigation Of Thiamine Hydrochloride (Vitamin B1) Oxidation By Vanadium (V),An Insulin Mimetic Compound At Low Ph
    作者:Panda,J.; Das,S. P.; Patnaik,A. K.
    参考文献:European Journal Of Biomedical And Pharmaceutical Sciences 日期:2019 卷标:6(12) 页码:289-297]

    59-43-8 = 92-35-3 [标题:Reaction Conditions
    标题:Electrochemical Derivatization Of Thiamin In A Flow Injection System-Application To Thiamin Analysis
    作者:Kusube,Kenichi; Abe,Kouichi; Hiroshima,Osamu; Ishiguro,Yoshinobu; Ishikawa,Seiji; Et Al
    参考文献:Chemical & Pharmaceutical Bulletin 日期:1983 卷标:31(10) 页码:3589-94]

    70-16-6 = 92-35-3
    反应条件:1.1 Reagents: Phosphorous Acid,Diethyl Ester Solvents: Methanol
    标题:Pyrimidine Derivatives And Related Compounds. Lxv. Reactions Of Thiamine With Carbon Disulfide
    作者:Takamizawa,Akira; Hirai,Kentaro; Ishiba,Teruyuki
    参考文献:Chemical & Pharmaceutical Bulletin 日期:1969 卷标:17(11) 页码:2299-305]

    = 92-35-3 [标题:Reaction Conditions
    标题:Rate Of Oxidation Of Thiamine By Hg(Ii) In Alkaline Medium
    作者:Hina,Rateb H.
    参考文献:Asian Journal Of Chemistry 日期:2000 卷标:12(3) 页码:650-654]

    = 92-35-3 [标题:Reaction Conditions
    标题:Thiamine Oxidative Transformations Catalyzed By Copper Ions And Ascorbic Acid
    作者:Stepuro,I. I.; Piletskaya,T. P.; Stepuro,V. I.; Maskevich,S. A.
    参考文献:Biochemistry (Moscow)(Translation Of Biokhimiya (Moscow)) 日期:1997 卷标:62(12) 页码:1409-1414]

    = 92-35-3 [标题:Reaction Conditions
    标题:Reactions Of Thiamine Free Base With Cyanogen Bromide And Hydrogen Peroxide
    作者:Takamizawa,Akira; Ishiguro,Yoshihiko; Makino,Itsuo; Shiro,Motoo
    参考文献:Bitamin 日期:1983 卷标:57(1) 页码:23-30]

    = 92-35-3 [标题:Reaction Conditions
    标题:Formation Of Thiochrome From α-Hydroxyethylthiamine
    作者:Asakawa,Hiroyuki; Imamiya,Eiko; Hirano,Hiroshi
    参考文献:Takeda Kenkyushoho 日期:1971 卷标:30(4) 页码:705-10]

    = 92-35-3 [标题:Reaction Conditions
    标题:Synthesis And Physicochemical Properties Of Thiochrome Phosphates
    作者:Yamanaka,Wataru
    参考文献:Journal Of Vitaminology 日期:1966 卷标:12(3) 页码:231-9]

    45797-13-5 = 92-35-3 + 299-35-4
    反应条件:1.1 Solvents: Acetonitrile
    标题:Thiamin Ylide: Isolation And Identification
    作者:Sugimoto,Hirohiko; Hirai,Kentaro
    参考文献:Tetrahedron Letters 日期:1985 卷标:26(7) 页码:883-6
📜盐酸硫胺置于sodium Ethanolate,4,4'-二硝基二苯二硫醚体系中,用 乙醇 作为反应溶剂,以0.04 G的收率获得产物硫色素
参考文献:含硫类化合物,其药物组合物及应用
标题:含硫类化合物,其药物组合物及应用
摘要:本发明公开了一种含硫类化合物,其药物组合物及应用.本发明提供了一种物质a在制备aβ40和/或aβ42蛋白抑制剂或药物中的应用;所述的药物为用于治疗和/或由aβ40和/或aβ42蛋白介导的疾病的药物或者用于治疗和/或预防神经退行性疾病或衰老的药物,所述的物质a选自如式a1等所示的化合物或其药学上可接受的盐.本发明的化合物,对aβ40及aβ42蛋白具有非常好的抑制作用,有望治疗和/或预防神经退行性疾病或衰老药物.#imgabs0#

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专利信息


专利号:US-2002142422-A1
优先权日:1999-12-16
标 题 :Moss genes from physcomitrella patens encoding proteins involved in the synthesis of amino acids, vitamins, cofactors, nucleotides and nucleosides
发明人：LERCHL JENS; RENZ ANDREAS; EHRHARDT THOMAS; REINDL ANDREAS; CIRPUS PETRA; BISCHOFF FRIEDRICH; FRANK MARKUS; FREUND ANNETTE; DUWENIG ELKE; SCHMIDT RALF-MICHAEL; RESKI RALF
摘要:Isolated nucleic acid molecules, designated MP protein nucleic acid molecules, which encode novel MP proteins from e.g. Phycomitrella patens are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP protein nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MP proteins, mutated MP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from transformed cells, organisms or plants based on genetic engineering of MP protein genes in these organisms.

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合成参考文献


参考文献:10.1007/bf01952304
摘要:Kikuchi Y, Horimoto M, Koyama T, Koyama Y, Tozawa S. Estimation of pore passage time of red blood cells in normal subjects and patients with renal failure. Cellular and Molecular Life Sciences. 1980 Mar;36(3):325–7. doi: 10.1007/bf01952304.
参考文献:10.1016/j.jpba.2006.02.011
摘要:Alonso A, Almendral MJ, Porras MJ, Curto Y. Flow-injection solvent extraction without phase separation. Fluorimetric determination of thiamine by the thiochrome method. J Pharm Biomed Anal. 2006 Sep 18;42(2):171–7. doi: 10.1016/j.jpba.2006.02.011.
摘要:PRUNER G. [New procedure for fluorometric determination of the vitamin B1 with thiochrome method]. Rend Ist Sup Sanit. 1954;17(2):129–34.
参考文献:10.1124/mol.65.1.257
摘要:Lazareno S, Dolezal V, Popham A, Birdsall NJ. Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity. Mol Pharmacol. 2004 Jan;65(1):257–66. doi: 10.1124/mol.65.1.257.
参考文献:10.1007/s00216-002-1324-9
摘要:Ortega-Barrales P, Ruiz-Medina A, Córdova FM, Molina-Díaz A. A flow-through solid-phase spectroscopic sensing device implemented with FIA solution measurements in the same flow cell: determination of binary mixtures of thiamine with ascorbic acid or acetylsalicylic acid. Analytical and Bioanalytical Chemistry. 2002 Jul;373(4-5):227–32. doi: 10.1007/s00216-002-1324-9.
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