CAS: 91366-65-3; 7-Fluorobenzo[c][1,2,5]Oxadiazole-4-Sulfonamide

该化合物是一种含氟苯氧二氮甲醚衍生物,具有磺酰胺功能组,该化合物主要用作荧光标签试剂,因为它与胺和硫磷具有高度反应性,在HPLC和毛虫电光等分析应用中能够进行敏感检测;氟原子的存在增强了其电子提取特性,提高了稳定性和荧光度;氨基磺酰胺组有利于选择性衍生,使其对生物活性化合物的分析具有价值;该试剂特别适合跟踪检测,在温和条件下提供低背景干扰和极好的衍生效率;适合于药物和生物化学的研究.

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欧盟法规

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上下游产品

7-fluoro-2,1,3-benzoxadiazole-4-sulfonyl chloride 4-fluoro-2,1,3-benzoxadiazole ABD-captopril

合成工艺路线路线简述

    📜4-氟-2,1,3-苯并恶二唑置于氯磺酸,Ammonium Hydroxide体系中,用 氯仿 作为反应溶剂,化学反应 3.0H,反应生成 7-氟苯呋咱-4-硫氨
    参考文献:New Fluorogenic Reagent Having Halogenobenzofurazan Structure For Thiols: 4-(Aminosulfonyl)-7-Fluoro-2,1,3-Benzoxadiazole
    标题:New Fluorogenic Reagent Having Halogenobenzofurazan Structure For Thiols: 4-(Aminosulfonyl)-7-Fluoro-2,1,3-Benzoxadiazole
    摘要:
    DOI:10.1021/ac00277A044

    专利信息


    专利号:US-2009325858-A1
    优先权日:2003-03-21
    标 题:Reduction of Zinc-Induced Neurotoxic Injury By Blockade of Nitric Oxide Synthesis
    发明人:FREDERICKSON CHRISTOPHER J
    权利人:ANDRO DIAGNOSTICS INC
    摘要:The present invention provides methods of inhibiting release of zinc from neurons and of preventing zinc-mediated brain injury. Also provided are methods of improving cerebral blood flow while preventing zinc-mediated brain injury. Inhibitors of or activators of nitric oxide synthases modulate nitric oxide synthesis to reduce nitric oxide-induced release of neurotoxic amounts of zinc, thereby reducing zinc-mediated neuronal injury after brain trauma.

    专利号:US-2004235751-A1
    优先权日:2003-03-21
    标题 :Reduction of zinc-induced neurotoxic injury by blockade of nitric oxide synthesis

    专利号:US-10308936-B2
    优先权日:2014-10-08
    标 题 :miR-96-5p inhibitor and a screening method for the inhibitor
    发明人:NAKAKI TOSHIO; KINOSHITA CHISATO
    权利人:UNIV TEIKYO
    摘要:The present invention provides novel medical means to facilitate glutathione (GSH) synthesis in the brain. These means are miR-96-5p inhibitor increasing GSH expression in the brain and a pharmaceutical composition comprising the miR-96-5p inhibitor and having a preventive and/or therapeutic performance to a disease caused by decrease of GSH amount or depression of GSH activity.

    专利号:WO-2004084827-A2
    优先权日:2003-03-21
    标 题:Reduction of zinc-induced neurotoxic injury by blockade of nitric oxide synthesis

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1002/bmc.683
    摘要:Santa T, Aoyama C, Fukushima T, Imai K, Funatsu T. Suppression of thiol exchange reaction in the determination of reduced-form thiols by high-performance liquid chromatography with fluorescence detection after derivatization with fluorogenic benzofurazan reagent, 7-fluoro-2,1,3-benzoxadiazole-4-sulfonate and 4-aminosulfonyl-7-fluoro-2,1,3-benzoxadiazole. Biomed Chromatogr. 2006 Jun;20(6-7):656–61. doi: 10.1002/bmc.683.
    参考文献:10.1007/s11095-009-0047-4
    摘要:Kitamura Y, Kusuhara H, Sugiyama Y. Basolateral Efflux Mediated by Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3) Facilitates Intestinal Absorption of Folates in Mouse. Pharmaceutical Research. 2010 Feb 11;27(4):665–72. doi: 10.1007/s11095-009-0047-4.
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