CAS: 840-97-1; N-Acetyl-L-Tyrosine Ethyl Ester

该化合物是氨基酸乙基乙基乙酸乙酸乙酸的衍生物,其特点是乙酰基质组和乙酯功能组,该化合物一般是白色至白离白晶粉,可溶于乙醇和甲醇等有机溶剂,但在水中可溶解性较少,以其在生物化学应用中的作用而著称,特别是在聚氨酯合成和作为...

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36546-50-6 537-55-3 19764-32-0

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CAS号64-17-5 乙醇 | CAS号537-55-3 N-乙酰-L-酪氨酸 | CAS号949-67-7 L-酪氨酸乙酯 | CAS号108-24-7 乙酸酐 | CAS号75-36-5 乙酰氯 | CAS号2361-96-8 N-乙酰-L-苯丙氨酸乙酯 | CAS号2440-79-1 乙酰酪氨酸甲酯 | CAS号949-67-7 L-酪氨酸乙酯 | CAS号537-55-3 N-乙酰-L-酪氨酸 | CAS号29701-41-5 (2S)-2-acetamid... | CAS号59-92-7 左旋多巴 | CAS号1948-71-6 N-乙酰基-L-酪氨酰胺 | CAS号2361-96-8 N-乙酰-L-苯丙氨酸乙酯 | CAS号2440-79-1 乙酰酪氨酸甲酯

合成工艺路线路线简述

  • 537-55-3 = 840-97-1
    反应条件:1.1 Catalysts: Chymotrypsin
    标题:Optimization Of The Enzymatic Synthesis Of Amino Acid Esters. Reaction In Polyphasic Medium
    作者:Vidaluc,J. L.; Baboulene,M.; Speziale,V.; Lattes,A.; Monsan,P.
    参考文献:Tetrahedron 日期:1983 卷标:39(2) 页码:269-74]

    537-55-3 = 840-97-1
    反应条件:1.1 Reagents: Thionyl Chloride; -8 °C; 30 Min,-8 °C1.2 -8 °C -> Rt; 2 H,Rt; 2 H,75 °C
    标题:Study On Synthesis Process Of N-Acetyl-L-Tyrosine Ethyl Ester
    作者:Tang,Jun; Lu,Zao-Sheng; Han,Qing; Wang,Da-Wei; Ren,Xiao-Li; Et Al
    参考文献:Henan Gongye Daxue Xuebao 日期:2014 卷标:35(6) 页码:72-75]

    537-55-3 = 840-97-1
    反应条件:1.1 Reagents: Water Catalysts: Proteinase (Porous Glass-Immobilized Alk.-Stable) Solvents: Ethanol,Acetone
    标题:Enzymatic Synthesis Of N-Acetyl-L-Tyrosine Ethyl Ester In Organic Media
    作者:Glowacka,Agnieszka; Antczak,Tadeusz; Kolucka,Katarzyna; Trzmiel,Tadeusz
    参考文献:Zywnosc 日期:2000 卷标:7(3) 页码:96-104]

    537-55-3 = 840-97-1 [标题:Reaction Conditions
    标题:Kinetics Of Amino Acid Esterification Catalyzed By Hydrophobic Derivatives Of α-Chymotrypsin
    作者:Remy,Marie Helene; Bacou,Philippe; Bourdillon,Catherine; Thomas,Daniel
    参考文献:Biochimica Et Biophysica Acta 日期:1987 卷标:911(2) 页码:252-5]

    537-55-3 = 840-97-1
    反应条件:1.1 Catalysts: Chymotrypsin
    标题:Enzymic Synthesis Of Amino Acid Esters In Organic Media
    作者:Tarouis,Dominique; Monsan,Pierre; Durand,Gilbert
    参考文献:Bulletin De La Societe Chimique De France 日期:1980 卷标:76 页码:76-9]

    537-55-3 = 840-97-1
    反应条件:1.1 Solvents: Ethanol,Water; 24 H,30 °C
    标题:Endopeptidases Of Bacillus Subtilis Ibtc-3 And B. Alcalophilus Pb92 In Synthesis Of Precursors Of Biologically Active Peptides
    作者:Glowacka,Agnieszka E.; Szczesna-Antczak,Miroslawa H.; Piotrowicz-Wasiak,Malgorzata; Antczak,Tadeusz Z.
    参考文献:Indian Journal Of Biochemistry & Biophysics 日期:2009 卷标:46(3) 页码:213-220]

    537-55-3 = 840-97-1
    反应条件:1.1 Reagents: Thionyl Chloride Solvents: Ethanol; 1 H,80 °C
    标题:Synthesis And Evaluation Of N-Acetyl-L-Tyrosine Based Compounds As Pparα Selective Activators
    作者:Kumar,Rakesh; Ramachandran,Uma; Raichur,Suryaprakash; Chakrabarti,Ranjan; Jain,Rahul
    参考文献:European Journal Of Medicinal Chemistry 日期:2007 卷标:42(4) 页码:503-510]

    4089-07-0 = 840-97-1
    反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 20 Min,0 °C; 2 H,0 °C
    标题:Visible-Light Mediated Tryptophan Modification In Oligopeptides Employing Acylsilanes
    作者:Reimler,Jannik; Studer,Armido
    参考文献:Chemistry - A European Journal 日期:2021 卷标:27(62) 页码:15392-15395]

    537-55-3 = 840-97-1
    反应条件:1.1 Catalysts: Octanal (Reaction Products With α-Chymotrypsin) Solvents: Tetrahydrofuran
    标题:Chymotrypsins Modified By Neutral Or Charged Amphiphiles As Catalysts For Ester Synthesis In Polar Organic Solvents
    作者:Cabaret,Daniel; Boucier,Sophie; Maillot,Sophie; Wakselman,Michel
    参考文献:Biocatalysis 日期:1992 卷标:6(3) 页码:191-9]

    537-55-3 = 840-97-1
    反应条件:1.1 Catalysts: Chymotrypsin
    标题:Enzymic Reactions In Aqueous-Organic Media. V. Medium Effect On The Esterification Of Aromatic Amino Acids By α-Chymotrypsin
    作者:Kise,H.; Shirato,H.
    参考文献:Enzyme And Microbial Technology 日期:1988 卷标:10(10) 页码:582-5]

    537-55-3 = 840-97-1
    反应条件:1.1 Catalysts: Chymotrypsin Solvents: Ethanol,Water
    标题:Enzymic Reactions In Aqueous-Organic Media. Ii. Effects Of Reaction Conditions And Selectivity In The Esterification Of Aromatic Amino Acids By α-Chymotrypsin In Alcohols
    作者:Kise,Hideo; Shirato,Hitoshi; Noritomi,Hidetaka
    参考文献:Bulletin Of The Chemical Society Of Japan 日期:1987 卷标:60(10) 页码:3613-18]

    537-55-3 = 840-97-1
    反应条件:1.1 Catalysts: Chymotrypsin
    标题:Amino Acid Ester Synthesis By Immobilized α-Chymotrypsin
    作者:Mori,Takao; Nilsson,Kurt; Larsson,Per Olof; Mosbach,Klaus
    参考文献:Biotechnology Letters 日期:1987 卷标:9(7) 页码:455-60]

    537-55-3 = 840-97-1
    反应条件:1.1 Reagents: Phosphate Catalysts: Chymotrypsin Solvents: Ethanol,Water
    标题:Enzymic Reactions In Aqueous-Organic Media. 1. Synthesis Of Aromatic Amino Acid Ethyl Esters By α-Chymotrypsin In Solutions Of High Ethanol Concentrations
    作者:Kise,Hideo; Shirato,Hitoshi
    参考文献:Tetrahedron Letters 日期:1985 卷标:26(49) 页码:6081-4]

    2901-77-1 = 840-97-1 [标题:Reaction Conditions
    标题:Optically Active Amino Acids By Enzymic Synthesis
    参考文献:France
📜N-乙酰-L-酪氨酸置于乙醇,氯仿,对甲苯磺酸体系中,化学反应生成 N-乙酰-L-酪氨酸乙酯
参考文献:Barnes Et Al.,Journal Of The Chemical Society,1953,P. 1448,1463
标题:Barnes Et Al.,Journal Of The Chemical Society,1953,P. 1448,1463

海关参考信息

专利信息


专利号:US-5304631-A
优先权日:1990-01-16
标题:Synthetic helizyme enzymes
发明人：STEWART JOHN M; HAHN KARL W; KLIS WIESLAW A
权利人:UNIV COLORADO FOUNDATION
摘要:The design, and synthesis of peptide-based molecules termed helizymes which possess catalytic activity are described herein The catalytic molecules of the invention comprise a number of amphiphilic helical peptides, which interact via hydrophobic interactions and which are bonded at their carboxyl ends to a multifunctional base. Active site residues functional for catalysis are positioned within or at the N-termini of the helical peptides. The helizyme molecule adopts a conformation in aqueous medium such that a substrate binding pocket is formed and such that functional active site geometry results from the association of the helical peptides Specifically exemplified helizymes possess specificities and at least one catalytic activity of chymotrypsin, trypsin and acetylcholine esterase.

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参考文献:10.1038/ncb3255
摘要:Lin R, Elf S, Shan C, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484–96.
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